Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Review

Using peripheral blood progenitor cells (PBPC) for transplantation in pediatric patients: a state-of-the-art review

Bone Marrow Transplantation volume 26, pages 1291–1298 (2000)Cite this article

Abstract

This paper presents a state-of-the-art review of using mobilized-peripheral blood progenitor cells (PBPC) for transplantation in children. Our own data and those from Medline searches and meeting reports, are analyzed and presented for the different sections that involve transplantation. Recommendations concerning the choice of mobilization regimens, venous access, priming of separator extracorporeal line, anticoagulation, and number of CD34+ cells to infuse for rapid engraftment are proposed. In the allogeneic setting, we analyze ethical and safety aspects of pediatric donor mobilization and collection. Data from the literature suggest that the use of cytokine-mobilized PBPC for allogeneic transplantation appears to be safe both for pediatric donors and patients leading a rapid hematopoietic engraftment with a similar incidence of acute graft-versus-host disease (GVHD). The high incidence of chronic GVHD and its management emerge as the most concerning aspect in allogeneic PBPC transplantation. Bone Marrow Transplantation (2000) 26, 1291–1298.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Lasky L, Bostrom B, Smith J et al. Clinical collection and use of peripheral blood stem cells in pediatric patients Transplant 1989 47: 613–616

    CAS  Google Scholar 

  2. Watanabe T, Takaue Y, Kawano Y et al. Peripheral blood stem cell autotransplantation in treatment of childhood cancer Bone Marrow Transplant 1989 4: 261–265

    CAS  PubMed  Google Scholar 

  3. Takaue Y, Watanabe T, Kawano Y et al. Isolation and storage of peripheral blood hematopoietic stem cells for autotransplantation into children with cancer Blood 1989 74: 1245–1251

    CAS  PubMed  Google Scholar 

  4. Korbling M, Przepiorka D, Huh YO et al. Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts Blood 1995 85: 1659–1665

    CAS  PubMed  Google Scholar 

  5. Bensinger WI, Weaver CH, Appelbaum FR et al. Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor Blood 1995 85: 1655–1658

    CAS  PubMed  Google Scholar 

  6. Schmitz N, Dreger P, Suttorp M et al. Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor) Blood 1995 85: 1666–1672

    CAS  PubMed  Google Scholar 

  7. Körbling M, Chan KW, Anderlini P et al. Allogeneic peripheral blood stem cell transplantation using normal patient-related pediatric donors Bone Marrow Transplant 1996 18: 885–890

    PubMed  Google Scholar 

  8. Li CK, Yuen PM, Chik KW et al. Allogeneic peripheral blood stem cell transplant in children Med Pediatr Oncol 1998 30: 147–151

    CAS  PubMed  Google Scholar 

  9. Villa M, Madero L, Díaz MA et al. Allogeneic peripheral blood progenitor cell (PBPC) transplantation in children Bone Marrow Transplant 1996 18: 231–233

    CAS  PubMed  Google Scholar 

  10. Diaz MA, Alegre A, Villa M et al. Allogeneic peripheral blood progenitor cell (PBPC) transplantation in children with haematological malignancies Br J Haematol 1997 96: 161–164

    CAS  PubMed  Google Scholar 

  11. Takaue Y, Kawano Y, Abe T et al. Collection and transplantation of peripheral blood stem cells in very small children weighting 20 kg or less Blood 1995 86: 372–380

    CAS  PubMed  Google Scholar 

  12. Deméocq F, Kanold J, Chassagne J et al. Successful blood stem cell collection and transplant in children weighing less than 25 kg Bone Marrow Transplant 1994 13: 43–50

    PubMed  Google Scholar 

  13. Diaz MA, Alegre A, Benito A et al. Peripheral blood progenitor cell collection by large-volume leukapheresis in low-weight children J Hematother 1998 7: 63–67

    CAS  PubMed  Google Scholar 

  14. Kanold J, Berger M, Halle P et al. Kinetics of hematopoietic progenitor cell release induced by G-CSF-alone in children with solid tumors and leukemias Bone Marrow Transplant 1998 20: 59–63

    Google Scholar 

  15. Kanold J, Halle P, Rapatel C et al. Safe and efficient PBSC collection in the smallest of children (15 kg) Therapeutic Apher 1998 21: 49–57

    Google Scholar 

  16. Gorlin JB, Humphreys D, Kent P et al. Pediatric large volume peripheral blood progenitor cell collections from patients under 25 kg: a primer J Clin Apheresis 1996 11: 195–203

