Abstract
A 23-year-old woman underwent HLA-matched unrelated BMT for CML. She developed cerebral blindness on day 81. Brain magnetic resonance imaging revealed hyperintensity on a T2-weighted image in the white and gray matter of the right frontal and both occipital lobes. Single-photon emission computed tomography (SPECT) was consistent with a decrease in radionuclide uptake in these areas, suggesting a vasoconstrictive mechanism. A diagnosis of CsA-induced encephalopathy was made and CsA was discontinued. Her vision recovered completely after 24 h and abnormal imaging resolved within 2 weeks. This case demonstrates late onset CsA-induced cerebral blindness with the previously unreported abnormalities on SPECT. Bone Marrow Transplantation (2000) 26, 105–108.
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Acknowledgements
We would like to thank Drs M Funauchi and T Azuma for advice in manuscript preparation. This work was supported in part by the Grant-in-Aid for Cancer Research 10-1 from the Ministry of Health and Welfare.
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Uoshima, N., Karasuno, T., Yagi, T. et al. Late onset cyclosporine-induced cerebral blindness with abnormal SPECT imagings in a patient undergoing unrelated bone marrow transplantation. Bone Marrow Transplant 26, 105–108 (2000). https://doi.org/10.1038/sj.bmt.1702467
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DOI: https://doi.org/10.1038/sj.bmt.1702467
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