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Commentaries

July 21 2008

Atypical pharmacologies at -adrenoceptors FREE

R J Summers

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.293

Abstract | Full Text | PDF

July 7 2008

Targeting airway inflammation: PMX464 and the epithelial bulls eye FREE

D W Sexton

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.290

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June 30 2008

Cancer and the blood–brain barrier: 'Trojan horses' for courses? FREE

M Mazza, I F Uchegbu and A G Schätzlein

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.274

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June 23 2008

The _1L-adrenoceptor is an alternative phenotype of the _1A-adrenoceptor FREE

C P Nelson

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.264

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Epigenetic biomarkers in psychiatric disorders FREE

J Peedicayil

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.254

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June 16 2008

Brivaracetam: a rational drug discovery success story FREE

M A Rogawski

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.221

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June 9 2008

The failure of torcetrapib: what have we learned? FREE

T R Joy and R A Hegele

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.248

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Reviews

July 21 2008

Annexin-A1: a pivotal regulator of the innate and adaptive immune systems

F D'Acquisto, M Perretti and R J Flower

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.252

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Mechanisms of oxygen sensing: a key to therapy of pulmonary hypertension and patent ductus arteriosus

E K Weir, M Obreztchikova, A Vargese, J A Cabrera, D A Peterson and Z Hong

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.291

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July 7 2008

Novel long-acting bronchodilators for COPD and asthma

M Cazzola and M G Matera

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.284

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Principles of Safety Pharmacology

M K Pugsley, S Authier and M J Curtis

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.280

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Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability

M A Vos

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.277

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June 23 2008

Moving towards better predictors of drug-induced torsades de pointes

A S Bass, B Darpo, J-P Valentin, P Sager and K Thomas

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.215

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The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles

B Mayer and M Beretta

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.263

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June 16 2008

Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery

T P Barros, W K Alderton, H M Reynolds, A G Roach and S Berghmans

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.249

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Arachidonic acid and ion channels: an update

H Meves

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.216

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Cellular basis of drug-induced torsades de pointes

D M Roden

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.238

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Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

A Sugiyama

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.240

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June 9 2008

Pulmonary hypertension: therapeutic targets within the serotonin system

Y Dempsie and M R MacLean

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.241

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On the fitting of binding data when receptor dimerization is suspected

J Giraldo

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.234

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Therapeutic potential of RhoA/Rho kinase inhibitors in pulmonary hypertension

M Oka, K A Fagan, P L Jones and I F McMurtry

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.239

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Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes

P T Sager

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.222

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June 2 2008

Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK

A R Green

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.207

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In vitro models of proarrhythmia

C L Lawrence, C E Pollard, T G Hammond and J-P Valentin

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.195

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May 26 2008

Pharmacological targeting of the KIT growth factor receptor: a therapeutic consideration for mast cell disorders

B M Jensen, C Akin and A M Gilfillan

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.204

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Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

C E Pollard, J-P Valentin and T G Hammond

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.203

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Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

I Wessler and C J Kirkpatrick

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.185

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April 21 2008

The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships

A A Fossa

Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.123

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Research Papers

July 21 2008

Biosynthesis of H₂S is impaired in non-obese diabetic (NOD) mice

V Brancaleone, F Roviezzo, V Vellecco, L De Gruttola, M Bucci and G Cirino

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.296

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Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone

H J Leis and W Windischhofer

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.304

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Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

J Reutenauer, O M Dorchies, O Patthey-Vuadens, G Vuagniaux and U T Ruegg

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.285

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₁-Adrenoceptors in the lateral septal area modulate food intake behaviour in rats

A A Scopinho, L B M Resstel and F M A Corrêa

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.295

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YC-1 induces apoptosis of human renal carcinoma A498 cells in vitro and in vivo through activation of the JNK pathway

S Y Wu, S L Pan, T H Chen, C H Liao, D Y Huang, J H Guh, Y L Chang, S C Kuo, F Y Lee and C M Teng