    CAS  PubMed  Google Scholar 

  17. Shen V, Woodbury C, Killen R et al. Collection and use of peripheral blood stem cells in young children with refractory solid tumors Bone Marrow Transplant 1997 19: 197–204

    CAS  PubMed  Google Scholar 

  18. Urban C, Schwinger W, Benesch M et al. Feasibility of a body weight below 20 kg Med Pediatr Oncol 1997 29: 115–120

    CAS  PubMed  Google Scholar 

  19. Demirer T, Buckner CD, Bensinger WI et al. Peripheral blood stem cell (PBSC) collections after taxol, cyclophosphamide and recombinant human granulocyte colony-stimulating factor (rhG-CSF) J Clin Oncol 1995 13: 1714–1719

    CAS  PubMed  Google Scholar 

  20. Siena S, Bregni M, Bosin L et al. Increase in peripheral blood megakaryocyte progenitors following cancer therapy with high-dose cyclophosphamide and hematopoietic growth factors Exp Hematol 1993 21: 1583–1590

    CAS  PubMed  Google Scholar 

  21. Kanold J, Rapatel C, Berger M et al. Use of G-CSF alone to mobilize peripheral blood stem cells for collection from children Br J Haematol 1994 88: 633–635

    CAS  PubMed  Google Scholar 

  22. Diaz MA, Villa M, Alegre A et al. Collection and transplantation of peripheral blood progenitor cells mobilized by G-CSF alone in children with malignancies Br J Haematol 1996 94: 148–154

    CAS  PubMed  Google Scholar 

  23. Zeller W, Cassens V, Stockshlader M et al. Higher dose of G-CSF increases yield of mobilized CD34+ cells Blood 1994 84: (Suppl. 1) Abstr. 413

    Google Scholar 

  24. Weaver CH, Brich R, Greco FA et al. Mobilization and harvesting of peripheral blood stem cells: a randomized dose escalation trial of filgrastim Br J Haematol 1998 100: 338–347

    CAS  PubMed  Google Scholar 

  25. Halle P, Kanold J, Rapatel C et al. G-CSF 20 μg/kg/day vs 10 μg/kg/day for peripheral blood stem cell mobilization in children can minimize the duration of priming Pediatr Transplant (in press)

  26. Schaison G, Eden OB, Henze G et al. Recommendations on the use of colony-stimulating factors in children: conclusions of a European panel Eur J Pediatr 1998 157: 955–966

    CAS  PubMed  Google Scholar 

  27. Anderlini P, Korbling M, Dale D et al. Allogeneic blood stem cell transplantation: considerations for donors Blood 1997 90: 903–908

    CAS  PubMed  Google Scholar 

  28. To LB, Haylock DN, Simmons PJ, Juttner CA . The biology and clinical uses of blood stem cells Blood 1997 89: 2233–2258

    CAS  PubMed  Google Scholar 

  29. Kawano Y, Takaue Y, Watanabe T et al. Peripheral blood stem cell mobilization with granulocyte colony-stimulating factor and a harvesting procedure in pediatric donors Bone Marrow Transplant 1998 21: (Suppl. 3) S32–S34

    PubMed  Google Scholar 

  30. Kawano Y, Takaue Y, Watanabe T et al. Efficacy of the mobilization of peripheral blood stem cells by granulocyte colony-stimulating factor in pediatric donors Cancer Res 1999 59: 3321–3324

    CAS  PubMed  Google Scholar 

  31. González M, Benito A, Díaz MA et al. Peripheral blood progenitor cell (PBPC) collection by large-volume leukapheresis from pediatric donors Bone Marrow Transplant 1999 23: 631 (letter)

    Google Scholar 

  32. Chan KW, Gajerwski JL, Supkis D et al. Use of minors as bone marrow donors: current attitude and management. A survey of 56 pediatric transplantation centers J Pediatr 1996 128: 644–648

    CAS  PubMed  Google Scholar 

  33. Anderlini P, Przepiorka D, Seong D et al. Clinical toxicity and laboratory effects of granulocyte colony-stimulating factor (filgrastim) mobilization and blood stem cell apheresis from normal donors, and analysis of charges for the procedures Transfusion 1996 36: 590–595

    CAS  PubMed  Google Scholar 

  34. Anderlini P, Przepioska D, Champlin R et al. Biologic and clinical effects of granulocyte colony-stimulating factor in normal individual Blood 1996 88: 2819–2825

