|
|
|
| May 1997, Volume 19, Number 10, Pages 1049-1051 |
| Table of contents Previous Abstract Next Article PDF |
 |
| Case report |
| Reversible brain MRI changes in acyclovir neurotoxicity |
|
| M E G Blohm1, W Nürnberger1, A Aulich2, V Engelbrecht2 and S Burdach1 |
|
1Department of Paediatric Haematology and Oncology, Heinrich Heine University Medical Centre, Düsseldorf, Germany,
2Department of Diagnostic Radiology, Heinrich Heine University Medical Centre, Düsseldorf, Germany
|
|
| Abstract |
| This case report shows reversible brain MRI changes probably associated with acyclovir toxicity. So far, neuroimaging in acyclovir toxicity had been negative or uninformative. A 12-year-old girl developed focal secondary generalizing epileptic fits following 4 weeks of prophylactic administration of acyclovir (3 ´ 10 mg/kg body weight/day i.v.) on day +22 after allogeneic peripheral blood stem cell transplantation for CML. Infective causes were excluded. Brain MRI demonstrated multiple gadolinium-enhancing areas with impairment of the blood-brain barrier in cortical and subcortical regions. Clinical symptoms and neuroimaging pathology resolved completely within 9 days of acyclovir withdrawal. |
|
| Keywords |
| brain; gadolinium contrast; MRI; acyclovir; toxicity |
|
|
|
|
| Received 11 November 1996; accepted 3 February 1997 |
|
| May 1997, Volume 19, Number 10, Pages 1049-1051 |
| Table of contents Previous Abstract Next Article PDF |
|
|