Br J Pharmacol advance online publication, July 21, 2008; doi:10.1038/bjp.2008.292

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July 14 2008

Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between -opioid and cannabinoid CB₁ receptors

R Capasso, F Borrelli, M G Cascio, G Aviello, K Huben, J K Zjawiony, P Marini, B Romano, V Di Marzo, F Capasso and A A Izzo

Br J Pharmacol advance online publication, July 14, 2008; doi:10.1038/bjp.2008.294

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Effects of 5-HT₆ receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat

B Marcos, T T Chuang, F J Gil-Bea and M J Ramirez

Br J Pharmacol advance online publication, July 14, 2008; doi:10.1038/bjp.2008.281

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Oleanolic acid induces relaxation and calcium-independent release of endothelium-derived nitric oxide

R Rodriguez-Rodriguez, E Stankevicius, M D Herrera, L Østergaard, M R Andersen, V Ruiz-Gutierrez and U Simonsen

Br J Pharmacol advance online publication, July 14, 2008; doi:10.1038/bjp.2008.289

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July 7 2008

Estimating the efficiency of benzodiazepines on GABA_A receptors comprising 1 or 2 subunits ^BJPOpen

I Baburin, S Khom, E Timin, A Hohaus, W Sieghart and S Hering

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.271

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Bradykinin regulates human colonic ion transport in vitro

A W Baird, M M Skelly, D P O'Donoghue, K E Barrett and S J Keely

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.288

Abstract | Full Text | PDF

₂-Adrenoceptor action on cell proliferation and mammary tumour growth in mice

A Bruzzone, C Pérez Piñero, L F Castillo, M G Sarappa, P Rojas, C Lanari and I A Lüthy

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.278

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The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys

T M Haushalter, G S Friedrichs, D L Reynolds, M Barecki-Roach, G Pastino, R Hayes and A S Bass

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.275

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Dietary trace amine-dependent vasoconstriction in porcine coronary artery

A A Herbert, E J Kidd and K J Broadley

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.286

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Smooth muscle _1D-adrenoceptors mediate phenylephrine-induced vasoconstriction and increases in endothelial cell Ca²⁺ in hamster cremaster arterioles

W F Jackson, E M Boerman, E J Lange, S S Lundback and K D Cohen

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.276

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Investigation of the role of 5-HT₂ receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat

Y Mbaki and A G Ramage

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.273

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Production of a specific extracellular inhibitor of TRPM3 channels

J Naylor, C J Milligan, F Zeng, C Jones and D J Beech

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.283

Abstract | Full Text | PDF | Supplementary information

Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues

K M Waldhauser, K Brecht, S Hebeisen, H R Ha, D Konrad, D Bur and S Krähenbühl

Br J Pharmacol advance online publication, July 7, 2008; doi:10.1038/bjp.2008.287

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June 30 2008

Pharmacological profiling of neuropeptides on rabbit vaginal wall and vaginal artery smooth muscle in vitro

K L Aughton, K Hamilton-Smith, J Gupta, J S Morton, C P Wayman and V M Jackson

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.253

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Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues

D J Behm, J J McAtee, J W Dodson, M J Neeb, H E Fries, C A Evans, R R Hernandez, K D Hoffman, S M Harrison, J M Lai, C Wu, N V Aiyar, E H Ohlstein and S A Douglas

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.266

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PMX464, a thiol-reactive quinol and putative thioredoxin inhibitor, inhibits NF-B-dependent proinflammatory activation of alveolar epithelial cells ^BJPOpen

M E Callister, L Pinhu, M C Catley, A D Westwell, R Newton, S K Leaver, G J Quinlan, T W Evans, M J Griffiths and A Burke-Gaffney

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.258

Abstract | Full Text | PDF

Somatostatin inhibits colon cancer cell growth through cyclooxygenase-2 downregulation

R Colucci, C Blandizzi, N Ghisu, T Florio and M Del Tacca

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.268

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Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase

