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| January 1998, Volume 21, Number 2, Pages 209-214 |
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| Case report |
| Granulocyte-macrophage colony-stimulating factor-associated histiocytosis and capillary-leak syndrome following autologous bone marrow transplantation: two case reports and a review of the literature |
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| A Al-Homaidhi, H M Prince, H Al-Zahrani, D Doucette and A Keating |
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University of Toronto Autologous Blood and Marrow Transplant Program, The Toronto Hospital, Toronto, Ontario, Canada
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| Abstract |
| Bone marrow (BM) histiocystosis in association with the administration of granulocyte-macrophage colony- stimulating factor (GM-CSF) is a rare phenomenon with few published cases. We report two cases of BM histiocystosis in patients with Hodgkin's disease treated with GM-CSF after autologous bone marrow transplantation. Both patients also developed clinical features of capillary leak syndrome, another rare complication of GM-CSF administration. GM-CSF-induced histiocystosis should now be considered in the differential diagnosis of delayed engraftment post-autotransplant. |
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| Keywords |
| GM-CSF; histiocytosis; capillary leak syndrome; transplantation |
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| Received 10 July 1997; accepted 28 July 1997 |
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| January 1998, Volume 21, Number 2, Pages 209-214 |
| Table of contents Previous Abstract Next Article PDF |
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