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| February 2000, Volume 25, Number 4, Pages 351-356 |
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| Perspective |
| Stem cell transplantation for treatment of severe autoimmune diseases: current status and future perspectives |
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| E Jantunen and R Myllykangas-Luosujärvi |
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Department of Medicine, Kuopio University Hospital, Kuopio, Finland
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Correspondence to: Dr E Jantunen, Department of Medicine, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland
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| Abstract |
| Autoimmune diseases include a heterogenous group of disorders with variable presentation and severity. Immunosuppressive and immunomodulatory therapies are often used for treatment with considerable success in some cases. These diseases may also be severe and refractory to conventional treatment. Thus more aggressive intervention might be indicated in a subset of patients. Animal studies suggest that high-dose therapy supported by stem cell transplantation may lead to remissions in experimental autoimmune disease models. Anecdotal case reports suggest that the same may be the case in some human autoimmune diseases as well. This review attempts to summarise some current concepts and future perspectives on stem cell transplantation in the treatment of severe autoimmune diseases. Bone Marrow Transplantation (2000) 25, 351-356. |
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| Keywords |
| stem cell transplantation; autoimmune diseases |
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| Received 8 July 1999; accepted 14 October 1999 |
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| February 2000, Volume 25, Number 4, Pages 351-356 |
| Table of contents Previous Abstract Next Full text PDF |
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