FIGURE 1
FROM:
N-acetyl-L-cysteine improves outcome of advanced cerebral adrenoleukodystrophy
J Tolar, P J Orchard, K J Bjoraker, R S Ziegler, E G Shapiro and L Charnas
BACK TO ARTICLEFigure 1.
Brain MRI scans of 10-year-old boy with advanced cerebral ALD before and after hematopoietic stem cell transplantation. Pre-transplant scan (a, b, c and d) demonstrates extensive white matter changes in periventricular, central and subcortical white matter in parietooccipital, anterior temporal and posterior frontal lobes, corpus callosum, thalamus, internal capsules, auditory and visual pathways with MRI severity score 14.5. MRI scan 90 days after transplant (e, f, g and h) shows mild generalized atrophy with loss of previously affected white matter, except in subcortical parietal area, cystic conversion in internal capsules bilaterally (f, arrow), and no extension into previously uninvolved areas.
