Review

Bone Marrow Transplantation (2008) 41, 495–503; doi:10.1038/sj.bmt.1705888; published online 22 October 2007

Treatment options for the management of acute leukaemia relapsing following an allogeneic transplant

B E Shaw1,2 and N H Russell3

  1. 1Section of Haemato-Oncology, Royal Marsden Hospital, Surrey, UK
  2. 2Anthony Nolan Research Institute, London, UK
  3. 3Department of Haematology, Nottingham University Hospitals, Nottingham, UK

Correspondence: Dr BE Shaw, Blood and Marrow Transplantation, Institute of Cancer Research/Royal Marsden Hospital, Brookes Lawley Building, 15 Cotswold Road, Belmont, Sutton, Surrey SM2 5NG, UK. E-mail: bshaw@doctors.org.uk

Received 13 June 2007; Revised 20 August 2007; Accepted 13 September 2007; Published online 22 October 2007.

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Abstract

The management of acute leukaemia which relapses following an allogeneic stem cell transplant remains a major challenge. In this review we summarize the outcomes of the currently available treatment modalities and discuss emerging novel approaches.

Keywords:

haematopoietic cell transplantation, acute leukaemia, relapse, GvL, donor leucocyte infusions

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