M Oppermann, V T-V Dao, T Suvorava, M Bas and G Kojda

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.269

Abstract | Full Text | PDF | Supplementary information

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

L Xia, X X Wang, X S Hu, X G Guo, Y P Shang, H J Chen, C L Zeng, F R Zhang and J Z Chen

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.272

Abstract | Full Text | PDF

Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model ^BJPOpen

X Yao, D L Anderson, S A Ross, D G Lang, B Z Desai, D C Cooper, P Wheelan, M S McIntyre, M L Bergquist, K I MacKenzie, J D Becherer and M A Hashim

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.267

Abstract | Full Text | PDF | Supplementary information

Therapeutic inhibition of CXCR2 by Reparixin attenuates acute lung injury in mice

A Zarbock, M Allegretti and K Ley

Br J Pharmacol advance online publication, June 30, 2008; doi:10.1038/bjp.2008.270

Abstract | Full Text | PDF

June 23 2008

High-affinity blockade of voltage-operated skeletal muscle and neuronal sodium channels by halogenated propofol analogues

G Haeseler, M Karst, N Foadi, S Gudehus, A Roeder, H Hecker, R Dengler and M Leuwer

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.255

Abstract | Full Text | PDF | Supplementary information

Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat

F S Michel, G S Man, R Y K Man and P M Vanhoutte

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.256

Abstract | Full Text | PDF

Effects of pregabalin on visceral pain responses and colonic compliance in rats

A Ravnefjord, M Brusberg, H Larsson, E Lindström and V Martínez

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.259

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Antitumour activity of ANG1005, a conjugate between paclitaxel and the new brain delivery vector Angiopep-2

A Régina, M Demeule, C Ché, I Lavallée, J Poirier, R Gabathuler, R Béliveau and J-P Castaigne

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.260

Abstract | Full Text | PDF

The 5-HT₂ antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels

Q Tang, Z-Q Li, W Li, J Guo, H-Y Sun, X-H Zhang, C-P Lau, H-F Tse, S Zhang and G-R Li

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.261

Abstract | Full Text | PDF

PEGylated cholecystokinin is more potent in inducing anorexia than conditioned taste aversion in rats

I Verbaeys, F León-Tamariz, H Pottel, E Decuypere, Q Swennen and M Cokelaere

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.257

Abstract | Full Text | PDF

Raloxifene protects endothelial cell function against oxidative stress

C M Wong, L M Yung, F P Leung, S-Y Tsang, C L Au, Z-Y Chen, X Yao, C H K Cheng, C-W Lau, M Gollasch and Y Huang

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.262

Abstract | Full Text | PDF

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction ^BJPOpen

H J van der Linde, B Van Deuren, A Teisman, R Towart and D J Gallacher

Br J Pharmacol advance online publication, June 23, 2008; doi:10.1038/bjp.2008.265

Abstract | Full Text | PDF

June 16 2008

Vitamin D and glucocorticoids differentially modulate chemokine expression in human airway smooth muscle cells ^BJPOpen

A Banerjee, G Damera, R Bhandare, S Gu, Y S Lopez-Boado, R A Panettieri Jr and O Tliba

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.232

Abstract | Full Text | PDF

Mechanisms of augmented vasoconstriction induced by 5-hydroxytryptamine in aortic rings from spontaneously hypertensive rats

K Budzyn, R M Ravi, A A Miller and C G Sobey

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.247

Abstract | Full Text | PDF

Cannabinoids reduce granuloma-associated angiogenesis in rats by controlling transcription and expression of mast cell protease-5

D De Filippis, A Russo, A D'Amico, G Esposito, P Concetta, M Cinelli, G Russo and T Iuvone

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.211

Abstract | Full Text | PDF

Low concentrations of tetrodotoxin interact with tetrodotoxin-resistant voltage-gated sodium channels

C E Farmer, K J Smith and R J Docherty

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.235

Abstract | Full Text | PDF

The _1A-adrenoceptor gene is required for the _1L-adrenoceptor-mediated response in isolated preparations of the mouse prostate

