ADVANCE ONLINE PUBLICATION
The latest research papers, published online ahead of print. These online versions are definitive and may be cited using the digital object identifier (DOI).
About advance online publication
May 5 2008 |
April 28 2008 |
April 21 2008 |
April 14 2008 |
March 31 2008 |
March 24 2008
May 12 2008
Review
The histamine H3 receptor: an attractive target for the treatment of cognitive disorders
T A Esbenshade, K E Browman, R S Bitner, M Strakhova, M D Cowart and J D Brioni
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.147
Research Papers
Increased susceptibility of annexin-A1 null mice to nociceptive pain is indicative of a spinal antinociceptive action of annexin-A1
S S Ayoub, S Yazid and R J Flower
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.166
Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice
R Capasso, F Borrelli, G Aviello, B Romano, C Scalisi, F Capasso and A A Izzo
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.177
Brain oxytocin receptors mediate ejaculation elicited by 7-hydroxy-2-(di-N-propylamino) tetralin (7-OH-DPAT) in anaesthetized rats
P Clément, M Peeters, J Bernabé, P Denys, L Alexandre and F Giuliano
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.176
In vivo pharmacological evaluation of compound 48/80-induced airways oedema by MRI
H Karmouty-Quintana, F-X Blé, C Cannet, S Zurbruegg, J R Fozard, C P Page and N Beckmann
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.174
Interactions between cell death induced by statins and 7-ketocholesterol in rabbit aorta smooth muscle cells
W Martinet, D M Schrijvers, J-P Timmermans and H Bult
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.181
The cannabinoid receptor-1 antagonist rimonabant inhibits platelet activation and reduces pro-inflammatory chemokines and leukocytes in Zucker rats
A Schäfer, J Pfrang, J Neumüller, S Fiedler, G Ertl and J Bauersachs
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.158
Crocetin improves the insulin resistance induced by high-fat diet in rats
L Sheng, Z Qian, Y Shi, L Yang, L Xi, B Zhao, X Xu and H Ji
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.160
Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats
C R Tirapelli, E Legros, I Brochu, J-C Honoré, V L Lanchote, S A Uyemura, A M de Oliveira and P D'Orléans-Juste
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.157
Endothelial nitric oxide attenuates Na+/Ca2+ exchanger-mediated vasoconstriction in rat aorta
J Zhao and H Majewski
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.178
The 
-opioid receptor agonist morphine, but not agonists at 
- or 
-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors
D da Fonseca Pacheco, A Klein, A de Castro Perez, C M da Fonseca Pacheco, J N de Francischi and I D G Duarte
Br J Pharmacol advance online publication, May 12, 2008; doi:10.1038/bjp.2008.175
May 5 2008
Commentary
Rimonabant in rats with a metabolic syndrome: good news after the depression FREE
V Di Marzo and A Szallasi
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.170
Reviews
DNAzymes and cardiovascular disease
V L Benson, L M Khachigian and H C Lowe
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.145
Negative regulation of multifunctional Ca2+/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases
A Ishida, N Sueyoshi, Y Shigeri and I Kameshita
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.127
Research Papers
Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice
R Costa, D M Marotta, M N Manjavachi, E S Fernandes, J F Lima-Garcia, A F Paszcuk, N L M Quintão, L Juliano, S D Brain and J B Calixto
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.172
Rapamycin affects early fracture healing in mice
J H Holstein, M Klein, P Garcia, T Histing, U Culemann, A Pizanis, M W Laschke, C Scheuer, C Meier, H Schorr, T Pohlemann and M D Menger
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.167
Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1
C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu and J Watson
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.152
Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells
Y G Lee, W M Lee, J Y Kim, J Y Lee, I-K Lee, B-S Yun, M H Rhee and J Y Cho
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.136
Hydrogen peroxide-induced translocation of glycolipid-anchored (c)AMP-hydrolases to lipid droplets mediates inhibition of lipolysis in rat adipocytes
