British Journal of Pharmacology

The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships

A A Fossa — April 21, 2008

The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships

British Journal of Pharmacology advance online publication, April 21, 2008. doi:10.1038/bjp.2008.123

Author: A A Fossa

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

G Michael — May 19, 2008

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

British Journal of Pharmacology advance online publication, May 19, 2008. doi:10.1038/bjp.2008.169

Authors: G Michael, K A Kane & S J Coker

Retraction: Sex differences in the expression of sodium/calcium exchanger influence the arrhythmia phenotype in the long QT syndrome type 2

G Salama — May 19, 2008

Retraction: Sex differences in the expression of sodium/calcium exchanger influence the arrhythmia phenotype in the long QT syndrome type 2

British Journal of Pharmacology advance online publication, May 19, 2008. doi:10.1038/bjp.2008.183

Authors: G Salama, B London, L J Kerchner, N R Salama & T Liu

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

I Wessler — May 26, 2008

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.185

Authors: I Wessler & C J Kirkpatrick

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

H R Lu — May 19, 2008

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

British Journal of Pharmacology advance online publication, May 19, 2008. doi:10.1038/bjp.2008.191

Authors: H R Lu, E Vlaminckx, A N Hermans, J Rohrbacher, K Van Ammel, R Towart, M Pugsley & D J Gallacher

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres

K Sakamoto — May 26, 2008

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.192

Authors: K Sakamoto, H Mikami & J Kimura

In vitro models of proarrhythmia

C L Lawrence — June 2, 2008

In vitro models of proarrhythmia

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.195

Authors: C L Lawrence, C E Pollard, T G Hammond & J-P Valentin

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

A Matagne — May 26, 2008

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.198

Authors: A Matagne, D-G Margineanu, B Kenda, P Michel & H Klitgaard

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

C E Pollard — May 26, 2008

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.203

Authors: C E Pollard, J-P Valentin & T G Hammond

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

B M Jensen — May 26, 2008

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.204

Authors: B M Jensen, C Akin & A M Gilfillan

Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats

L Jolly — May 26, 2008

Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats

British Journal of Pharmacology advance online publication, May 26, 2008. doi:10.1038/bjp.2008.205

Authors: L Jolly, J E March, P A Kemp, T Bennett & S M Gardiner

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

J J Lynch — June 2, 2008

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.206

Authors: J J Lynch, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox & S W Mittelstadt

Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK

A R Green — June 2, 2008

Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.207

Author: A R Green

Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use

G D'Agostino — June 2, 2008

Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.208

Authors: G D'Agostino, A M Condino, L Gioglio, F Zonta, M Tonini & A Barbieri

Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

T Christ — June 9, 2008

Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.209

Authors: T Christ, E Wettwer, N Voigt, O Hála, S Radicke, K Matschke, A Várro, D Dobrev & U Ravens

Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects

M I Mohammed Abdul — June 2, 2008

Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.210

Authors: M I Mohammed Abdul, X Jiang, K M Williams, R O Day, B D Roufogalis, W S Liauw, H Xu & A J McLachlan

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5

D De Filippis — June 16, 2008

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.211

Authors: D De Filippis, A Russo, A D'Amico, G Esposito, P Concetta, M Cinelli, G Russo & T Iuvone

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

J Gierten — June 2, 2008

Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.213

Authors: J Gierten, E Ficker, R Bloehs, K Schlömer, S Kathöfer, E Scholz, E Zitron, C Kiesecker, A Bauer, R Becker, H A Katus, C A Karle & D Thomas

Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype

N Foudi — June 2, 2008

Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: role of the EP4 receptor subtype

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.214

Authors: N Foudi, L Kotelevets, L Louedec, G Leséche, D Henin, E Chastre & X Norel

Moving towards better predictors of drug-induced torsades de pointes

A S Bass — June 23, 2008

Moving towards better predictors of drug-induced torsades de pointes

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.215

Authors: A S Bass, B Darpo, J-P Valentin, P Sager & K Thomas

Arachidonic acid and ion channels: an update

H Meves — June 16, 2008

Arachidonic acid and ion channels: an update

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.216

Author: H Meves

Characterization of the α1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter

K A Mills — June 2, 2008

Characterization of the α1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter

British Journal of Pharmacology advance online publication, June 2, 2008. doi:10.1038/bjp.2008.217

Authors: K A Mills, N Hausman & R Chess-Williams

Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors

M Mączewski — June 9, 2008

Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.218

Authors: M Mączewski, J Mączewska & M Duda

CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

K D Vandegriff — June 9, 2008

CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.219

Authors: K D Vandegriff, M A Young, J Lohman, A Bellelli, M Samaja, A Malavalli & R M Winslow

