Bone Marrow Transplantation

FIGURE 2

FROM:

Biochemical monitoring after haemopoietic stem cell transplant for Hurler syndrome (MPSIH): implications for functional outcome after transplant in metabolic disease

H Church, K Tylee, A Cooper, M Thornley, J Mercer, E Wraith, T Carr, A O'Meara and R F Wynn

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Figure 2.

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A biochemical profile of an MPS patient who has undergone HSCT. The donor here is a normal related donor, and there is full donor cell engraftment. Leucocyte alpha-iduronidase activity shows natural fluctuation within the normal range. Residual GAGs have fallen in the initial 6 month period post-transplant, reaching a plateau that shows a DS/CS ratio consistently <0.5. These data are typical of patients showing full engraftment from normal donors.

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