Original Article

Bone Marrow Transplantation (2006) 38, 101–109. doi:10.1038/sj.bmt.1705406; published online 5 June 2006

Conditioning Regimens

Health-related quality of life in patients receiving reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation

M F Bevans1, S Marden1, N K Leidy2, K Soeken3, G Cusack1, P Rivera1, H Mayberry1, M R Bishop4, R Childs5 and A J Barrett5

  1. 1Department of Nursing, National Institutes of Health, Bethesda, MD, USA
  2. 2Healthcare Analytics Group, United Biosource Corporation, Bethesda, MD, USA
  3. 3University of Maryland, Baltimore, MD, USA
  4. 4National Cancer Institute, Bethesda, MD, USA
  5. 5Stem Cell Allo Transplantation Section, Hematology Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA

Correspondence: Dr MF Bevans, Department of Nursing, National Institutes of Health, 10 Center Drive, Building 10/Rm 12s235b/MSC 1905, Bethesda, MD 20892, USA. E-mail: mbevans@cc.nih.gov

Received 11 November 2005; Revised 6 April 2006; Accepted 2 May 2006; Published online 5 June 2006.

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Abstract

Reduced-intensity conditioning allogeneic HSCT (RIC) has less regimen-related morbidity and mortality than myeloablative allogeneic HSCT (MT) offering allogeneic transplantation to patients otherwise excluded. Whether these advantages improve health-related quality of life (HRQL) is unknown. We examined the HRQL effects of RIC and MT in patients with hematological diseases pre-transplant (baseline), days 0, 30 100, 1 and 2 years following HSCT. HRQL was measured using the Short Form-36 Health Survey and the Functional Assessment of Cancer Therapy – General and BMT. Data were analyzed using mixed linear modeling adjusting for baseline HRQL differences. Patients (RIC=41, MT=35) were predominately male (67%), in remission/stable disease (65%) with an Eastern Cooperative Oncology Group status less than or equal to1 (97%). HRQL progressively improved (P<0.01) in both groups with higher scores at day 100 compared to days 0 and 30; there was no difference between groups during early recovery. At 2 years, all survivors (n=43) reported HRQL similar or better than baseline. Results suggest RIC and MT patients experience a similar pattern of HRQL improvement during early recovery. Two-year survivors report a return to baseline or better in HRQL by day 100, with the exception of physical health in MT patients.

Keywords:

allogeneic transplant, reduced-intensity conditioning, health-related quality of life

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