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| Case report |
| HBeAg-negative hepatitis B in a previously thalassemic patient during immunosuppressive therapy for chronic GVHD |
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| S Kostaridou1,a, V Ladis1, A Kattamis1, A Laras2 and S J Hadziyannis2 |
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1First Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Greece
2Academic Department of Medicine, Hippokration General Hospital, Athens, Greece
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aCorrespondence: S Kostaridou, First Department of Pediatrics, Aghia Sophia Children's Hospital, Thivon and M Asias, 115 27 Athens, Greece |
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| Abstract |
| We report the case of a 15-year-old previously thalassemic girl who, 15 months after allogeneic BMT, developed HBeAg-negative hepatitis B (variant with mu-1896). In the absence of another route of transmission, HBV reactivation is postulated. The time of emergence of the HBV variant (with mu-1896) is probably related to the development of anti-HBe immunity. This mutant strain is associated with fulminant hepatitis. The patient achieved complete remission and HBV eradication despite having moderate GVHD and receiving immunosuppressive therapy. |
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| Keywords |
| bone marrow transplantation; HBV mutant; HBV reactivation |
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| Received 19 January 1998; accepted 20 June 1998 |
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| November 1998, Volume 22, Number 9, Pages 919-921 |
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