Brivaracetam: a rational drug discovery success story

M A Rogawski — June 16, 2008

Brivaracetam: a rational drug discovery success story

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.221

Author: M A Rogawski

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

P T Sager — June 9, 2008

Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.222

Author: P T Sager

Anti-inflammatory actions of aprotinin provide dose-dependent cardioprotection from reperfusion injury

J M Carter — June 9, 2008

Anti-inflammatory actions of aprotinin provide dose-dependent cardioprotection from reperfusion injury

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.223

Authors: J M Carter, U Buerke, E Rössner, M Russ, S Schubert, H Schmidt, H Ebelt, D Pruefer, A Schlitt, K Werdan & M Buerke

The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts

P Almela — June 9, 2008

The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.224

Authors: P Almela, M V Milanés & M L Laorden

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice

S Y İnan — June 9, 2008

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.225

Authors: S Y İnan & K Büyükafşar

Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors

J Gupta — June 16, 2008

Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V1A receptors and not oxytocin receptors

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.226

Authors: J Gupta, R J Russell, C P Wayman, D Hurley & V M Jackson

Blockade of adenosine A2B receptors ameliorates murine colitis

V L Kolachala — June 9, 2008

Blockade of adenosine A2B receptors ameliorates murine colitis

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.227

Authors: V L Kolachala, B K Ruble, M Vijay-Kumar, L Wang, S Mwangi, H E Figler, R A Figler, S Srinivasan, A T Gewirtz, J Linden, D Merlin & S V Sitaraman

A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems

R N Upton — June 16, 2008

A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.228

Authors: R N Upton, A M Martinez & C Grant

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

M J Forrest — June 9, 2008

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.229

Authors: M J Forrest, D Bloomfield, R J Briscoe, P N Brown, A-M Cumiskey, J Ehrhart, J C Hershey, W J Keller, X Ma, H E McPherson, E Messina, L B Peterson, W Sharif-Rodriguez, P K S Siegl, P J Sinclair, C P Sparrow, A S Stevenson, S-Y Sun, C Tsai, H Vargas, M Walker, S H West, V White & R F Woltmann

Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor

B Bosier — June 9, 2008

Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB1 receptor

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.230

Authors: B Bosier, E Hermans & D M Lambert

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents

S Y M Yeung — June 9, 2008

Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.231

Authors: S Y M Yeung, M Schwake, V Pucovský & I A Greenwood

Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells

A Banerjee — June 16, 2008

Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.232

Authors: A Banerjee, G Damera, R Bhandare, S Gu, Y S Lopez-Boado, R A Panettieri & O Tliba

On the fitting of binding data when receptor dimerization is suspected

J Giraldo — June 9, 2008

On the fitting of binding data when receptor dimerization is suspected

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.234

Author: J Giraldo

Low concentrations of tetrodotoxin interact with tetrodotoxin-resistant voltage-gated sodium channels

C E Farmer — June 16, 2008

Low concentrations of tetrodotoxin interact with tetrodotoxin-resistant voltage-gated sodium channels

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.235

Authors: C E Farmer, K J Smith & R J Docherty

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

T Šimůnek — June 9, 2008

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.236

Authors: T Šimůnek, M Štěrba, O Popelová, H Kaiserová, M Adamcová, M Hroch, P Hašková, P Poňka & V Geršl

Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids

L Thors — June 16, 2008

Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.237

Authors: L Thors, M Belghiti & C J Fowler

Cellular basis of drug-induced torsades de pointes

D M Roden — June 16, 2008

Cellular basis of drug-induced torsades de pointes

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.238

Author: D M Roden

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

M Oka — June 9, 2008

Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.239

Authors: M Oka, K A Fagan, P L Jones & I F McMurtry

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

A Sugiyama — June 16, 2008

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.240

Author: A Sugiyama

Pulmonary hypertension: therapeutic targets within the serotonin system

Y Dempsie — June 9, 2008

Pulmonary hypertension: therapeutic targets within the serotonin system

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.241

Authors: Y Dempsie & M R MacLean

Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures

C-Y Hsiang — June 16, 2008

Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.242

Authors: C-Y Hsiang & T-Y Ho

Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice

M Kreilgaard — June 16, 2008

Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.243

Authors: M Kreilgaard, D G Smith, L T Brennum & C Sánchez

Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2-adrenoceptor mechanisms

R A Ngala — June 16, 2008

Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and β2-adrenoceptor mechanisms

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.244

Authors: R A Ngala, J O'Dowd, S J Wang, A Agarwal, C Stocker, M A Cawthorne & J R S Arch

The α1A-adrenoceptor gene is required for the α1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate

K T Gray — June 16, 2008

The α1A-adrenoceptor gene is required for the α1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.245

Authors: K T Gray, J L Short & S Ventura

Interactions between CB1 receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons

S R Kim — June 16, 2008

Interactions between CB1 receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.246

Authors: S R Kim, E Bok, Y C Chung, E S Chung & B K Jin

Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats

K Budzyn — June 16, 2008

Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.247

Authors: K Budzyn, R M Ravi, A A Miller & C G Sobey

The failure of torcetrapib: what have we learned?

