TABLE 1
FROM:
Reduced intensity conditioning and allogeneic stem cell transplantation in childhood malignant and nonmalignant diseases
P Satwani, N Cooper, K Rao, P Veys and P Amrolia
BACK TO ARTICLETable 1. Reduced intensity allogeneic stem cell transplant in children and adolescents with malignant disease
| Center/reference | n | Diseases | Conditioning | Donors | >90% Donor chimerism (%) | Graft failure (%) |  Grade II GVHD (%) | Overall survival (%) |
|---|---|---|---|---|---|---|---|---|
| CUMC5 | 13 | AML, CML, NBL, NHL, HD | FLU (150 mg/m2)/BU (6.4–8 mg/kg) or CY (60–120 mg/kg)/ ATG or Campath | MRD UCB | 93 | 7 | 23 | 78 |
| University Hospital, Mexico6 | 15 | AML, CML, ALL | BU (8 mg/kg)/CY (90 mg/kg) | MSD | 66 | NA | 25 | 46 |
| CMHC7 | 10 | ALL | FLU (180 mg/m2)/BU (6.4 mg/kg)/ATGCRT | MUD MSD | 90 | 10 | 20 | 40 |
| CUMC8 | 8 | AML | FLU (180 mg/m2)/BU (6.4–8 mg/kg)ATG | 88 | 12 | 12 | 63 | |
| University of Kiel, Germany9 | 6 | HD | FLU (125–160 mg/m2)/BU (8–12 mg/kg)/ALG | MUD MSD MMRD | 100* | 0 | 50 | 50 |
Abbreviations: AML=acute myeloblastic leukemia; ALG=anti-lymphocyte globulin; ALL=acute lymphoblastic leukemia; ATG=antithymocyte globulin; BU=busulfan; CMHC=Children's Memorial Hospital, Chicago; CML=chronic myeloid leukemia; CRT=cranio spinal radiation; CUMC=Columbia University Medical Center; CY=cyclophosphamide; FLU=fludarabine; HD=Hodgkin's disease; MMRD=mismatched related donor; MRD=matched related donor; MSD=matched sibling donor; MUD=matched unrelated donor; NA=not available; NBL=neuroblastoma; NHL=non-Hodgkin's lymphoma; UCB=umbilical cord blood.
