Six cases of leprosy associated with allogeneic hematopoietic SCT

doi:doi:10.1038/sj.bmt.1705824

Bone Marrow Transplantation (2007) 40, 859–863; doi:10.1038/sj.bmt.1705824; published online 27 August 2007

Post-Transplant Events

Six cases of leprosy associated with allogeneic hematopoietic SCT

F Pieroni¹, A B P L Stracieri¹, D A Moraes¹, E J A Paton², F P Saggioro¹, G M N Barros¹, J C Barros³, M C B Oliveira¹, M A Coutinho¹, N S Castro³, A C Vigoritto⁴, P Trabasso⁴, C A Souza⁴, M P de Souza⁵, M A Mauad⁵, V A R Colturato⁵, B P Simões¹, N P Foss¹ and J C Voltarelli¹

¹University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil
²Cancer Hospital of Barretos—Pio XII Foundation, Barretos, Brazil
³Santa Casa de Misericórdia, School of Medicine, São Paulo, Brazil
⁴University Hospital, School of Medical Sciences, State University of Campinas, São Paulo, Brazil
⁵Cancer Hospital of Jaú—Amaral Carvalho Foundation, São Paulo, Brazil

Correspondence: Dr F Pieroni, Bone Marrow Transplantation Unit, Clinical Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes, No. 3900, Campus Universitário—Monte Alegre, Ribeirão Preto, São Paulo 14048-900, Brazil. E-mail: pieronifabiano@uol.com.br

Received 5 January 2007; Revised 21 June 2007; Accepted 9 July 2007; Published online 27 August 2007.

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Abstract

We report here the first six cases of leprosy associated with HLA-identical allogeneic SCT in different phases and with different findings and outcomes. Skin and peripheral nerves may be sites of leprosy associated with SCT, stressing the importance of differential diagnosis between leprosy and GVHD or drug reactions. Clinical manifestations of leprosy before or after transplantation did not influence the outcome of SCT in our cases.