Photodynamic therapy: novel third-generation photosensitizers one step closer? FREE

L B Josefsen and R W Boyle

Br J Pharmacol 154: 1-3; advance online publication, March 24, 2008; doi:10.1038/bjp.2008.98

Abstract | Full Text | PDF

Photodynamic activity of BAM-SiPc, an unsymmetrical bisamino silicon(IV) phthalocyanine, in tumour-bearing nude mice

S C H Leung, P-C Lo, D K P Ng, W-K Liu, K-P Fung and W-P Fong

Br J Pharmacol 154: 4-12; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.82

Abstract | Full Text | PDF

Endothelin (ET)-1 and ET-3 promote expression of c-fos and c-jun in human choriocarcinoma via ET_B receptor-mediated G_i- and G_q-pathways and MAP kinase activation

A Rauh, W Windischhofer, A Kovacevic, T DeVaney, E Huber, M Semlitsch, H-J Leis, W Sattler and E Malle

Br J Pharmacol 154: 13-24; advance online publication, March 24, 2008; doi:10.1038/bjp.2008.92

Abstract | Full Text | PDF

Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG

O Maas, U Donat, M Frenzel, T Rütz, H K Kroemer, S B Felix and T Krieg

Br J Pharmacol 154: 25-31; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.71

Abstract | Full Text | PDF

Endothelium removal augments endothelium-independent vasodilatation in rat mesenteric vascular bed

Y Iwatani, K Kosugi, S Isobe-Oku, S Atagi, Y Kitamura and H Kawasaki

Br J Pharmacol 154: 32-40; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.72

Abstract | Full Text | PDF

A role for the RISK pathway and K_ATP channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart

E F du Toit, A Genis, L H Opie, P Pollesello and A Lochner

Br J Pharmacol 154: 41-50; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.52

Abstract | Full Text | PDF

Pharmacological profile of the clonidine-induced inhibition of vasodepressor sensory outflow in pithed rats: correlation with _2A/2C-adrenoceptors

C M Villalón, J A Albarrán-Juárez, J Lozano-Cuenca, H H Pertz, T Görnemann and D Centurión

Br J Pharmacol 154: 51-59; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.49

Abstract | Full Text | PDF

Autonomic nervous system-dependent and -independent cardiovascular effects of exendin-4 infusion in conscious rats

S M Gardiner, J E March, P A Kemp and T Bennett

Br J Pharmacol 154: 60-71; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.75

Abstract | Full Text | PDF

K_ATP channel expression and pharmacological in vivo and in vitro studies of the K_ATP channel blocker PNU-37883A in rat middle meningeal arteries

K B Ploug, L J Boni, M Baun, A Hay-Schmidt, J Olesen and I Jansen-Olesen

Br J Pharmacol 154: 72-81; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.86

Abstract | Full Text | PDF

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca²⁺ responses in endothelial cells

M Campos-Toimil, T Keravis, F Orallo, K Takeda and C Lugnier

Br J Pharmacol 154: 82-92; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.56

Abstract | Full Text | PDF

Na⁺/Ca²⁺ exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart

A S Farkas, K Acsai, N Nagy, A Tóth, F Fülöp, G Seprényi, P Birinyi, P P Nánási, T Forster, M Csanády, J G Papp, A Varró and A Farkas

Br J Pharmacol 154: 93-104; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.83

Abstract | Full Text | PDF

Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo

X-Y Zhao, G-Y Li, Y Liu, L-M Chai, J-X Chen, Y Zhang, Z-M Du, Y-J Lu and B-F Yang

Br J Pharmacol 154: 105-113; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.81

Abstract | Full Text | PDF

Rapid degradation of hypoxia-inducible factor-1 by KRH102053, a new activator of prolyl hydroxylase 2

H J Choi, B-J Song, Y-D Gong, W J Gwak and Y Soh

Br J Pharmacol 154: 114-125; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.70

Abstract | Full Text | PDF

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon

A K Bassil, R A Borman, E M Jarvie, R J McArthur-Wilson, R Thangiah, E Z H Sung, K Lee and G J Sanger

Br J Pharmacol 154: 126-135; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.84

Abstract | Full Text | PDF

Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors

M Abdouh, S Talbot, R Couture and H M Hasséssian

Br J Pharmacol 154: 136-143; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.48

Abstract | Full Text | PDF

A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor- protein expression in human monocytes and macrophages

A Amoruso, C Bardelli, G Gunella, F Ribichini and S Brunelleschi

Br J Pharmacol 154: 144-152; advance online publication, February 18, 2008; doi:10.1038/bjp.2008.50

Abstract | Full Text | PDF

A potent and selective p38 inhibitor protects against bone damage in murine collagen-induced arthritis: a comparison with neutralization of mouse TNF

K Mihara, C Almansa, R L Smeets, E E M G Loomans, J Dulos, P M F Vink, M Rooseboom, H Kreutzer, F Cavalcanti, A M Boots and R L Nelissen

Br J Pharmacol 154: 153-164; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.53

Abstract | Full Text | PDF

Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-B-dependent iNOS and proinflammatory cytokines production

Y W Kim, R J Zhao, S J Park, J R Lee, I J Cho, C H Yang, S G Kim and S C Kim

Br J Pharmacol 154: 165-173; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.79

Abstract | Full Text | PDF

Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT_1A receptors

B Manéglier, G J Guillemin, P Clayette, C Rogez-Kreuz, B J Brew, D Dormont, C Advenier, P Therond and O Spreux-Varoquaux

Br J Pharmacol 154: 174-182; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.80

Abstract | Full Text | PDF

Acetazolamide prevents vacuolar myopathy in skeletal muscle of K⁺-depleted rats

D Tricarico, S Lovaglio, A Mele, G Rotondo, E Mancinelli, G Meola and D C Camerino

Br J Pharmacol 154: 183-190; advance online publication, March 17, 2008; doi:10.1038/bjp.2008.42

Abstract | Full Text | PDF

Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons

B Li, T Du, H Li, L Gu, H Zhang, J Huang, L Hertz and L Peng

Br J Pharmacol 154: 191-203; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.58

Abstract | Full Text | PDF

The phytocannabinoid ⁹-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum

Y-L Ma, S E Weston, B J Whalley and G J Stephens

Br J Pharmacol 154: 204-215; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.57

Abstract | Full Text | PDF

Gabapentin activates ROMK1 channels by a protein kinase A (PKA)-dependent mechanism

C-H Lee, T-S Tsai and H-H Liou

Br J Pharmacol 154: 216-225; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.73

Abstract | Full Text | PDF

The PPAR agonist pioglitazone is effective in the MPTP mouse model of Parkinson's disease through inhibition of monoamine oxidase B

L P Quinn, B Crook, M E Hows, M Vidgeon-Hart, H Chapman, N Upton, A D Medhurst and D J Virley

Br J Pharmacol 154: 226-233; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.78

Abstract | Full Text | PDF

Flurazepam effect on GABAergic currents depends on extracellular pH ^BJPOpen

T Wójtowicz, P Wyrembek, K Lebida, M Piast and J W Mozrzymas

Br J Pharmacol 154: 234-245; advance online publication, March 24, 2008; doi:10.1038/bjp.2008.90

Abstract | Full Text | PDF

Na⁺/Ca²⁺ exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart FREE

A S Farkas, K Acsai, N Nagy, A Tóth, F Fülöp, G Seprényi, P Birinyi, P P Nánási, T Forster, M Csanády, J G Papp, A Varró and A Farkas

Br J Pharmacol 154: 256-257; doi:10.1038/bjp.2008.128

Abstract | Full Text | PDF