    CAS  PubMed  Google Scholar 

  35. Anderlini P, Przepiorka D, Seong D et al. Transient neutropenia in normal donors after G-CSF mobilization and stem cell apheresis Br J Haematol 1996 94: 155–158

    CAS  PubMed  Google Scholar 

  36. De la Rubia J, Martínez C, Solano C et al. Administration of recombinant human granulocyte colony-stimulating factor to normal donors: results of the Spanish National Donor Registry Bone Marrow Transplant 1999 24: 723–728

    CAS  PubMed  Google Scholar 

  37. Murata M, Harada M, Kato S et al. Peripheral blood stem cell mobilization and apheresis: analysis of adverse events in 94 normal donors Bone Marrow Transplant 1999 24: 1065–1071

    CAS  PubMed  Google Scholar 

  38. Cavallaro AM, Lilleby K, Majolino I et al. Three to 6-year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor Bone Marrow Transplant 2000 25: 85–89

    CAS  PubMed  Google Scholar 

  39. Becker PS, Wagle M, Matous S et al. Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor (G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells Biol Blood Marrow Transplant 1997 3: 45–49

    CAS  PubMed  Google Scholar 

  40. Parkkali T, Volin L, Siren MK et al. Acute iritis induced by granulocyte colony-stimulating factor used for mobilization in a volunteer unrelated peripheral blood progenitor cell donor Bone Marrow Transplant 1996 17: 433–434

    CAS  PubMed  Google Scholar 

  41. Norol F, Bonin P, Charpentier F et al. Apparent reactivation of a red cell alloantibody in a healthy individual after G-CSF administration Br J Haematol 1998 103: 256–258

    CAS  PubMed  Google Scholar 

  42. Watanabe T, Kawano Y, Watanabe A et al. Autologous and allogeneic transplantation with peripheral blood CD34+ cells: a pediatric experience Haematologica 1999 84: 167–176

    CAS  PubMed  Google Scholar 

  43. Handgretinger R, Greil J, Schurmann U et al. Positive selection and transplantation of peripheral CD34+ progenitor cells: feasibility and purging efficacy in pediatric patients with neuroblastoma J Hematother 1997 6: 235–242

    CAS  PubMed  Google Scholar 

  44. Díaz MA, Villa M, Madero L et al. Analysis of engraftment kinetics in pediatric patients undergoing autologous PBPC transplantation J Hematother 1998 7: 367–373

    PubMed  Google Scholar 

  45. Haut PR, Cohn S, Morgan E et al. Efficacy of autologous peripheral blood stem cell (PBSC) harvest and engraftment after ablative chemotherapy in pediatric patients Biol Blood Marrow Transplant 1998 4: 38–42

    CAS  PubMed  Google Scholar 

  46. Leibundgut K, Hirt A, Luthy AR et al. Single institution experience with mobilization, harvesting, and reinfusion of peripheral blood stem cells in children with a solid tumor or leukemia Pediatr Hematol Oncol 1994 11: 215–221

    CAS  PubMed  Google Scholar 

  47. Diaz MA, Alegre A, Villa M et al. Pediatric experience with autologous peripheral blood progenitor cell transplantation: influence of CD34+ cell dose in engraftment kinetics Bone Marrow Transplant 1996 18: 699–703

    CAS  PubMed  Google Scholar 

  48. Takaue Y . Peripheral blood stem cell autogarfts for treatment of childhood cancer: a review of the Japanese experience J Hematother 1993 2: 513–518

    CAS  PubMed  Google Scholar 

  49. Kanold J, Halle P, Berger M et al. Large-volume leukapheresis procedure for peripheral progenitor cell collection in children weighting 15 kg or less: efficacy and safety evaluation Med Ped Oncol 1999 32: 7–10

    CAS  Google Scholar 

  50. Madero L, Diaz MA, Benito A et al. Non-tunneled catheters for the collection and transplantation of peripheral blood stem cells in children Bone Marrow Transplant 1997 20: 53–56

    CAS  PubMed  Google Scholar 

  51. Leibundgut K, Muller C, Muller K et al. Tunneled, double lumen Broviac catheters are useful, efficient and safe in children undergoing peripheral blood progenitor cell harvesting and transplantation Bone Marrow Transplant 1996 17: 663–667

    CAS  PubMed  Google Scholar 

  52. Nussbaumer W, Schonitzer D, Trieb T et al. Peripheral stem cell (PBSC) collection in extremely low-weight infants Bone Marrow Transplant 1996 18: 15–17

