TABLE OF CONTENTS
Guide to Receptors and Channels (GRAC)
The great proliferation of drug targets in recent years has driven the need to organise and condense the information in a logical way. This is the underlying reason for this Guide to Receptors and Channels (GRAC), distributed with the British Journal of Pharmacology. Our intent is to produce an authoritative but user-friendly publication, which allows a rapid overview of the key properties of a wide range of established or potential pharmacological targets. The aim is to provide information succinctly so that a newcomer to a particular target group can identify the main elements "at a glance".
Targets have been selected for inclusion where there is sufficient pharmacological information to allow clear definition or where, in our view, there is clear interest in this molecular class from the pharmacological community. The underlying philosophy has been to present data on human receptors and to describe agents that represent the most selective available (either by donation or from commercial sources), now or in the near future.
The Guide is divided into seven sections, which comprise pharmacological targets of similar structure/function. These are 7TM receptors, transmitter-gated channels, ion channels, catalytic receptors, nuclear receptors, transporters and enzymes.
Citation Information:
We recommend that any citations to information in the Guide are presented in the following format:
Alexander, S.P.H., Mathie, A. & Peters, J.A. (2008). Guide to Receptors and Channels (GRAC), 3rd edition (2008). Br. J. Pharmacol., 153 (Suppl. 2), S1–S209.
Introduction
Guide to Receptors and Channels (GRAC), 3rd edition FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S1-S1
A key to the tables FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S3-S3
7TM Receptors
7TM receptors FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S4-S5
5-HT (5-Hydroxytryptamine) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S6-S8
Acetylcholine (muscarinic) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S9-S10
Adenosine FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S11-S12
Adiponectin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S13-S13
Adrenoceptors, 
1
FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S14-S14
Adrenoceptors, 2
FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S15-S15
Adrenoceptors, 
FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S16-S16
Anaphylatoxin and chemotactic peptide FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S17-S17
Angiotensin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S18-S18
Apelin FREE
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Br J Pharmacol S19-S19
Bile acid FREE
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Br J Pharmacol S20-S20
Bombesin FREE
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Br J Pharmacol S21-S21
Bradykinin FREE
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Br J Pharmacol S22-S22
Calcitonin, amylin, CGRP and adrenomedullin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S23-S24
Calcium-sensing FREE
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Br J Pharmacol S25-S25
Cannabinoid FREE
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Br J Pharmacol S26-S27
Chemokine FREE
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Br J Pharmacol S28-S30
Cholecystokinin FREE
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Br J Pharmacol S31-S31
Corticotropin-releasing factor FREE
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Br J Pharmacol S32-S33
Dopamine FREE
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Br J Pharmacol S34-S35
Endothelin FREE
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Br J Pharmacol S36-S37
Free fatty acid FREE
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Br J Pharmacol S38-S38
Frizzled FREE
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Br J Pharmacol S39-S40
Galanin FREE
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Br J Pharmacol S43-S44
Ghrelin FREE
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Br J Pharmacol S45-S45
Glucagon, glucagon-like peptide and secretin FREE
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Br J Pharmacol S46-S47
Glutamate, metabotropic FREE
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Br J Pharmacol S48-S50
Glycoprotein hormone FREE
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Br J Pharmacol S51-S51
Gonadotropin-releasing hormone (GnRH) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S52-S53
G-protein-coupled estrogen (GPE) FREE
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Br J Pharmacol S54-S54
Histamine FREE
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Br J Pharmacol S55-S55
KISS1, Neuropeptide FF, Prolactin-releasing peptide and QRFP FREE
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Br J Pharmacol S56-S57
Leukotriene, lipoxin, oxoeicosanoid and resolvin E1 FREE
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Br J Pharmacol S58-S60
Lysophosphatidic acid FREE
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Br J Pharmacol S61-S61
Melanin-concentrating hormone FREE
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Br J Pharmacol S62-S62
Melanocortin FREE
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Br J Pharmacol S63-S63
Melatonin FREE
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Br J Pharmacol S64-S65
Motilin FREE
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Br J Pharmacol S66-S66
Neuromedin U FREE
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Br J Pharmacol S67-S67
Neuropeptide S FREE
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Br J Pharmacol S68-S68
Neuropeptide Y FREE
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Br J Pharmacol S69-S69
Neuropeptides B and W FREE
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Br J Pharmacol S70-S70
Neurotensin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S71-S71
Nicotinic acid FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S72-S72
Opioid and opioid-like FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S73-S74
Orexin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S75-S75
