Original Article
Bone Marrow Transplantation (2008) 41, S96–S99; doi:10.1038/bmt.2008.64
Non Malignant Diseases
Haematopoietic SCT in autoimmune diseases in children: rationale and new perspectives
M Rabusin1, M Andolina1 and N Maximova1 on behalf of the EBMT Paediatric and Autoimmune Diseases Working Parties
Bone Marrow Transplantation Unit, Department of Paediatrics, Institute of Maternal and Child Health Burlo Garofolo, Trieste, Italy
Correspondence: Dr M Rabusin, Bone Marrow Transplantation Unit, Department of Paediatrics, Institute for Maternal and Child Health Burlo Garofolo, Via dell'Istria 65/1, Trieste PO Box 34100, Italy. E-mail: rabusin@burlo.trieste.it
Abstract
The possible role of haematopoietic SCT (HSCT) for the treatment of severe autoimmune diseases was originally supported by animal experiments and remission of concomitant autoimmune diseases in patients undergoing transplantation for haematological disorders. Since 1996, over 100 procedures were performed in children with different severe autoimmune diseases such as juvenile idiopathic arthritis, systemic lupus erythematosus, systemic sclerosis, immune cytopaenias and Crohn's disease. This review tries to summarize the published data on efficacy and toxicity of HSCT in this group of patients.
Keywords:
haematopoietic SCT, autoimmune disease, children
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