Bone Marrow Transplantation

TABLE 1

FROM:

Outcomes of a second non-myeloablative allogeneic stem cell transplantation following graft rejection

B J Byrne, M Horwitz, G D Long, C Gasparetto, K M Sullivan, J Chute, N J Chao and D A Rizzieri

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Table 1. Patient characteristics and outcomes

Age at first transplant Disease First preparatory regimen Donor HLA match Engrafted Time to second transplant (months) Second preparatory regimen Donor HLA match Engrafted Survival from second transplant Cause of death
20ThalassemiaFCCSib 6/6No25.8SameSib, 6/6Yes, RFLP 23%Alive, 5 yearsN/A
42Nodal marginal zone lymphomaFCCFather 4/6No3.2SameSib, 3/6Yes, RFLP 3%Died 1,1 monthTRM: diffuse alveolar hemorrhage
42Renal cellFCCSon 3/6No2.1SameSameNoDied 3, 2 monthsPD
49AMLFCCSib 4/6No2.3SameDaughter, 4/6Yes, RFLP 96%Alive, 10 monthsN/A
47Mantle cell/MDSFCCSon 4/6No2.3SameSon, 3/6Yes, RFLP 97%Died, 7 monthsPD
50MDS/AMLFCCDaughter 3/6No2.3SameDifferent daughter, 3/6Yes, RFLP 39%Alive, 7 monthsN/A
68Myelofibrosis/AMLOne daySib 6/6Yes, RFLP 63%14FCCSameYes, RFLP 98%Alive, 2.5 yearsN/A
59CMLFCCSib 4/6Yes, RFLP 61%4.2SameSib, 4/6Yes, RFLP 9%Died, 9.5 monthsPD
55Renal cellFCCSib 3/6Yes, RFLP 30%3SameSameYes, RFLP 94%Died, 1 monthPD
33MDS/AMLFCCFather 4/6Yes, RFLP 5%1.7SameSameNo, engrafted with third trans.Died, 7.6 monthsTRM: infections
34AMLOne daySib 3/6Yes, RFLP 44%2.5FCCFather, 3/6Yes, RFLP 98%Alive, 3 yearsN/A

 Abbreviations: FCC=fludarabine 30 mg/m2 on days -5 to -1 (150 mg/m2 total), cyclophosphamide 500 mg/m2 on days -5 to -2 (2000 mg/m2 total) and alemtuzumab 20 mg on days -4 to 0; N/A=not applicable; one day=fludarabine 30 mg/m2, cyclophosphamide 2000 mg/m2, alemtuzumab 20 mg and TBI 200 cGy all delivered on day -1; PD=progressive disease; Sib=sibling; TRM=treatment-related mortality.

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