    CAS  PubMed  Google Scholar 

  53. Brault Ph, Beaussier PS, Bayle C et al. Specificities and optimization of peripheral blood stem cell collection in children: treatment for malignancies can be mobilization Bone Marrow Transplant 1997 20: (Suppl. 1) S5

    Google Scholar 

  54. Leibundgut K, Hirt A, Luthy AR et al. Autotransplants with peripheral blood stem cells and clinical results obtained in children: a review Eur J Pediatr 1993 152: 546–554

    CAS  PubMed  Google Scholar 

  55. Leibundgut K, Muff J, Hirt A et al. Evaluation of Fresenius cell separator AS 104 for harvesting peripheral blood stem cells in pediatric patients Transfus Sci 1994 15: 93–99

    CAS  PubMed  Google Scholar 

  56. Leibundgut K, Hauser SP, Ridolfi-Luthy A et al. Peripheral blood progenitor cell collections in children with low platelet counts are safe Bone Marrow Transplant 1997 20: 345–346

    CAS  PubMed  Google Scholar 

  57. Takaue Y, Watanabe T, Abe T et al. Experience with peripheral blood stem cell collection for autografts in children with active cancer Bone Marrow Transplant 1992 10: 241–248

    CAS  PubMed  Google Scholar 

  58. Marson P, Petris MG, De Silvestro G . Collection of peripheral blood stem cells in pediatric patients: a concise review on technical aspects Bone Marrow Transplant 1998 22: (Suppl. 5) S7–S11

    PubMed  Google Scholar 

  59. Díaz MA, García-Sánchez F, Lillo R et al. Large-volume leukapheresis in pediatric patients: pre-apheresis peripheral blood CD34+ cell count predicts progenitor cell yield Hematologica 1999 84: 30–33

    Google Scholar 

  60. Alegre A, Diaz MA, Madero L et al. Large-volume leukapheresis for peripheral blood stem cell collection in children: a simplified single-apheresis approach Bone Marrow Transplant 1996 17: 923–927

    CAS  PubMed  Google Scholar 

  61. Berenson RJ, Bensinger WI, Hill RS et al. Engraftment after infusion of CD34+ marrow cells in patient with breast cancer or neuroblastoma Blood 1991 77: 1717–1722

    CAS  PubMed  Google Scholar 

  62. Civin CI, Strauss LC, Brovall C et al. Antigenic analysis of hematopoiesis. III: A hematopoietic progenitor cell surface antigen defined by monoclonal antibodies against KG1 cells J Immunol 1984 133: 157–165

    CAS  PubMed  Google Scholar 

  63. Hermouet S, Niaussat AE, Briec A et al. Analysis of platelet recovery after autologous transplantation with G-CSF mobilized CD34+ cells purified from leukapheresis products Hematol Cell Ther 1997 39: 317–325

    CAS  PubMed  Google Scholar 

  64. Ketterer N, Salles G, Raba M et al. High CD34(+) cell counts decrease hematologic toxicity of autologous peripheral blood progenitor cell transplantation Blood 1998 91: 3148–3155

    CAS  PubMed  Google Scholar 

  65. Schiller G, Vescio R, Freytes C et al. Autologous CD34-selected blood progenitor cell transplants for patients with advanced multiple myeloma Bone Marrow Transplant 1998 21: 141–145

    CAS  PubMed  Google Scholar 

  66. Shpall EJ, LeMaistre CF, Holland K et al. A prospective randomized trial of buffy coat versus CD34-selected autologous bone marrow support in high-risk breast cancer patients receiving high-dose chemotherapy Blood 1997 90: 4313–4320

    CAS  PubMed  Google Scholar 

  67. Berger M, Kanold J, Rapatel C et al. Feasibility of a PB CD34+ cell transplantation procedure using standard leukapheresis products in very small children Bone Marrow Transplant 1997 20: 191–198

    CAS  PubMed  Google Scholar 

  68. Kanold J, Berger M, Rapatel C et al. CD34+ cell immunoselection from G-CSF-alone primed peripheral blood in children with low body mass Br J Haematol 1995 91: 431–433

    CAS  PubMed  Google Scholar 

  69. Kawano Y, Takaue Y, Law P et al. Clinically applicable bulk isolation of blood CD34+ cells for autografting in children Bone Marrow Transplant 1998 22: 1011–1017

    CAS  PubMed  Google Scholar 

  70. Lemoli RM, Fortuna A, Raspadori D et al. Selection and transplantation of autologous hematopoietic CD34+ cells for patients with multiple myeloma Leuk Lymphoma 1997 26: (Suppl. 1) 1–11