G Müller, S Wied, C Jung and S Over
Br J Pharmacol advance online publication, May 5, 2008; doi:10.1038/bjp.2008.146
April 28 2008
Commentary
Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function FREE
C R Triggle
Br J Pharmacol advance online publication, April 28, 2008; doi:10.1038/bjp.2008.168
April 21 2008
Reviews
Future innovations in anti-platelet therapies
N E Barrett, L Holbrook, S Jones, W J Kaiser, L A Moraes, R Rana, T Sage, R G Stanley, K L Tucker, B Wright and J M Gibbins
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.151
The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships
A A Fossa
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.123
Indirect androgen doping by oestrogen blockade in sports
D J Handelsman
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.150
Gene doping: the hype and the reality
D J Wells
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.144
Research Papers
A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin
V Cano, B Merino, L Ezquerra, B Somoza and M Ruiz-Gayo
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.149
Translocation of the insulin-regulated aminopeptidase to the cell surface: detection by radioligand binding
H Demaegdt, L Smitz, J-P De Backer, M T Le, M Bauwens, E Szemenyei, G Tóth, Y Michotte, P Vanderheyden and G Vauquelin
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.117
Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model
A Farkas, J Dempster and S J Coker
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.154
Effect of chondroitin sulphate in a rabbit model of atherosclerosis aggravated by chronic arthritis
G Herrero-Beaumont, M E Marcos, O Sánchez-Pernaute, R Granados, L Ortega, E Montell, J Vergés, J Egido and R Largo
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.113
Anti-inflammatory effects of phytosteryl ferulates in colitis induced by dextran sulphate sodium in mice
M S Islam, T Murata, M Fujisawa, R Nagasaka, H Ushio, A M Bari, M Hori and H Ozaki
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.137
Heparin and structurally related polymers attenuate eotaxin-1 (CCL11) release from human airway smooth muscle
V Kanabar, C P Page, D E Simcock, C Karner, K Mahn, B J O'Connor and S J Hirst
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.109
Urocortin ameliorates diabetic nephropathy in obese db/db mice
X Li, J Hu, R Zhang, X Sun, Q Zhang, X Guan, J Chen, Q Zhu and S Li
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.155
Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes BJPOpen
Y Liang, D F Woodward, V M Guzman, C Li, D F Scott, J W Wang, L A Wheeler, M E Garst, K Landsverk, G Sachs, A H-P Krauss, C Cornell, J Martos, S Pettit and H Fliri
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.142
Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors
P Malherbe, R Masciadri, R D Norcross, F Knoflach, C Kratzeisen, M-T Zenner, Y Kolb, A Marcuz, J Huwyler, T Nakagawa, R H P Porter, A W Thomas, J G Wettstein, A J Sleight, W Spooren and E P Prinssen
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.135
Effects of MiRP1 and DPP6 
-subunits on the blockade induced by flecainide of KV4.3/KChIP2 channels
S Radicke, M Vaquero, R Caballero, R Gómez, L Núñez, J Tamargo, U Ravens, E Wettwer and E Delpón
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.134
Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17
P Requena, A Daddaoua, E Martínez-Plata, M González, A Zarzuelo, M D Suárez, F Sánchez de Medina and O Martínez-Augustin
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.138
Regulation of M2-type pyruvate kinase mediated by the high-affinity IgE receptors is required for mast cell degranulation
H Ryu, J K L Walker, S Kim, N Koo, L S Barak, T Noguchi, B Y Kang and K-M Kim
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.148
Sites of action of hydrogen peroxide on ion transport across rat distal colon
G Schultheiss, B Hennig and M Diener
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.162
Lapaquistat acetate, a squalene synthase inhibitor, changes macrophage/lipid-rich coronary plaques of hypercholesterolaemic rabbits into fibrous lesions
M Shiomi, S Yamada, Y Amano, T Nishimoto and T Ito
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.143
Pattern recognition receptors and interleukin-8 mediate effects of Gram-positive and Gram-negative bacteria on lung epithelial cell function
