1. ¹Servicio de Hematología, Hospital Universitario 'Dr José Eleuterio González', Universidad Autónoma de Nuevo León, Nuevo León, México
2. ²Centro de Hematología y Medicina Interna de Puebla, Puebla, México

Correspondence: Dr D Gómez-Almaguer, Servicio de Hematología, Hospital Universitario UANL, París 3029 Col.Cumbres CP64610, Monterrey, Nuevo León, México. E-mail: dr_gomez@infosel.net.mx

Received 15 January 2007; Revised 13 March 2007; Accepted 21 March 2007; Published online 28 May 2007.

Abstract

A group of 132 patients with both malignant and nonmalignant conditions was allografted using the 'Mexican' method of non-ablative conditioning. The conditioning was delivered on an outpatient basis and the procedure was planned to be conducted on outpatients in all cases. While 103 patients (78%) were able to complete the procedure totally as outpatients, 29 (22%) were hospitalized because of fever, mucositis or acute graft-versus-host disease. In a multivariate analysis, although differences were not statistically significant, it was found that the patients who were allografted as outpatients had higher levels of hemoglobin (12 versus 11.8 g/dl), higher platelet counts (248 versus 191 10⁹/l), lower white blood cell counts (11.7 versus 12.4 10⁹/l), higher Karnofsky scale scores (100 versus 90%) and lower creatinine levels (0.9 versus 0.93 mg/dl). A total of 86% of the patients with normal values for these variables could be allografted as outpatients, whereas only 67% of those with abnormal values completed the entire procedure as outpatients. It is concluded that allografting can be accomplished totally on an outpatient basis using the 'Mexican' reduced intensity-conditioning regimen.