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Immune Reconstitution

Humoral immunity to viral and bacterial antigens in lymphoma patients 4–10 years after high-dose therapy with ABMT. Serological responses to revaccinations according to EBMT guidelines

Bone Marrow Transplantation volume 28, pages 681–687 (2001)Cite this article

Abstract

The aim of this study was to investigate the late effects of ABMT on the immune system with regard to protective humoral immunity against common antigens and responses to recall antigens (vaccines). The vaccines were given according to EBMT guidelines from 1995. The protocol included 35 patients with malignant lymphoma in CR 4–10 years after ABMT, and 35 controls. The results show that prior to ABMT the proportion of patients with protective immunity against poliomyelitis, tetanus and diphtheria was similar to that of controls. At study entry 4–10 years after ABMT, the proportion of patients with protective immunity against poliomyelitis and diphtheria was reduced, while all patients maintained protection against tetanus. A significant decrease in geometric mean antibody concentrations or titres was observed against all three antigens during this period. Serum levels of antibodies against different pneumococcal serotypes were lower in the patients than in the controls prior to vaccination. The responses to pneumococcal vaccination, which is considered to be a T cell-independent vaccine, were studied. Unlike controls, a minority of patients achieved protective levels of antibodies after a single vaccination. Despite persistent levels of protective antibodies in many patients post ABMT, secondary booster responses after one vaccination with T cell-dependent vaccines (tetanus, diphtheria and polio) were absent. In conclusion, this study shows that post ABMT, a full re-vaccination program was necessary to mount responses comparable to those observed after a single vaccination in controls. Bone Marrow Transplantation (2001) 28, 681–687.

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Acknowledgements

The skilful technical assistance of I Bjørnson-Langen and BW Iversen is gratefully acknowledged. We thank Kristian Bartnes and Melissa K Tuck for carefully reviewing the manuscript and Bjørn Straume for valuable statistical consultations.

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Authors and Affiliations

  1. Dept of Oncology, University Hospital of Tromsø, Tromsø, Norway

    T Nordøy & A Kolstad

  2. Dept of Immunology and Transfusion Medicine, University Hospital of Tromsø, Tromsø, Norway

    A Husebekk

  3. Dept of Vaccinology, National Institute of Public Health, Oslo, Norway

    IS Aaberge & AC Kristoffersen

  4. Dept of Bacteriology, National Institute of Public Health, Oslo, Norway

    PA Jenum

  5. Dept of Virology National Institute of Public Health, Oslo, Norway

    HH Samdal & LB Flugsrud

  6. The Norwegian Radium Hospital, Oslo, Norway

    H Holte & S Kvaløy

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Nordøy, T., Husebekk, A., Aaberge, I. et al. Humoral immunity to viral and bacterial antigens in lymphoma patients 4–10 years after high-dose therapy with ABMT. Serological responses to revaccinations according to EBMT guidelines. Bone Marrow Transplant 28, 681–687 (2001). https://doi.org/10.1038/sj.bmt.1703228

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