Abstract
Plerixafor, a novel CXCR4 inhibitor, is effective in mobilizing PBSCs particularly when used in conjunction with G-CSF. In four cohorts, this pilot study explored the safety of plerixafor mobilization when incorporated into a conventional stem cell mobilization regimen of chemotherapy and G-CSF. Forty (26 multiple myeloma and 14 non-Hodgkin's lymphoma) patients were treated with plerixafor. Plerixafor was well tolerated and its addition to a chemo-mobilization regimen resulted in an increase in the peripheral blood CD34+ cells. The mean rate of increase in the peripheral blood CD34+ cells was 2.8 cells/μl/h pre- and 13.3 cells/μl/h post-plerixafor administration. Engraftment parameters were acceptable after myeloblative chemotherapy, with the median day for neutrophil and plt engraftment being day 11 (range 8–20 days) and day 13 (range 7–77 days), respectively. The data obtained from the analysis of the cohorts suggest that plerixafor can safely be added to chemotherapy-based mobilization regimens and may accelerate the rate of increase in CD34+ cells on the second day of apheresis. Further studies are warranted to evaluate the effect of plerixafor in combination with chemomobilization on stem cell mobilization and collection on the first and subsequent days of apheresis, and its impact on resource utilization.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hatse S, Balzarini J, Liekens S . Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR4. Biochem Biophys Res Commun 2006; 348: 192–9.
Hendrix C, Collier A, Lederman M, Schols D, Pollard R, Brown S et al. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection. J Acquir Immune Defic Syndr 2004; 37: 1253–1262.
Liles W, Broxmeyer H, Rodger E, Wood B, Hubel K, Cooper S et al. Mobilization of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003; 102: 2728–2730.
Liles W, Rodger E, Broxmeyer H, Dehner C, Badel K, Calandra G et al. Augmented mobilization and collection of CD34+ hematopoietic cells from normal human volunteers stimulated with granulocyte-colony-stimulating factor by single-dose administration of AMD3100, a CXCR4 antagonist. Transfusion 2005; 45: 295–300.
Flomenberg N, Devine S, Dipersio J, Liesveld J, McCarty J, Rowley S et al. The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone. Blood 2005; 106: 1867–1874.
Gazitt Y, Freytes C, Akay C, Badel K, Calandra G . Improved mobilization of peripheral blood CD34(+) cells and dendritic cells by AMD3100 plus granulocyte-colony-stimulating factor in non-hodgkin's lymphoma patients. Stem Cells Dev 2007; 16: 657–666.
DiPersio JF, Micallef INM, Stiff PJ, Bolwell BJ, Maziarz RT, Bridger G et al. Months report from the Phase 3 study of plerixafor+G-CSF vs placebo+G-CSF for mobilization of hematopoietic stem cell for autologous transplant in patients with NHL. Blood (ASH Ann Meet Abstr) 2008; 112: 1136.
DiPersio JF, Stadtmauer EA, Nademanee AP, Micallef INM, Stiff PJ, Bridger G et al. 12 months report from a Phase 3 study of plerixafor+G-CSF vs placebo+G-CSF for mobilization of hematopoietic stem cell for autologous transplant in patients with multiple myeloma. Blood (ASH Ann Meet Abstr) 2008; 112: 3312.
DiPersio J, Stadtmauer EA, Nademanee AP, Stiff P, Micallef I, Angell J et al. A Phase III, multicenter, randomized, double-blind, placebo-controlled, comparative trial of AMD3100 (plerixafor)+G-CSF vs G-CSF+placebo for mobilization in multiple myeloma (MM) patients for autologous hematopoietic stem cell (aHSC) transplantation. Blood (ASH Ann Meet Abstr) 2007; 110: 445.
DiPersio JF, Micallef I, Stiff PJ, Bolwell BJ, Maziarz RT, Angell J et al. A Phase III, multicenter, randomized, double-blind, placebo controlled, comparative trial of AMD3100 (plerixafor)+G-CSF vs placebo+G-CSF in non-Hodgkin's lymphoma (NHL) patients for autologous hematopoietic stem cell (aHSC) transplantation. ASH Ann Meet Abstr 2007; 110: 601.
Demirer T, Buckner C, Bensinger W . Optimization of peripheral blood stem cell mobilization. Stem Cells 1996; 14: 106–116.
Nademanee A, Sniecinski I, Schmidt GM, Dagis AC, O'Donnell MR, Snyder DS et al. High-dose therapy followed by autologous peripheral-blood stem-cell transplantation for patients with Hodgkin's disease and non-Hodgkin's lymphoma using unprimed and granulocyte colony-stimulating factor-mobilized peripheral-blood stem cells. J Clin Oncol 1994; 12: 2176–2186.
Bensinger WI, Rowley SD, Demirer T, Lilleby K, Schiffman K, Clift RA et al. High-dose therapy followed by autologous hematopoietic stem-cell infusion for patients with multiple myeloma. J Clin Oncol 1996; 14: 1447–1456.
Fu S, Liesveld J . Mobilization of hematopoietic stem cells. Blood Rev 2000; 14: 205–218.
Jansen J, Hanks S, Thompson JM, Dugan MJ, Akard LP . Transplantation of hematopoietic stem cells from the peripheral blood. J Cell Mol Med 2005; 9: 37–50.
Jansen J, Thompson JM, Dugan MJ, Nolan P, Wiemann MC, Birhiray R et al. Peripheral blood progenitor cell transplantation. Ther Apher 2002; 6: 5–14.
Akard LP, Thompson JM, Dugan MJ, Wiemann M, Greenspan A, Hanks S et al. Matched-pair analysis of hematopoietic progenitor cell mobilization using G-CSF vs. cyclophosphamide, etoposide, and G-CSF: enhanced CD34+ cell collections are not necessarily cost-effective. Biol Blood Marrow Transplant 1999; 5: 379–385.
Calandra G, McCarty J, McGuirk J, Tricot G, Crocker SA, Badel K et al. AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin's lymphoma, Hodgkin's disease and multiple myeloma patients previously failing mobilization with chemotherapy and/or cytokine treatment: compassionate use data. Bone Marrow Transplant 2008; 41: 331–338.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Dugan, M., Maziarz, R., Bensinger, W. et al. Safety and preliminary efficacy of plerixafor (Mozobil) in combination with chemotherapy and G-CSF: an open-label, multicenter, exploratory trial in patients with multiple myeloma and non-Hodgkin's lymphoma undergoing stem cell mobilization. Bone Marrow Transplant 45, 39–47 (2010). https://doi.org/10.1038/bmt.2009.119
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/bmt.2009.119
Keywords
This article is cited by
-
Stem cell mobilization in multiple myeloma: challenges, strategies, and current developments
Annals of Hematology (2023)
-
The timing of plerixafor addition to G-Csf and chemotherapy affects immunological recovery after autologous stem cell transplant in multiple myeloma
Bone Marrow Transplantation (2020)
-
Optimal chemo-mobilization for the collection of peripheral blood stem cells in patients with multiple myeloma
BMC Cancer (2019)
-
An effective mobilization strategy for lymphoma patients after failed upfront mobilization with plerixafor
Bone Marrow Transplantation (2014)
-
Plerixafor is superior to conventional chemotherapy for first-line stem cell mobilisation, and is effective even in heavily pretreated patients
Blood Cancer Journal (2014)