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Outcome of 5651 hematopoietic stem cell transplants for hematological malignancies carried out in Europe in 1993: a reliability study of the registry

Bone Marrow Transplantation volume 30, pages 637–643 (2002)Cite this article

Abstract

Outcome results of observational databases are frequently criticized as relying on incomplete information from incomplete patient populations. Few data are available to dispute these arguments of selection bias. The European Group for Blood and Marrow transplantation (EBMT) decided to address this question by evaluating the hematopoietic stem cell transplants performed in 1993. A comprehensive survey was launched in an effort to collect informations on all transplants for hematological malignancies performed throughout Europe during the year 1993. The main goals of this effort were to compare the group of spontaneously reported patients with the group of retrospectively solicited patients, and to give an accurate estimate of the outcome of all patients. For the year 1993, the annual EBMT activity survey indicated 6336 transplants performed for hematological malignancies in Europe. A total of 5651 transplants could be analyzed; 2595 were reported spontaneously by the teams (group A) and 3056 were retrieved on solicitation (group B). Patients and transplant characteristics for group A and B were very similar for most parameters with a few exceptions. There was no statistical difference for outcome at 3 years between groups A and B: disease-free survival (DFS) was 45 ± 1% and 44 ± 1%, relapse incidence (RI) 41 ± 1% and 42 ± 1%, transplant-related mortality (TRM) 23 ± 1% and 23 ± 1%, and overall survival (OS) 54 ± 1% and 55 ± 1%, respectively, for group A and group B. The real outcome at 3 years for the 5651 patients (group A + group B) transplanted in 1993 was 44 ± 1%, 41 ± 1%, 23 ± 1%, and 54 ± 1%, for DFS, RI, TRM and OS, respectively. The outcome at 3 years by transplant modality, autologous or allogeneic transplants, and by disease categories showed no difference between groups A and B.

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Acknowledgements

This work was supported in part by EBMT funds, Association pour la Recherche contre le Cancer (ARC, Villejuif, France), Establissement Français des Greffes (EFG, Paris, France) and Associaton Claude Bernard (Paris, France).

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Authors and Affiliations

  1. Department of Hematology, Hôpital Saint-Antoine, AP-HP, Paris, France and Centre de Recherches Claude Bernard sur la Therapie Cellulaire, Université Pierre et Marie Curie, Paris, France

    L Fouillard & NC Gorin

  2. EBMT Data Management Office (Centre International Greffes AP-HP), Institut des Cordeliers, Paris, France

    L Fouillard, M Labopin, G Bego, V Chesnel & NC Gorin

  3. Division of Hematology, Department of Internal Medecine, Kantonsspital, Basel, Switzerland

    A Gratwohl

  4. Division of Hematology, Leukemia Myeloma Unit, Royal Marsden Hospital, Sutton, UK

    R Powles

  5. Department of Hematology, Ospedale San Martino, Genova, Italy

    A Bacigalupo

Authors
  1. L Fouillard
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  2. M Labopin
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  3. A Gratwohl
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  4. R Powles
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  5. A Bacigalupo
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  6. G Bego
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  7. V Chesnel
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  8. NC Gorin
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on behalf of the European Group for Blood and Marrow Transplantation (EBMT)