    PubMed  Google Scholar 

  71. Brenner MK, Rill DR, Moen RC et al. Gene-marking to trace origin of relapse after autologous bone marrow transplantation Lancet 1993 341: 85–89

    CAS  PubMed  Google Scholar 

  72. Rill DR, Santana VM, Roberts WM et al. Direct demonstration that autologous bone marrow transplantation for solid tumors can return a multiplicity of tumorigenic cells Blood 1994 84: 380–384

    CAS  PubMed  Google Scholar 

  73. Tchirkov A, Kanold J, Giollant M et al. Molecular monitoring of tumor cell contamination in leukapheresis products from stage IV neuroblastoma patients before and after positive CD34 selection Med Ped Oncol 1998 30: 228–232

    CAS  Google Scholar 

  74. Tchirkov A, Kanold J, Combaret V et al. Immunological and molecular detection of tumor contamination in leukapheresis products from children with disseminated neuroblastoma: implication for evaluation of tumor cell depletion after CD34 selection Bone Marrow Transplant 1999 24: 229–230

    CAS  PubMed  Google Scholar 

  75. Watanabe T, Kajiume T, Abe T et al. Allogeneic peripheral blood stem cell transplantation in children with hematological malignancies from HLA-matched siblings Med Pediatr Oncol 2000 34: 171–176

    CAS  PubMed  Google Scholar 

  76. Miniero R, Busca A, Pession A et al. Allogeneic peripheral blood stem cell transplantation in children with hematologic malignancies Haematologica 1999 84: 657–660

    CAS  PubMed  Google Scholar 

  77. Kanold J, Yakouben K, Tchirkov A et al. Long term results of CD34+ transplantation in children with neuroblastoma Med Ped Oncol 2000 35: 1–7

    CAS  Google Scholar 

  78. Hartmann O, Le Corroller AG, Blaise D et al. Peripheral blood stem cell and bone marrow transplantation for solid tumors and lymphomas: hematologic recovery and costs. A randomized, controlled trial Ann Intern Med 1997 126: 600–607

    CAS  PubMed  Google Scholar 

  79. Hartmann O, Valteau-Couanet D, Vassal G et al. Prognostic factors in metastatic neuroblastoma in patients over 1 year of age treated with high-dose chemotherapy and stem cell transplantation: a multivariate analysis in 218 patients treated in a single institution Bone Marrow Transplant 1999 23: 789–795

    CAS  PubMed  Google Scholar 

  80. Weaver CH, Hazelton B, Birch R et al. An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative therapy Blood 1995 86: 3961–3969

    CAS  PubMed  Google Scholar 

  81. Bensinger WI, Appelbaum FR, Rowley S et al. Factors that influence collection and engraftment of autologous peripheral blood stem cells J Clin Oncol 1995 13: 2547–2555

    CAS  PubMed  Google Scholar 

  82. Bensinger WI, Longin K, Appelbaum FR et al. Peripheral blood stem cells (PBSCs) collected after recombinant human granulocyte colony-stimulating factor (rhG-CSF): an analysis of factors correlating with the tempo of engraftment after transplantation Br J Haematol 1994 87: 825–831

    CAS  PubMed  Google Scholar 

  83. Dercksen MW, Rodenhuis S, Dirkson MK et al. Subsets of CD34+ cells and rapid hematopoietic recovery after peripheral blood stem-cell transplantation J Clin Oncol 1995 13: 1922–1932

    CAS  PubMed  Google Scholar 

  84. Gonzalez-Requejo A, Madero L, Diaz MA et al. Progenitor cell subsets and engraftment kinetics in children undergoing autologous peripheral blood stem cell transplantation Br J Haematol 1998 101: 104–110

    CAS  PubMed  Google Scholar 

  85. Leibundgut K, von Rohr A, Brülhart K et al. The number of circulating CD34+ blood cells predicts the colony-forming capacity of leukapheresis products in children Bone Marrow Transplant 1995 15: 25–31

    CAS  PubMed  Google Scholar 

  86. Diaz MA, Vicent MG, Garcia-Sanchez F et al. Long-term hematopoietic engraftment after autologous peripheral blood progenitor cell transplantation in pediatric patients: effects of the CD34+ cell dose Vox Sang (in press)