T R Joy — June 9, 2008

The failure of torcetrapib: what have we learned?

British Journal of Pharmacology advance online publication, June 9, 2008. doi:10.1038/bjp.2008.248

Authors: T R Joy & R A Hegele

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery

T P Barros — June 16, 2008

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery

British Journal of Pharmacology advance online publication, June 16, 2008. doi:10.1038/bjp.2008.249

Authors: T P Barros, W K Alderton, H M Reynolds, A G Roach & S Berghmans

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

F D'Acquisto — July 21, 2008

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

British Journal of Pharmacology advance online publication, July 21, 2008. doi:10.1038/bjp.2008.252

Authors: F D'Acquisto, M Perretti & R J Flower

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

K L Aughton — June 30, 2008

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.253

Authors: K L Aughton, K Hamilton-Smith, J Gupta, J S Morton, C P Wayman & V M Jackson

Epigenetic biomarkers in psychiatric disorders

J Peedicayil — June 23, 2008

Epigenetic biomarkers in psychiatric disorders

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.254

Author: J Peedicayil

High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues

G Haeseler — June 23, 2008

High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.255

Authors: G Haeseler, M Karst, N Foadi, S Gudehus, A Roeder, H Hecker, R Dengler & M Leuwer

Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat

F S Michel — June 23, 2008

Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.256

Authors: F S Michel, G S Man, R Y K Man & P M Vanhoutte

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

I Verbaeys — June 23, 2008

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.257

Authors: I Verbaeys, F León-Tamariz, H Pottel, E Decuypere, Q Swennen & M Cokelaere

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells

M E Callister — June 30, 2008

PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-κB-dependent proinflammatory activation of alveolar epithelial cells

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.258

Authors: M E Callister, L Pinhu, M C Catley, A D Westwell, R Newton, S K Leaver, G J Quinlan, T W Evans, M J Griffiths & A Burke-Gaffney

Effects of pregabalin on visceral pain responses and colonic compliance in rats

A Ravnefjord — June 23, 2008

Effects of pregabalin on visceral pain responses and colonic compliance in rats

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.259

Authors: A Ravnefjord, M Brusberg, H Larsson, E Lindström & V Martínez

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

A Régina — June 23, 2008

Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.260

Authors: A Régina, M Demeule, C Ché, I Lavallée, J Poirier, R Gabathuler, R Béliveau & J-P Castaigne

The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels

Q Tang — June 23, 2008

The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.261

Authors: Q Tang, Z-Q Li, W Li, J Guo, H-Y Sun, X-H Zhang, C-P Lau, H-F Tse, S Zhang & G-R Li

Raloxifene protects endothelial cell function against oxidative stress

C M Wong — June 23, 2008

Raloxifene protects endothelial cell function against oxidative stress

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.262

Authors: C M Wong, L M Yung, F P Leung, S-Y Tsang, C L Au, Z-Y Chen, X Yao, C H K Cheng, C-W Lau, M Gollasch & Y Huang

The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles

B Mayer — June 23, 2008

The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.263

Authors: B Mayer & M Beretta

The α1L-adrenoceptor is an alternative phenotype of the α1A-adrenoceptor

C P Nelson — June 23, 2008

The α1L-adrenoceptor is an alternative phenotype of the α1A-adrenoceptor

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.264

Author: C P Nelson

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction

H J van der Linde — June 23, 2008

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction

British Journal of Pharmacology advance online publication, June 23, 2008. doi:10.1038/bjp.2008.265

Authors: H J van der Linde, B Van Deuren, A Teisman, R Towart & D J Gallacher

Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

D J Behm — June 30, 2008

Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.266

Authors: D J Behm, J J McAtee, J W Dodson, M J Neeb, H E Fries, C A Evans, R R Hernandez, K D Hoffman, S M Harrison, J M Lai, C Wu, N V Aiyar, E H Ohlstein & S A Douglas

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

X Yao — June 30, 2008

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.267

Authors: X Yao, D L Anderson, S A Ross, D G Lang, B Z Desai, D C Cooper, P Wheelan, M S McIntyre, M L Bergquist, K I MacKenzie, J D Becherer & M A Hashim

Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation

R Colucci — June 30, 2008

Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.268

Authors: R Colucci, C Blandizzi, N Ghisu, T Florio & M Del Tacca

Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase

M Oppermann — June 30, 2008

Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.269

Authors: M Oppermann, V T-V Dao, T Suvorava, M Bas & G Kojda

Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice

A Zarbock — June 30, 2008

Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.270

Authors: A Zarbock, M Allegretti & K Ley

Estimating the efficiency of benzodiazepines on GABAA receptors comprising γ1 or γ2 subunits

