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| November (2) 2001, Volume 28, Number 10, Pages 981-985 |
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| Technical Report |
| Flexible bronchoscopy in the diagnosis of pulmonary infiltrates following autologous peripheral stem cell transplantation for advanced breast cancer |
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| A O Soubani1, M A Qureshi1 and R D Baynes2 and the Stem Cell Transplantation Section |
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1Division of Pulmonary, Critical Care and Sleep Medicine, Detroit Medical Center and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
2Stem Cell Transplantation Section, Detroit Medical Center and Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA
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Correspondence to: Dr A O Soubani, Harper University Hospital, Division of Pulmonary, Critical Care and Sleep Medicine, 3990 John R- 3 Hudson, Detroit, MI 48201, USA
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Members of the Stem Cell Transplantation Section at Karmanos Cancer Institute: RD Dansey, JL Klein, C Hamm and E Abella |
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| Abstract |
| Flexible bronchoscopy is an important tool in the diagnosis of pulmonary complications following bone marrow transplantation. However, the value of this procedure in autologous peripheral stem cell transplant (APSCT) recipients with pulmonary complications is not well defined. We retrospectively evaluated the diagnostic yield of 27 consecutive bronchoscopies done on 23 APSCT recipients following high-dose chemotherapy for breast cancer. FB resulted in a positive diagnosis in 16 cases (59%). Broncheoalveolar lavage (BAL) was performed on all patients, and transbronchial biopsies (TBB) were carried out in 14. TBB were diagnostic in 10 (71%), with pulmonary drug toxicity as the most common finding (n = 8), followed by metastatic breast cancer (n = 2). BAL was diagnostic in six (22%): bacterial pneumonia (n = 3), aspergillosis (n = 2), Pneumocystis carinii pneumonia (n = 1) and Influenza B (n = 1). The procedure was well tolerated with no major complications except a small pneumothorax in one patient that did not require chest tube insertion. In conclusion, flexible bronchoscopy is a useful tool in the evaluation of pulmonary complications following APSCT for breast cancer. TBB can be done safely with relatively high diagnostic yield. Pulmonary drug toxicity is the most common pathological finding. Bone Marrow Transplantation (2001) 28, 981-985. |
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| Keywords |
| autologous peripheral stem cell transplantation; bone marrow transplantation; pulmonary complications; bronchoscopy; breast cancer |
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| Received 7 May 2001; accepted 6 September 2001 |
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| November (2) 2001, Volume 28, Number 10, Pages 981-985 |
| Table of contents Previous Abstract Next Full text PDF |
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