FIGURES AND TABLES
FROM:
Fatal chemotherapy-induced encephalopathy following high-dose therapy for metastatic breast cancer: a case report and review of the literature
N Cossaart, K S SantaCruz, D Preston, P Johnson and B S Skikne
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Figure 1.
(a) Proton-density-weighted MRI scan demonstrates abnormal increased signal intensity within the caudate nuclei, lentiform nuclei and medial thalami. (b) TI-weighted MRI scan after the administration of gadolinium demonstrates areas of contrast enhancement within the basal ganglia and intense enhancement within the habenular region. (c) Repeat proton-density-weighted MRI scan and (d) TI-weighted MRI scan demonstrate dramatic progressive, confluent abnormal signal intensity within the deep gray matter nuclei and relative lack of involvement of the hemispheric white matter. Administration of gadolinium demonstrates extensive enhancement within the deep gray matter nuclei.
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Figure 2.
Retinal findings: cotton wool exudates involving the retinae of both right and left eyes. Retinal hemorrhage noted infero-nasal to the left optic disc.
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Figure 3.
Histologic section of the stereotactic brain biopsy shows perivascular lymphocytes, capillary luminal narrowing and gliosis.
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Figure 4.
A microscopic region of brain showing extensive infiltration with foamy macrophages.
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Figure 5.
Capillary showing endothelial atypia, luminal narrowing and granular perivascular fibrinoid material.
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