Bone Marrow Transplantation
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February 2000, Volume 25, Number 4, Pages 427-433
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Immune Recovery
Hematopoietic reconstitution after lethal irradiation and bone marrow transplantation: effects of different hematopoietic cytokines on the recovery of thymus, spleen and blood cells
D Frasca1, F Guidi1, M Arbitrio1, C Pioli1, F Poccia2, R Cicconi2 and G Doria2

1Laboratory of Immunology, AMB-PRO-TOSS, ENEA CR Casaccia, Rome, Italy

2Department of Biology, University of Rome 'Tor Vergata', Rome, Italy

Correspondence to: Dr D Frasca, Laboratory of Immunology, AMB-PRO-TOSS, ENEA CR Casaccia, Via Anguillarese, 301, 00060 S Maria di Galeria, Rome, Italy

Abstract

Lethally irradiated mice were grafted with syngeneic bone marrow cells or left ungrafted. Mice of each group were injected with different hematopoietic cytokines for 5 consecutive days starting immediately after irradiation or left uninjected. The recovery of lymphoid tissues induced by hematopoietic cytokines 7 days after irradiation and bone marrow cell transplantation was comparable to that observed at days 21-28 in irradiated, bone marrow-grafted, but cytokine-uninjected mice. IL-11 or IL-6, in combination with IL-3, was able to hasten thymus, spleen and blood cell numbers and functions. SCF also displayed a detectable effect when used with IL-3. Conversely, the IL-6 super-agonist K-7/D-6 was able, when injected alone, to induce significant recovery of thymus, spleen and blood cells. Thus, K-7/D-6 appears to be a most efficient cytokine for fast reconstitution of lymphoid tissues after irradiation and bone marrow transplantation. Bone Marrow Transplantation (2000) 25, 427-433.

Keywords

hematopoietic cytokines; lymphocytes; X-rays

Received 23 August 1999; accepted 14 October 1999
February 2000, Volume 25, Number 4, Pages 427-433
Table of contents    Previous  Abstract  Next   Full text  PDF