1. ¹Hematology Department, Eurocord Hôpital, Saint Louis, Paris, France
2. ²Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, MN, USA

Correspondence: Professor E Gluckman, Service de Greffe Moelle, Hopital St Louis, Eurocord, 1 avenue Claude Vellefaux, 75475 Paris cedex 10, France. E-mail: eliane.gluckman@sls.aphp.fr

Received 6 September 2007; Revised 8 November 2007; Accepted 9 November 2007; Published online 17 December 2007.

Abstract

Aplastic anemia is a rare disease in children that is most commonly idiopathic and less often a hereditary disorder. Hereditary bone marrow failure (BMF) syndromes, however, should be considered both in children and in adults before any attempt at treatment. Precise diagnosis is important because it will modify prognostic treatment options and the results of bone marrow transplantation. In this review, we will report recent results of treatment of Fanconi anemia and other hereditary BMF syndromes.