Parathyroid hormone and parathyroid hormone-related peptide FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S78-S78
Platelet-activating factor FREE
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Br J Pharmacol S79-S79
Prostanoid FREE
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Br J Pharmacol S80-S81
Proteinase-activated FREE
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Br J Pharmacol S82-S82
Prokineticin FREE
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Br J Pharmacol S83-S83
Relaxin family peptide FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S84-S85
Somatostatin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S86-S86
Sphingosine-1-phosphate FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S87-S87
Tachykinin FREE
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Br J Pharmacol S88-S88
Trace amine-associated FREE
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Br J Pharmacol S89-S89
Urotensin-II FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S91-S92
Vasopressin & oxytocin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S93-S94
VIP & PACAP FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S95-S95
Transmitter-gated Channels
5-HT3 (5-Hydroxytryptamine3) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S96-S97
Acetylcholine (nicotinic) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S98-S100
GABAA (
-aminobutyric acid) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S101-S103
Glutamate (ionotropic) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S104-S106
Glycine FREE
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Br J Pharmacol S107-S108
ZAC (Zinc-activated) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S111-S111
Ion Channels
Acid-sensing (proton-gated) (ASICs) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S112-S113
Aquaporins FREE
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Br J Pharmacol S114-S114
Calcium (voltage-gated) FREE
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Br J Pharmacol S115-S116
CatSper FREE
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Br J Pharmacol S117-S117
Chloride FREE
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Br J Pharmacol S118-S122
Connexins and pannexins FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S123-S124
Cyclic nucleotide-gated FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S125-S125
Epithelial sodium (ENaC) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S126-S127
Hyperpolarisation-activated, cyclic nucleotide-gated (HCN) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S128-S128
IP3 receptor FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S129-S129
Potassium FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S130-S132
Ryanodine receptor FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S133-S133
Sodium (voltage-gated) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S134-S135
Transient receptor potential (TRP) cation FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S136-S145
Catalytic Receptors
ErbB family FREE
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Br J Pharmacol S146-S146
GDNF family FREE
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Br J Pharmacol S147-S147
Natriuretic peptide FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S148-S149
Neurotrophin FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S150-S150
Toll-like family FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S151-S152
Tumor necrosis factor (TNF) family FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S153-S154
Nuclear Receptors
Nuclear receptors FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S155-S155
Liver X and farnesoid X FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S156-S156
Peroxisome proliferator-activated FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S157-S158
Retinoic acid, retinoid X and retinoic acid-related orphan FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S159-S160
Steroid hormone FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S161-S162
Thyroid hormone FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S163-S163
Vitamin D, pregnene X and constitutive androstane FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S164-S164
Cell Surface Transmitter Transporters
Choline FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S165-S165
GABA FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S166-S167
Glutamate (excitatory amino acid) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S168-S169
Glycine FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S170-S171
Monoamine FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S172-S172
Nucleoside FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S173-S173
Enzymes
Adenosine metabolising enzymes FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S174-S174
Adenylyl cyclases (E.C. 4.6.1.1) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S175-S176
Amino acid hydroxylases (E.C.1.14.16.-) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S177-S177
Cyclooxygenase (E.C. 1.14.99.1) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S178-S178
Decarboxylases (E.C. 4.1.1.-) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S179-S179
Endocannabinoid metabolising enzymes FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S180-S181
Inositol monophosphatase (E.C. 3.1.3.25) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S182-S182
Lipoxygenases (E.C. 1.13.11.-) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S183-S183
Nitric oxide synthase (E.C. 1.14.13.39) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S184-S184
Phosphatidylcholine-specific phospholipase D (E.C. 3.1.4.4) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S185-S185
Phosphodiesterases, 3',5'-cyclic nucleotide (E.C. 3.1.4.17) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S186-S188
Phospholipase A2 (E.C. 3.1.1.4) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S189-S189
Phosphoinositide-specific phospholipase C (E.C. 3.1.4.11) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S190-S191
Protein serine/threonine kinases (E.C. 2.7.1.37) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S192-S195
Soluble guanylyl cyclase (E.C. 4.6.1.2) FREE
S P H Alexander, A Mathie and J A Peters
Br J Pharmacol S196-S196
