Bone Marrow Transplantation

FIGURE 2

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N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy

J Tolar, P J Orchard, K J Bjoraker, R S Ziegler, E G Shapiro and L Charnas

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Figure 2.

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Survival after HSCT+NAC is superior to survival after HSCT alone. Survival of eight consecutive ALD patients with severe disease (defined as PIQ <80 and Loes score >14) who received HSCT at this institution is zero at 1 year after HSCT. In contrast, all three ALD patients (with the same degree of severity) who received NAC before and after HSCT are alive between 8 and 11 months after HSCT. A test for the equality of the survival distributions using log-rank statistic was significant (3.91, df=1, P<0.05).

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