Appendix: Teams reporting data for this study

Appendix: Teams reporting data for this study

Dr Abdulkadirov, St Petersburg, Russia; Dr Abecasis, Lisboa, Portugal; Dr Abram, Belfast, Ireland (N); Dr Afanasiev, St Petersburg, Russia; Dr Aglietta, Torino, Italy; Dr Akoglu, Istanbul, Turkey; Dr Albrechtsen, Oslo, Norway; Dr Aldouri, Riyadh, Saudi Arabia; Dr Alessandrino, Pavia, Italy; Dr Amadori, Forli, Italy; Dr Amici, Perugia, Italy; Dr Andreesen, Regensburg, Germany; Dr Arnold, Berlin, Germany; Dr Attal, Toulouse, France; Dr Baccarani, Udine, Italy; Dr Bacigalupo, Genova, Italy; Dr Badell Serra, Barcelona, Spain; Dr Barbui, Bergamo, Italy; Dr Bartsch, Freiburg, Germany; Dr Baruchel, Paris, France; Dr Bauters, Lille Cedex, France; Dr Beguin, Liege, Belgium; Dr Bell, Poole, UK; Dr Ben-Bassat, Tel-Hashomer, Israel; Dr Berdel, Berlin, Germany; Dr Besalduch, Palma de Mallorca, Spain; Dr Biron, Lyon, France; Dr Björkholm, Stockholm, Sweden; Dr Blaise, Marseille, France; Dr Boasson, Angers, France; Dr Boesen, Arhus, Denmark; Dr Boguslawska-Jaworska, Wroclaw, Poland; Dr Boogaerts, Leuven, Belgium; Dr Bordignon, Milano, Italy; Dr Bosi, Firenze, Italy; Dr Broccia, Cagliari, Italy; Dr Brugger, Tübingen, Germany; Dr Büchner, Münster, Germany; Dr Burdach, Düsseldorf, Germany; Dr Burnett, Cardiff, UK; Dr Caballero, Salamanca, Spain; Dr Cacciola, Catania, Italy; Dr Cahn, Besancon, France; Dr Cajozzo, Palermo, Italy; Dr Campilho, Porto, Portugal; Dr Cao, Cagliari, Italy; Dr Carneskog, Goeteborg, Sweden; Dr Carrera Fernández, Oviedo, Spain; Dr Chapuis, Geneva, Switzerland; Dr Clark, Liverpool, UK; Dr Colombat, Tours Cedex, France; Dr Contreras, London, UK; Dr Contu, Cagliari, Italy; Dr Cornelissen, Rotterdam, Netherlands; Dr Cornish, Bristol, UK; Dr Coser, Bolzano, Italy; Dr Coze, Marseille, France; Dr Darbyshire, Birmingham, UK; Dr de Bock, Antwerp, Belgium; Dr De Cataldo, Milano, Italy; Dr De Laurenzi, Rome, Italy; Dr Deb, Rome, Italy; Dr Demeocq, Clermont-Ferrand, France; Dr Dennison, Vellore, India; Dr Devalck, Brussels, Belgium; Dr Diehl, Köln, Germany; Dr Dini, Genova, Italy; Dr Doelken, Greifswald, Germany; Dr Dörken, Berlin, Germany; Dr Efremidis, Athens, Greece; Dr Ehninger, Dresden, Germany; Dr Ernst, Riyadh, Saudi Arabia; Dr Errazquin, Sevilla, Spain; Dr Esquembre, Valencia, Spain; Dr Everaus, Tartu, Estonia; Dr Ezzat, Riyadh, Saudi Arabia; Dr Fassas, Exokhi, Greece; Dr Fasth, Goeteborg, Sweden; Dr Fauser, Idar-Oberstein, Germany; Dr Fekete, Budapest, Hungary; Dr Feremans, Brussels, Belgium; Dr Ferhanoglu, Istanbul, Turkey; Dr Fernández, Madrid, Spain; Dr Fernández-Ranada, Madrid, Spain; Dr Ferrant, Brussels, Belgium; Dr Filip, Hradec Králové, Czech Republic; Dr Finke, Freiburg, Germany; Dr Fischer, Paris, France; Dr Forjaz de Lacerda, Lisboa, Portugal; Dr Franklin, Glasgow, UK; Dr Freund, Rostock, Germany; Dr Friedrich, Ulm, Germany; Dr Fuchsberger, Bratislava, Slovakian Republic; Dr Gadner, Vienna, Austria; Dr Galvin, Wakefield, UK; Dr Garcia Lopez, Barcelona, Spain; Dr Garcia-Conde, Valencia, Spain; Dr Garcia-Larana, Madrid, Spain; Dr Gastearena, Pamplona, Spain; Dr Gastl, Innsbruck, Austria; Dr Gedikoglu, Istanbul, Turkey; Dr Ghavamzadeh, Teheran, Iran; Dr Gianni, Milano, Italy; Dr Gisselbrecht, Paris, France; Dr Gluckman, Paris, France; Dr Gmür, Zurich, Switzerland; Dr Goldman, London, UK; Dr Goldstone, London, UK; Dr Gorin, Paris, France; Dr