R Sorrentino, P M de Souza, S Sriskandan, C Duffin, M J Paul-Clark and J A Mitchell
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.139
Arsenic trioxide and auranofin inhibit selenoprotein synthesis: implications for chemotherapy for acute promyelocytic leukaemia
S Talbot, R Nelson and W T Self
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.161
Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets
H A Toque, C E Teixeira, F B M Priviero, R P Morganti, E Antunes and G De Nucci
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.141
Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the Gq/11 protein
F Yasui, M Miyazu, A Yoshida, K Naruse and A Takai
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.140
Anticonvulsant effect of BmK IT2, a sodium channel-specific neurotoxin, in rat models of epilepsy
R Zhao, X-Y Zhang, J Yang, C-C Weng, L-L Jiang, J-W Zhang, X-Q Shu and Y-H Ji
Br J Pharmacol advance online publication, April 21, 2008; doi:10.1038/bjp.2008.156
April 14 2008
Commentary
Diabetic cardiomyopathy: how much does it depend on AGE? FREE
M Montagnani
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.121
Reviews
Cellular and molecular mechanisms responsible for the action of testosterone on human skeletal muscle. A basis for illegal performance enhancement
F Kadi
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.118
Gonadotropins in doping: pharmacological basis and detection of illicit use
U-H Stenman, K Hotakainen and H Alfthan
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.102
Research Papers
Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures
K Albus, A Wahab and U Heinemann
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.112
Regression of aortic valve stenosis by ApoA-I mimetic peptide infusions in rabbits BJPOpen
D Busseuil, Y Shi, M Mecteau, G Brand, A-E Kernaleguen, E Thorin, J-G Latour, E Rhéaume and J-C Tardif
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.122
Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice
A Drouin, M-È Gendron, E Thorin, M-A Gillis, F Mahlberg-Gaudin and J-C Tardif
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.116
Novel consequences of voltage-dependence to G-protein-coupled P2Y1 receptors
I S Gurung, J Martinez-Pinna and M P Mahaut-Smith
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.97
AM3, a natural glycoconjugate, induces the functional maturation of human dendritic cells BJPOpen
S Martín-Vilchez, F Molina-Jiménez, J L Alonso-Lebrero, P Sanz-Cameno, Y Rodríguez-Muñoz, I Benedicto, P Roda-Navarro, M Trapero, L Aragoneses-Fenoll, S González, J P Pivel, A L Corbí, M López-Cabrera, R Moreno-Otero and P L Majano
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.87
The existence of a local 5-hydroxytryptaminergic system in peripheral arteries
W Ni, T J Geddes, J R C Priestley, T Szasz, D M Kuhn and S W Watts
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.111
Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats
Y Shi and P M Vanhoutte
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.110
Aldosterone and the autocrine modulation of potassium currents and oxidative stress in the diabetic rat heart
Y Shimoni, K Chen, T Emmett and G Kargacin
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.114
Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk
V Sibilia, F Pagani, G Rindi, N Lattuada, D Rapetti, V De Luca, N Campanini, I Bulgarelli, V Locatelli, F Guidobono and C Netti
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.120
The expression and function of Ca2+-sensing receptors in rat mesenteric artery; comparative studies using a model of type II diabetes
A H Weston, M Absi, E Harno, A R Geraghty, D T Ward, M Ruat, R H Dodd, P Dauban and G Edwards
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.108
Bone morphogenetic protein signalling is required for the anti-mitogenic effect of the proteasome inhibitor MG-132 on colon cancer cells
W K K Wu, J J Y Sung, Y C Wu, Z J Li, L Yu and C H Cho
Br J Pharmacol advance online publication, April 14, 2008; doi:10.1038/bjp.2008.115
March 31 2008
Review
Growth hormone, IGF-I and insulin and their abuse in sport
R I G Holt and P H Sönksen
Br J Pharmacol advance online publication, March 31, 2008; doi:10.1038/bjp.2008.99
Research Paper
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes
M-S Wu, J-T Liang, Y-D Lin, E-T Wu, Y-Z Tseng and K-C Chang
Br J Pharmacol advance online publication, March 31, 2008; doi:10.1038/bjp.2008.119
