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| October (2) 2002, Volume 30, Number 8, Pages 531-534 |
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| Case Report |
| Successful hematopoietic stem cell transplantation for aplastic anemia following living-related liver transplantation |
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| K Umeda, S Adachi, K Watanabe, N Kimura, Y Lin and T Nakahata |
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Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
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Correspondence to: K Umeda, Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan |
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| Abstract |
| A 1-year-old boy received a living-related liver transplantation (LRLT) from his HLA-haploidentical father to treat acute liver failure following non-A, non-B, non-C hepatitis. He subsequently developed pancytopenia and was diagnosed with aplastic anemia (AA). He was platelet transfusion dependent and developed two episodes of life-threatening intracranial hemorrhage despite immuno-suppressive therapy consisting of cyclosporin A, antithymocyte globulin, and anabolic steroids. He received combined hematopoietic stem cell transplantation (hSCT) with cord blood and bone marrow from an HLA-matched sibling. Conditioning consisted of cyclophosphamide (CY) 200 mg/kg and 7 Gy total lymphoid irradiation (TLI). Marrow engraftment was prompt and there was no significant graft-versus-host disease (GVHD). Bone Marrow Transplantation (2002) 30, 531-534. doi:10.1038/sj.bmt.1703689 |
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| Keywords |
| aplastic anemia; liver transplantation; hepatitis; VOD; hematopoietic stem cell transplantation |
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| Received 1 February 2002; accepted 26 June 2002 |
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| October (2) 2002, Volume 30, Number 8, Pages 531-534 |
| Table of contents Previous Abstract Next Full text PDF |
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