Gramatzki, Erlangen, Germany; Dr Granena, Barcelona, Spain; Dr Granena, Barcelona, Spain; Dr Graphakos, Athens, Greece; Dr Gratecos, Nice, France; Dr Greco, Giovanni Rotondo, Italy; Dr Green, Woodville, Australia; Dr Greinix, Vienna, Austria; Dr Guéret-Wardle, London, UK; Dr Guilhot, Poitiers, France; Dr Guimaraes, Porto, Portugal; Dr Haas, Heidelberg, Germany; Dr Hamon, Plymouth, UK; Dr Hansen, Herlev, Denmark; Dr Hansz, Poznan, Poland; Dr Harhalakis, Athens, Greece; Dr Harousseau, Nantes, France; Dr Hart, Christchurch, New Zealand; Dr Hartmann, Villejuif, France; Dr Heit, Essen, Germany; Dr Hellmann, Gdansk, Poland; Dr Hermann, Ulm, Germany; Dr Herrmann, Perth, Australia; Dr Hertenstein, Hannover, Germany; Dr Hinterberger, Vienna, Austria; Dr Hoelzer, Frankfurt, Germany; Dr Holmes, Birmingham, UK; Dr Holowiecki, Katowice, Poland; Dr Huber, Mainz, Germany; Dr Hutchinson, Leicester, UK; Dr Iacopino, Reggio Calabria, Italy; Dr Iriondo, Santander, Spain; Dr Izzi, Brescia, Italy; Dr Jacobs, Wynberg, South Africa; Dr Jacobsen, Copenhagen, Denmark; Dr Jaksic, Zagreb, Croatia; Dr Joyner, Exeter, UK; Dr Juliá, Barcelona, Spain; Dr Juliusson, Linköping, Sweden; Dr Karianakis, Athens, Greece; Dr Katz, Montreal, Canada; Dr Kelemen, Budapest, Hungary; Dr Koc, Ankara, Turkey; Dr Kolb, München, Germany; Dr Konigorski, Wezembeek-Oppem, Belgium; Dr Kovacsovics, Lausanne, Switzerland; Dr Koza, Pilsen, Czech Republic; Dr Kubanek, Ulm, Germany; Dr Kvaloy, Oslo, Norway; Dr Labar, Zagreb, Croatia; Dr Lambertenghi Deliliers, Milano, Italy; Dr Lange, Wroclaw, Poland; Dr Lasa Isasti, San Sebastian, Spain; Dr Le Moine, Luxembourg, Luxembourg; Dr Leblond, Paris, France; Dr Legros, Clermont-Ferrand, France; Dr Lehtinen, Tampere, Finland; Dr Lelli, San Giovanni Rotondo, Italy; Dr Leone, Rome, Italy; Dr Leoni, Ancona, Italy; Dr Leyland, Birmingham, UK; Dr Leyvraz, Lausanne, Switzerland; Dr Linkesch, Graz, Austria; Dr Littlewood, Oxford, UK; Dr Ljungman, Huddinge, Sweden; Dr Locatelli, Pavia, Italy; Dr Löfvenberg, Umea, Sweden; Dr Lucarelli, Pesaro, Italy; Dr Lutz, Linz, Austria; Dr M. Michallet, Lyon, France; Dr Macchia, Pisa, Italy; Dr Madero, Madrid, Spain; Dr Madrigal, Hampstead London, UK; Dr Majolino, Palermo, Italy; Dr Maldonado Eloy-Garcia, Malaga, Spain; Dr Malesevic, Belgrade, Serbia; Dr Mandelli, Rome, Italy; Dr Marcus, Cambridge, UK; Dr Marsh, London, UK; Dr Martelli, Perugia, Italy; Dr Martin, Madrid, Spain; Dr Martinez-Rubio, Madrid, Spain; Dr McCann, Dublin, Ireland (Rep.); Dr McVerry, Leeds, UK; Dr Metzner, Oldenburg, Germany; Dr Milanovitch, Minsk, Belarus (Rep.); Dr Milovic, Buenos Aires, Argentinia; Dr Miniero, Torino, Italy; Dr Mistrik, Bratislava, Slovakian Republic; Dr Molina, Grenoble, France; Dr Montserrat, Barcelona, Spain; Dr Moraleda, Murcia, Spain; Dr Morell, Berne, Switzerland; Dr Morris, Belfast, Ireland (N); Dr Mufti, London, UK; Dr Myint, Bournemouth, UK; Dr Newland, London, UK; Dr Niederwieser, Innsbruck, Austria; Dr Niemeyer, Freiburg, Germany; Dr Niethammer, Tübingen, Germany; Dr Nilsson, Lund, Sweden; Dr Noens, Gent, Belgium; Dr Novitzky, Cape Town, South Africa; Dr O'Meara, Dublin, Ireland; Dr Ortega, Barcelona, Spain; Dr Ossenkoppele, Amsterdam, Netherlands; Dr Özerkan, Ankara, Turkey; Dr Papa, Rome, Italy; Dr Parker, Edinburgh, UK; Dr Parry, Gwynedd, UK; Dr Patrone, Genova, Italy; Dr Pavone, Bari, Italy; Dr Pedrazzoli, Pavia, Italy; Dr