  87. Kessinger A, Smith DM, Strandjord SE et al. Allogeneic transplantation of blood-derived, T-cell depleted hematopoietic stem cells after myeloablative treatment in a patient with acute lymphoblastic leukemia Bone Marrow Transplant 1989 4: 643–646

    CAS  PubMed  Google Scholar 

  88. Russell NH, Hunter A, Rogers S et al. Peripheral blood stem cells as an alternative to marrow for allogeneic transplantation Lancet 1993 341: 1482 (letter)

    Google Scholar 

  89. Anderlini P, Lauppe J, Przepiorka D et al. Peripheral blood stem cell pheresis in normal donors: feasibility and yield of second collections Br J Haematol 1997 96: 415–417

    CAS  PubMed  Google Scholar 

  90. Anderlini P, Przepiorka D, Korbling M et al. Blood stem cell procurement: donor safety issues Bone Marrow Transplant 1998 21: (Suppl. 3) S35–S39

    PubMed  Google Scholar 

  91. Azevedo WM, Aranha FJP, Gouvea JV et al. Allogeneic transplantation with blood stem cells mobilized by rhG-CSF for hematological malignancies Bone Marrow Transplant 1995 16: 647–653

    CAS  PubMed  Google Scholar 

  92. Urbano-Ispizua A, Solano C, Brunet S et al. Allogeneic peripheral blood progenitor cell transplantation: analysis of short-term engraftment and acute GVHD incidence in 33 cases Bone Marrow Transplant 1996 18: 35–40

    CAS  PubMed  Google Scholar 

  93. Russell JA, Brown C, Bowen T et al. Allogeneic blood cell transplantation for hematological malignancy: preliminary comparison of outcomes with bone marrow transplantation Bone Marrow Transplant 1996 17: 703–708

    CAS  PubMed  Google Scholar 

  94. Miflin G, Russell NH, Hutchinson RM et al. Allogeneic peripheral blood stem cell transplantation for haematological malignancies – an analysis of kinetics of engraftment and GVHD risk Bone Marrow Transplant 1997 19: 9–13

    CAS  PubMed  Google Scholar 

  95. Majolino I, Saglio G, Scime R et al. High incidence of chronic GVHD after primary allogeneic peripheral blood stem cell transplantation in patients with hematologic malignancies Bone Marrow Transplant 1996 17: 555–560

    CAS  PubMed  Google Scholar 

  96. Verdeguer A, Bermudez M, de la Rubia J et al. Allogeneic transplantation in children Cytotherapy 1999 1: 195–201

    CAS  PubMed  Google Scholar 

  97. Miniero R, Busca A, Bonetti F et al. Allogeneic transplantation of peripheral blood progenitor cells in children: experience of two pediatric centers Bone Marrow Transplant 1998 22: (Suppl. 5) S33–S36

    PubMed  Google Scholar 

  98. Levine JE, Wiley J, Kletzel M et al. Cytokine-mobilized allogeneic peripheral blood stem cell transplants in children result in rapid and a high incidence of chronic GVHD Bone Marrow Transplant 2000 25: 13–18

    CAS  PubMed  Google Scholar 

  99. Storek J, Gooley T, Siadak M et al. Allogeneic peripheral blood stem cell transplantation may be associated with a high risk of chronic graft-versus-host disease Blood 1997 90: 4705–4709

    CAS  PubMed  Google Scholar 

  100. Urbano-Ispizua A, Garcia Conde J, Brunet S et al. High incidence of chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell transplantation. The Spanish Group of allo-PBPCT Hematologica 1997 82: 683–689

    CAS  Google Scholar 

  101. Horowitz MM, Gale RP, Sondel PM et al. Graft-versus-leukemia reactions after bone marrow transplantation Blood 1990 75: 555–562

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Oncology, ‘Niño Jesús’ Children's Hospital, Madrid, Spain

    MA Díaz, MG Vicent & L Madero

  2. Department of Pediatrics, Unite Bioclinique de Therapie Cellulaire, Centre Hospitalier Universitaire, Clermont-Ferrand, France

    J Kanold, P Halle & F Deméocq

Authors
  1. MA Díaz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Kanold
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. MG Vicent
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Halle
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L Madero
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Deméocq
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Díaz, M., Kanold, J., Vicent, M. et al. Using peripheral blood progenitor cells (PBPC) for transplantation in pediatric patients: a state-of-the-art review. Bone Marrow Transplant 26, 1291–1298 (2000). https://doi.org/10.1038/sj.bmt.1702725

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1702725

Keywords

This article is cited by

Search

Advanced search

Quick links