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Peripheral Blood Stem Cells

Allogeneic haemopoietic cell transplants in Australia, 1996 – A multi-centre retrospective comparison of the use of peripheral blood stem cells with bone marrow

Bone Marrow Transplantation volume 28, pages 21–27 (2001)Cite this article

Abstract

A retrospective comparison was carried out on adult patients receiving HLA-identical allogeneic haemopoietic stem cell transplants from siblings in Australia in 1996, comparing bone marrow with G-CSF-mobilised peripheral blood stem cells. A total of 131 transplant recipients from nine centres were included in this study, of whom 79 received bone marrow, 44 blood stem cells and eight both. All but three of the 131 patients had cyclosporin and methotrexate as graft-versus-host disease prophylaxis. The minimum follow-up time for surviving patients is 27 months. Comparisons were carried out between the BM and PBSC groups. There were no significant differences between groups in age, sex, diagnosis, donor characteristics or pretransplant conditioning. Median time to neutrophil recovery of 0.5 × 109/l was 14 days for PBSC recipients, compared to 19 days for marrow recipients (P < 0.0005). Median time to platelet recovery of 20 × 109/l was 17 days for PBSC recipients, compared to 28 days for marrow recipients (P < 0.0005). There were no significantly increased risks of either acute or chronic GVHD in the PBSC recipients. There were no significant differences between the groups in the incidence of major transplant-related complications, disease-free survival or overall survival. Bone Marrow Transplantation (2001) 28, 21–27.

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Acknowledgements

Our thanks to the clinical and data management staff at the nine centres which took part in this study. Thanks also to Trish Hawkins, Sue Crosby and Pat Bale at ABMTRR and to Dr Kim Cartwright who assisted with comments on the draft. This project was supported in part by a grant from the Arrow Foundation.

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Authors and Affiliations

  1. St Vincent's Hospital, Sydney, NSW, Australia

    I Nivison-Smith & A Dodds

  2. Westmead Hospital, Westmead, NSW, Australia

    KF Bradstock

  3. Royal Melbourne Hospital, Parkville, Victoria, Australia

    J Szer

  4. Royal Brisbane Hospital, Brisbane, Queensland, Australia

    S Durrant

  5. Royal Perth Hospital, Perth, WA, Australia

    R Hermann

  6. The Alfred Hospital, Prahran, Victoria, Australia

    AP Schwarer

  7. Royal Prince Alfred Hospital, Camperdown, NSW, Australia

    J Gibson

  8. Royal Adelaide Hospital, Adelaide, SA, Australia

    LB To

  9. Royal North Shore Hospital, St Leonards, NSW, Australia

    C Arthur

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on behalf of the Australasian Bone Marrow Transplant Cooperative Study Group

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Nivison-Smith, I., Bradstock, K., Szer, J. et al. Allogeneic haemopoietic cell transplants in Australia, 1996 – A multi-centre retrospective comparison of the use of peripheral blood stem cells with bone marrow. Bone Marrow Transplant 28, 21–27 (2001). https://doi.org/10.1038/sj.bmt.1703088

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