Abstract
Mannose-binding lectin (MBL) is an activator of the lectin pathway of the C′ system and hence an important component of the innate immune system. Although reports are conflicting, MBL deficiency has been reported to influence the infection susceptibility in hematology/oncology patients or recipients of allogeneic hematopoietic SCT (HSCT). MBL levels and the occurrence of infections were retrospectively analyzed in 98 pediatric HSCT patients. MBL deficiency in recipients was not corrected by HSCT using a donor with normal MBL production. In addition, low serum MBL concentrations were not associated with increased susceptibility to any type of infections post-HSCT in this cohort of pediatric HSCT recipients.
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References
Bouwman LH, Roep BO, Roos A . Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity. Hum Immunol 2006; 67: 247–256.
Eisen DP, Minchinton RM . Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003; 37: 1496–1505.
Jack DL, Klein NJ, Turner MW . Mannose-binding lectin: targeting the microbial world for complement attack and opsonophagocytosis. Immunol Rev 2001; 180: 86–99.
Neth O, Hann I, Turner MW, Klein NJ . Deficiency of mannose-binding lectin and burden of infection in children with malignancy: a prospective study. Lancet 2001; 358: 614–618.
Peterslund NA, Koch C, Jensenius JC, Thiel S . Association between deficiency of mannose-binding lectin and severe infections after chemotherapy. Lancet 2001; 358: 637–638.
Schlapbach LJ, Aebi C, Otth M, Luethy AR, Leibundgut K, Hirt A et al. Serum levels of mannose-binding lectin and the risk of fever in neutropenia pediatric cancer patients. Pediatr Blood Cancer 2007; 49: 11–16.
Mullighan CG, Heatley S, Doherty K, Szabo F, Grigg A, Hughes TP et al. Mannose-binding lectin gene polymorphisms are associated with major infection following allogeneic hemopoietic stem cell transplantation. Blood 2002; 99: 3524–3529.
Mullighan CG, Heatley SL, Danner S, Dean MM, Doherty K, Hahn U et al. Mannose-binding lectin status is associated with risk of major infection following myeloablative sibling allogeneic hematopoietic stem cell transplantation. Blood 2008; 112: 2120–2128.
Rubnitz JE, Howard SC, Willis J, Pui CH, Pounds S, Hayden RT . Baseline mannose binding lectin levels may not predict infection among children with leukemia. Pediatr Blood Cancer 2008; 50: 866–868.
Kilpatrick DC, McLintock LA, Allan EK, Copland M, Fujita T, Jordanides NE et al. No strong relationship between mannan binding lectin or plasma ficolins and chemotherapy-related infections. Clin Exp Immunol 2003; 134: 279284.
Aittoniemi J, Miettinen A, Laine S, Sinisalo M, Laippala P, Vilpo L et al. Opsonising immunoglobulins and mannan-binding lectin in chronic lymphocytic leukemia. Leuk Lymphoma 1999; 34: 381–385.
Bouwman LH, Roos A, Terpstra OT, de Knijff P, van Hoek B, Verspaget HW et al. Mannose binding lectin gene polymorphisms confer a major risk for severe infections after liver transplantation. Gastroenterology 2005; 129: 408–414.
Kilpatrick DC, Stewart K, Allan EK, McLintock LA, Holyoake TL, Turner ML . Successful haemopoietic stem cell transplantation does not correct mannan-binding lectin deficiency. Bone Marrow Transplant 2005; 35: 179–181.
Berger SP, Roos A, Mallat MJ, Fujita T, de Fijter JW, Daha MR . Association between mannose-binding lectin levels and graft survival in kidney transplantation. Am J Transplant 2005; 5: 1361–1366.
Kilpatrick DC . Mannan-binding lectin and stem cell transplantation. In: Karl B Neumann (ed). Hematopoietic Stem Cell Transplantation Research Advances. Nova Science Publishers Inc.: Hauppauge, New York, 2008, pp 1–6.
Eisen DP, Dean MM, Boermeester MA, Fidler KJ, Gordon AC, Kronborg G et al. Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection. Clin Infect Dis 2008; 15: 510–516.
Roos A, Garred P, Wildenberg ME, Lynch NJ, Munoz JR, Zuiverloon TC et al. Antibody-mediated activation of the classical pathway of complement may compensate for mannose-binding lectin deficiency. Eur J Immunol 2004; 34: 2589–2598.
Berger SP, Roos A, Mallat MJ, Schaapherder AF, Doxiadis II, van Kooten C et al. Low pretransplantation mannose-binding lectin levels predict superior patient and graft survival after simultaneous pancreas-kidney transplantation. J Am Soc Nephrol 2007; 18: 2416–2422.
Thiel S, Frederiksen PD, Jensenius JC . Clinical manifestations of mannan-binding lectin deficiency. Molec Immunol 2006; 43: 86–96.
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We thank Dr T Fujita (Fukushima, Japan) for providing the monoclonal anti-MBL antibody.
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Chaudhry, S., Chaudhry, S., Jansen-Hoogendijk, A. et al. Mannose-binding lectin levels and infections in children after allogeneic hematopoietic SCT. Bone Marrow Transplant 45, 289–293 (2010). https://doi.org/10.1038/bmt.2009.159
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DOI: https://doi.org/10.1038/bmt.2009.159
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