I Baburin — July 7, 2008

Estimating the efficiency of benzodiazepines on GABAA receptors comprising γ1 or γ2 subunits

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.271

Authors: I Baburin, S Khom, E Timin, A Hohaus, W Sieghart & S Hering

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

L Xia — June 30, 2008

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.272

Authors: L Xia, X X Wang, X S Hu, X G Guo, Y P Shang, H J Chen, C L Zeng, F R Zhang & J Z Chen

Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat

Y Mbaki — July 7, 2008

Investigation of the role of 5-HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.273

Authors: Y Mbaki & A G Ramage

Cancer and the blood–brain barrier: ‘Trojan horses’ for courses?

M Mazza — June 30, 2008

Cancer and the blood–brain barrier: ‘Trojan horses’ for courses?

British Journal of Pharmacology advance online publication, June 30, 2008. doi:10.1038/bjp.2008.274

Authors: M Mazza, I F Uchegbu & A G Schätzlein

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

T M Haushalter — July 7, 2008

The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.275

Authors: T M Haushalter, G S Friedrichs, D L Reynolds, M Barecki-Roach, G Pastino, R Hayes & A S Bass

Smooth muscle α1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles

W F Jackson — July 7, 2008

Smooth muscle α1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca2+ in hamster cremaster arterioles

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.276

Authors: W F Jackson, E M Boerman, E J Lange, S S Lundback & K D Cohen

Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability

M A Vos — July 7, 2008

Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.277

Author: M A Vos

α2-Adrenoceptor action on cell proliferation and mammary tumour growth in mice

A Bruzzone — July 7, 2008

α2-Adrenoceptor action on cell proliferation and mammary tumour growth in mice

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.278

Authors: A Bruzzone, C Pérez Piñero, L F Castillo, M G Sarappa, P Rojas, C Lanari & I A Lüthy

Principles of Safety Pharmacology

M K Pugsley — July 7, 2008

Principles of Safety Pharmacology

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.280

Authors: M K Pugsley, S Authier & M J Curtis

Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat

B Marcos — July 14, 2008

Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat

British Journal of Pharmacology advance online publication, July 14, 2008. doi:10.1038/bjp.2008.281

Authors: B Marcos, T T Chuang, F J Gil-Bea & M J Ramirez

Production of a specific extracellular inhibitor of TRPM3 channels

J Naylor — July 7, 2008

Production of a specific extracellular inhibitor of TRPM3 channels

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.283

Authors: J Naylor, C J Milligan, F Zeng, C Jones & D J Beech

Novel long-acting bronchodilators for COPD and asthma

M Cazzola — July 7, 2008

Novel long-acting bronchodilators for COPD and asthma

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.284

Authors: M Cazzola & M G Matera

Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

J Reutenauer — July 21, 2008

Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

British Journal of Pharmacology advance online publication, July 21, 2008. doi:10.1038/bjp.2008.285

Authors: J Reutenauer, O M Dorchies, O Patthey-Vuadens, G Vuagniaux & U T Ruegg

Dietary trace amine-dependent vasoconstriction in porcine coronary artery

A A Herbert — July 7, 2008

Dietary trace amine-dependent vasoconstriction in porcine coronary artery

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.286

Authors: A A Herbert, E J Kidd & K J Broadley

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

K M Waldhauser — July 7, 2008

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.287

Authors: K M Waldhauser, K Brecht, S Hebeisen, H R Ha, D Konrad, D Bur & S Krähenbühl

Bradykinin regulates human colonic ion transport in vitro

A W Baird — July 7, 2008

Bradykinin regulates human colonic ion transport in vitro

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.288

Authors: A W Baird, M M Skelly, D P O'Donoghue, K E Barrett & S J Keely

Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide

R Rodriguez-Rodriguez — July 14, 2008

Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide

British Journal of Pharmacology advance online publication, July 14, 2008. doi:10.1038/bjp.2008.289

Authors: R Rodriguez-Rodriguez, E Stankevicius, M D Herrera, L Østergaard, M R Andersen, V Ruiz-Gutierrez & U Simonsen

Targeting airway inflammation: PMX464 and the epithelial bulls eye

D W Sexton — July 7, 2008

Targeting airway inflammation: PMX464 and the epithelial bulls eye

British Journal of Pharmacology advance online publication, July 7, 2008. doi:10.1038/bjp.2008.290

Author: D W Sexton

Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus

E K Weir — July 21, 2008

Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus

British Journal of Pharmacology advance online publication, July 21, 2008. doi:10.1038/bjp.2008.291

Authors: E K Weir, M Obreztchikova, A Vargese, J A Cabrera, D A Peterson & Z Hong