Pejin, Novi Sad, Yugoslavia; Dr Perona, Verona, Italy; Dr Pession, Bologna, Italy; Dr Pico, Villejuif, France; Dr Pintado Cros, Madrid, Spain; Dr Porcellini, Cremona, Italy; Dr Porta, Brescia, Italy; Dr Powles, Sutton, UK; Dr Pr H Ludwig, Vienna, Austria; Dr Prentice, Hampstead London, UK; Dr Pretnar, Ljubljana, Slovenia; Dr Proctor, Newcastle upon Tyne, UK; Dr Ptushkin, Moscow, Russia; Dr Reid, Harrow, UK; Dr Reiffers, Pessac, France; Dr Remes, Turku, Finland; Dr Richter, Mannheim, Germany; Dr Rio, Paris, France; Dr Rizzoli, Parma, Italy; Dr Robinson, Buenos Aires, Argentinia; Dr Rocha, Pamplona, Spain; Dr Rodeghiero, Vicenza, Italy; Dr Rodrìguez Fernández, Sevilla, Spain; Dr Rohatiner, London, UK; Dr Romeril, Wellington, New Zealand; Dr Rosenmayr, Vienna, Austria; Dr Rosti, Ravenna, Italy; Dr Rowe, Rochester, USA; Dr Russell, Calgary, Canada; Dr Russell, Nottingham, UK; Dr Ruutu, Helsinki, Finland; Dr Saarinen, Helsinki, Finland; Dr Salamon, Vienna, Austria; Dr Samson, London, UK; Dr Sante Tura, Bologna, Italy; Dr Sanz, Valencia, Spain; Dr Sayer, Jena, Germany; Dr Schaefer, Essen, Germany; Dr Schey, London, UK; Dr Schmitz, Kiel, Germany; Dr Schneider, Düsseldorf, Germany; Dr Schots, Brussels, Belgium; Dr Schouten, Maastricht, Netherlands; Dr Schroyens, Antwerp-Edegem, Belgium; Dr Schwarer, Melbourne, Australia; Dr Schwerdtfeger, Wiesbaden, Germany; Dr Seger, Zurich, Switzerland; Dr Selleslag, Brugge, Belgium; Dr Shaw, Sydney, Australia; Dr Siegert, Berlin, Germany; Dr Singer, Bath, UK; Dr Sirchia, Milano, Italy; Dr Slavin, Jerusalem, Israel; Dr Souillet, Lyon, France; Dr Speck, Basel, Switzerland; Dr Spence, Clydebank, UK; Dr Stephan, Saint Etienne, France; Dr Stryckmans, Brussels, Belgium; Dr Sulek, Warszawa, Poland; Dr Sweetenham, Southampton, UK; Dr Tangün, Istanbul, Turkey; Dr Tanyeli, Balcali/Adana, Turkey; Dr Tidefelt, Örebro, Sweden; Dr Tobler, Bern, Switzerland; Dr Torelli, Modena, Italy; Dr Torlontano, Pescara, Italy; Dr Torres Gomez, Cordoba, Spain; Dr Tötterman, Uppsala, Sweden; Dr Touraine, Lyon, France; Dr Treuner, Stuttgart, Germany; Dr Trneny, Praha 2, Czech Republic; Dr Troussard, Caen, France; Dr Trümper, Homburg/Saar, Germany; Dr Uderzo, Monza, Italy; Dr Urban, Graz, Austria; Dr Van den Berg, Amsterdam, Netherlands; Dr Van Marwijk, GK Zwolle, Netherlands; Dr Vandenberghe, Sheffield, UK; Dr Vellenga, Groningen, Netherlands; Dr Verdonck, Utrecht, Netherlands; Dr Vernant, Creteil, France; Dr Veys, London, UK; Dr Vitek, Praha, Czech Republic; Dr Volpe, Avellino, Italy; Dr Vorlìcek, Brno, Czech Republic; Dr Vossen, Leiden, Netherlands; Dr Wachowiak, Poznan, Poland; Dr Walewski, Warszawa, Poland; Dr Wandt, Nürnberg, Germany; Dr Wernli, Aarau, Switzerland; Dr Westerhausen, Duisburg, Germany; Dr Wijermans Hague, Netherlands; Dr Will, Pendlebury, UK; Dr Witte, Nijmegen, Netherlands; Dr Wolf, Marburg, Germany; Dr Yaniv, Petach-Tikva, Israel; Dr Zander, Hamburg, Germany; Dr Zegers, Utrecht, Netherlands; Dr Zintl, Jena, Germany; Dr Zucker, Paris, France.

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Fouillard, L., Labopin, M., Gratwohl, A. et al. Outcome of 5651 hematopoietic stem cell transplants for hematological malignancies carried out in Europe in 1993: a reliability study of the registry. Bone Marrow Transplant 30, 637–643 (2002). https://doi.org/10.1038/sj.bmt.1703712

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