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| Progenitor cell mobilisation |
| Granulocyte colony-stimulating factor (G-CSF) dose-dependent efficacy in peripheral blood stem cell mobilization in patients who had failed initial mobilization with chemotherapy and G-CSF |
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| A K W Lie1, C H Hui1,a, T Rawling1, P G Dyson1, D Thorp1, J Benic1, C M Rawling1, I Toogood2, N Horvath1, P J Simmons1 and L B To1 |
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1Division of Hematology, Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, Australia
2Department of Hematology/Oncology, Women's and Children's Hospital, North Adelaide, Australia
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aCorrespondence: Dr C-H Hui, Division of Hematology, Hanson Center for Cancer Research, Institute of Medical and Veterinary Science, Frome Road, Adelaide, SA 5000, Australia |
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| Abstract |
| For 10 consecutive patients in our unit who did not show a significant rise in blood progenitor cells within 14 days following chemotherapy and G-CSF, we increased the G-CSF dose from 5 to 10  g/kg/day (n = 9) or from 10 to 15 g/kg/day (n = 1). As a result, there were significant increases in total yield as well as yield per apheresis of mononuclear cells, CD34+ cells and CFU-GM (P < 0.025, <0.01 and <0.005, respectively). after g-csf dose escalation, six of the 10 patients had sufficient cd34+ cells for performing transplantation. These results demonstrate a dose-dependent response of progenitor cell mobilization by G-CSF when used in combination with chemotherapy. Moreover, increasing the dose of G-CSF as late as the third week of mobilization may still provide sufficient cell yield even with patients who did not show a significant mobilization with conventional doses of G-CSF. |
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| Keywords |
| stem cell mobilization; chemotherapy; G-CSF; CD34; CFU-GM |
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| Received 15 May 1998; accepted 30 June 1998 |
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| November 1998, Volume 22, Number 9, Pages 853-857 |
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