Review

Bone Marrow Transplantation (2007) 40, 609–619; doi:10.1038/sj.bmt.1705757; published online 2 July 2007

Bone marrow-derived mesenchymal stromal cells for the repair of central nervous system injury

A M Parr1, C H Tator1 and A Keating2

  1. 1Department of Surgery, University Health Network and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
  2. 2Department of Medicine, University Health Network and Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Correspondence: Dr AM Parr, McL12-423, Toronto Western Hospital, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8. E-mail: annmparr@hotmail.com

Received 29 May 2007; Accepted 29 May 2007; Published online 2 July 2007.

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Abstract

Transplantation of bone marrow-derived mesenchymal stromal cells (MSCs) into the injured brain or spinal cord may provide therapeutic benefit. Several models of central nervous system (CNS) injury have been examined, including that of ischemic stroke, traumatic brain injury and traumatic spinal cord injury in rodent, primate and, more recently, human trials. Although it has been suggested that differentiation of MSCs into cells of neural lineage may occur both in vitro and in vivo, this is unlikely to be a major factor in functional recovery after brain or spinal cord injury. Other mechanisms of recovery that may play a role include neuroprotection, creation of a favorable environment for regeneration, expression of growth factors or cytokines, vascular effects or remyelination. These mechanisms are not mutually exclusive, and it is likely that more than one contribute to functional recovery. In light of the uncertainty surrounding the fate and mechanism of action of MSCs transplanted into the CNS, further preclinical studies with appropriate animal models are urgently needed to better inform the design of new clinical trials.

Keywords:

MSC, mesenchymal stem cells, marrow stromal cells, neuronal tissue regeneration, tissue engineering

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