Review
Bone Marrow Transplantation (2004) 33, 675–690. doi:10.1038/sj.bmt.1704405 Published online 23 February 2004
Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results
A I Benito1, M A Diaz1, M González-Vicent1, J Sevilla1 and L Madero1
1Hematology/Oncology Department and Bone Marrow Transplantation Unit, Niño Jesus Children's Hospital, Autonomous University, Madrid, Spain
Correspondence: Dr LM Lopez, Hematology/Oncology Department, Niño Jesus Children's Hospital, Avda. Menéndez Pelayo 65, 28009 Madrid, Spain. E-mail: oncologia@hnjs.insalud.es
Received 7 August 2002; Accepted 28 June 2003; Published online 23 February 2004.
Abstract
Umbilical cord blood (CB) has been rapidly established as an alternative source of stem cells to bone marrow for allogeneic-related and unrelated hematopoietic transplantation. To date, almost 70 000 CB units are available for transplantation and more than 2000 CB transplants (CBT) have been performed, mostly in children, for the treatment of a variety of malignant and nonmalignant conditions. Considerable experience has been rapidly accumulated in this field and many aspects of CBT have been elucidated, while other questions remain unresolved. A concise review of the clinical results achieved after related and unrelated CBT is presented and discussed.
Keywords:
umbilical cord blood, UCB, children, transplantation, hematopoieteic transplant
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