7TM Receptors

Subject Category: 7TM Receptors

Citation Information:
We recommend that any citations to information in the Guide are presented in the following format:

Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol153 (Suppl. 2): S1–S209.

Bile acid

S P H Alexander, A Mathie and J A Peters

Overview: The bile acid receptor (GPBA, provisional nomenclature) responds to bile acids produced during the liver metabolism of cholesterol.


Disruption of GPBA expression is reported to protect from cholesterol gallstone formation (Vassileva et al., 2006).

Keywords:

Lithocholic acid, deoxycholic acid, chenodeoxycholic acid, cholic acid, oleanolic acid, GPBA receptor, bile acid receptor

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References

Further Reading

  1. Houten SM, Watanabe M, Auwerx J (2006). Endocrine functions of bile acids. EMBO J 25: 1419–1425. | Article | PubMed | ISI | ChemPort |

References

  1. Kawamata Y et al. (2003). J Biol Chem 278: 9435–9440. | Article | PubMed | ISI | ChemPort |
  2. Maruyama T et al. (2002). Biochem Biophys Res Commun 298: 714–719. | Article | PubMed | ISI | ChemPort |
  3. Sato H et al. (2007). Biochem Biophys Res Commun 362: 793–798.
  4. Vassileva G et al. (2006). Biochem J 398: 423–430.

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