K T Gray, J L Short and S Ventura

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.245

Abstract | Full Text | PDF

Oxytocin-induced contractions within rat and rabbit ejaculatory tissues are mediated by vasopressin V_1A receptors and not oxytocin receptors

J Gupta, R J Russell, C P Wayman, D Hurley and V M Jackson

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.226

Abstract | Full Text | PDF

Emodin is a novel alkaline nuclease inhibitor that suppresses herpes simplex virus type 1 yields in cell cultures

C-Y Hsiang and T-Y Ho

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.242

Abstract | Full Text | PDF

Interactions between CB₁ receptors and TRPV1 channels mediated by 12-HPETE are cytotoxic to mesencephalic dopaminergic neurons

S R Kim, E Bok, Y C Chung, E S Chung and B K Jin

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.246

Abstract | Full Text | PDF

Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice

M Kreilgaard, D G Smith, L T Brennum and C Sánchez

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.243

Abstract | Full Text | PDF

Metabolic responses to BRL37344 and clenbuterol in soleus muscle and C2C12 cells via different atypical pharmacologies and ₂-adrenoceptor mechanisms

R A Ngala, J O'Dowd, S J Wang, A Agarwal, C Stocker, M A Cawthorne and J R S Arch

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.244

Abstract | Full Text | PDF

Inhibition of fatty acid amide hydrolase by kaempferol and related naturally occurring flavonoids

L Thors, M Belghiti and C J Fowler

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.237

Abstract | Full Text | PDF

A dose escalation study in sheep of the effects of the benzodiazepine CNS 7056 on sedation, the EEG and the respiratory and cardiovascular systems

R N Upton, A M Martinez and C Grant

Br J Pharmacol advance online publication, June 16, 2008; doi:10.1038/bjp.2008.228

Abstract | Full Text | PDF

June 9 2008

The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts

P Almela, M V Milanés and M L Laorden

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.224

Abstract | Full Text | PDF

Differential modulation of AP-1- and CRE-driven transcription by cannabinoid agonists emphasizes functional selectivity at the CB₁ receptor

B Bosier, E Hermans and D M Lambert

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.230

Abstract | Full Text | PDF

Anti-inflammatory actions of aprotinin provide dose-dependent cardioprotection from reperfusion injury

J M Carter, U Buerke, E Rössner, M Russ, S Schubert, H Schmidt, H Ebelt, D Pruefer, A Schlitt, K Werdan and M Buerke

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.223

Abstract | Full Text | PDF

Pathology-specific effects of the I _Kur/I _to/I _K,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation

T Christ, E Wettwer, N Voigt, O Hála, S Radicke, K Matschke, A Várro, D Dobrev and U Ravens

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.209

Abstract | Full Text | PDF | Supplementary information

Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone ^BJPOpen

M J Forrest, D Bloomfield, R J Briscoe, P N Brown, A-M Cumiskey, J Ehrhart, J C Hershey, W J Keller, X Ma, H E McPherson, E Messina, L B Peterson, W Sharif-Rodriguez, P K S Siegl, P J Sinclair, C P Sparrow, A S Stevenson, S-Y Sun, C Tsai, H Vargas, M Walker III, S H West, V White and R F Woltmann

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.229

Abstract | Full Text | PDF | Supplementary information

Blockade of adenosine A_2B receptors ameliorates murine colitis ^BJPOpen

V L Kolachala, B K Ruble, M Vijay-Kumar, L Wang, S Mwangi, H E Figler, R A Figler, S Srinivasan, A T Gewirtz, J Linden, D Merlin and S V Sitaraman

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.227

Abstract | Full Text | PDF

Hypercholesterolaemia exacerbates ventricular remodelling after myocardial infarction in the rat: role of angiotensin II type 1 receptors

M Mczewski, J Mczewska and M Duda

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.218

Abstract | Full Text | PDF

CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats

K D Vandegriff, M A Young, J Lohman, A Bellelli, M Samaja, A Malavalli and R M Winslow

