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Allografting

Outcome of hematopoietic stem cell transplantation in patients with atypical chronic myeloid leukemia

Bone Marrow Transplantation volume 34, pages 1047–1050 (2004)Cite this article

Summary:

Atypical chronic myeloid leukemia (aCML) occurs rarely and is associated with a poor prognosis when treated with conventional chemotherapy. We evaluated the outcome of aCML after allogeneic hematopoietic stem cell transplantation (HSCT). Nine patients were transplanted from HLA-identical siblings (n=4), HLA-compatible unrelated donors (n=4) or twin brother (n=1). Median follow-up was 55 months after transplant (range, 9.1–118.1 months). One patient who was transplanted in advanced disease with bone marrow from his twin brother relapsed 19 months post transplant. This patient was successfully retransplanted from the original donor. All patients remained in complete remission. Analysis of the leukocyte chimerism of peripheral white blood cells and bone marrow buffy coat cells by VNTR-polymerase chain reaction (PCR) and single-nucleotide polymorphism real-time PCR revealed complete chimerism in all patients who had received an allogeneic transplant. One patient suffering from cerebral toxoplasmosis died 9 months post transplant. All other patients were alive at the time of analysis. Our findings suggest that the outcome of allogeneic or syngeneic transplantation in patients with aCML may not be worse than the outcome of transplantation for BCR-ABL-positive CML.

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Acknowledgements

The authors thank Katja Ahrens, Melanie Kroll, and Ines Riepenhoff for their excellent technical performance of the BCR-ABL PCR, the VNTR-PCR and SNP real-time PCR analyses. This work was supported by grants of the Deutsche José Carreras Leukämie-Stiftung e.V. DJCLS-R02/11 and Deutsche Krebshilfe 70-3093-El4.

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Authors and Affiliations

  1. Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, Germany

    M Koldehoff, D W Beelen, R Trenschel, N K Steckel, R Peceny, M Ditschkowski, H Ottinger & A H Elmaagacli

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  1. M Koldehoff
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  2. D W Beelen
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  3. R Trenschel
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Correspondence to A H Elmaagacli.

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Koldehoff, M., Beelen, D., Trenschel, R. et al. Outcome of hematopoietic stem cell transplantation in patients with atypical chronic myeloid leukemia. Bone Marrow Transplant 34, 1047–1050 (2004). https://doi.org/10.1038/sj.bmt.1704686

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