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.219

Abstract | Full Text | PDF

Bimodal effects of the K_v7 channel activator retigabine on vascular K⁺ currents

S Y M Yeung, M Schwake, V Pucovský and I A Greenwood

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.231

Abstract | Full Text | PDF

Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice

S Y nan and K Büyükafar

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.225

Abstract | Full Text | PDF

Anthracycline toxicity to cardiomyocytes or cancer cells is differently affected by iron chelation with salicylaldehyde isonicotinoyl hydrazone

T imnek, M trba, O Popelová, H Kaiserová, M Adamcová, M Hroch, P Haková, P Poka and V Gerl

Br J Pharmacol advance online publication, June 9, 2008; doi:10.1038/bjp.2008.236

Abstract | Full Text | PDF

June 2 2008

Isolated porcine bronchi provide a reliable model for development of bronchodilator anti-muscarinic agents for human use

G D'Agostino, A M Condino, L Gioglio, F Zonta, M Tonini and A Barbieri

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.208

Abstract | Full Text | PDF

Vasorelaxation induced by prostaglandin E₂ in human pulmonary vein: role of the EP₄ receptor subtype

N Foudi, L Kotelevets, L Louedec, G Leséche, D Henin, E Chastre and X Norel

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.214

Abstract | Full Text | PDF

Regulation of two-pore-domain (K_2P) potassium leak channels by the tyrosine kinase inhibitor genistein

J Gierten, E Ficker, R Bloehs, K Schlömer, S Kathöfer, E Scholz, E Zitron, C Kiesecker, A Bauer, R Becker, H A Katus, C A Karle and D Thomas

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.213

Abstract | Full Text | PDF

Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys

J J Lynch III, A W Wilson, L E Hernandez, R A Nelson, K C Marsh, B F Cox and S W Mittelstadt

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.206

Abstract | Full Text | PDF

Characterization of the ₁-adrenoceptor subtype mediating contractions of the pig internal anal sphincter

K A Mills, N Hausman and R Chess-Williams

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.217

Abstract | Full Text | PDF

Pharmacodynamic interaction of warfarin with cranberry but not with garlic in healthy subjects

M I Mohammed Abdul, X Jiang, K M Williams, R O Day, B D Roufogalis, W S Liauw, H Xu and A J McLachlan

Br J Pharmacol advance online publication, June 2, 2008; doi:10.1038/bjp.2008.210

Abstract | Full Text | PDF

May 26 2008

Regional haemodynamic responses to adenosine receptor activation vary across time following lipopolysaccharide treatment in conscious rats ^BJPOpen

L Jolly, J E March, P A Kemp, T Bennett and S M Gardiner

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.205

Abstract | Full Text | PDF

Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A

A Matagne, D-G Margineanu, B Kenda, P Michel and H Klitgaard

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.198

Abstract | Full Text | PDF

Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres

K Sakamoto, H Mikami and J Kimura

Br J Pharmacol advance online publication, May 26, 2008; doi:10.1038/bjp.2008.192

Abstract | Full Text | PDF | Supplementary information

May 19 2008

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines ^BJPOpen

H R Lu, E Vlaminckx, A N Hermans, J Rohrbacher, K Van Ammel, R Towart, M Pugsley and D J Gallacher

Br J Pharmacol advance online publication, May 19, 2008; doi:10.1038/bjp.2008.191

Abstract | Full Text | PDF

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

G Michael, K A Kane and S J Coker

Br J Pharmacol advance online publication, May 19, 2008; doi:10.1038/bjp.2008.169

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Retraction: Sex differences in the expression of sodium/calcium exchanger influence the arrhythmia phenotype in the long QT syndrome type 2

G Salama, B London, L J Kerchner, N R Salama and T Liu

Br J Pharmacol advance online publication, May 19, 2008; doi:10.1038/bjp.2008.183

Abstract