TABLE OF CONTENTS

Volume 153, Issue 8 (April 2008)

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Commentary

Commentary

Lipoic acid supplementation and endothelial function FREE

J-C Tardif and E Rhéaume

Br J Pharmacol 153: 1587-1588; advance online publication, March 17, 2008; doi:10.1038/bjp.2008.74

See also: Research Paper by Smith et al.
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Reviews

Review Article

Heart rate in the pathophysiology of coronary blood flow and myocardial ischaemia: benefit from selective bradycardic agents

G Heusch

Br J Pharmacol 153: 1589-1601; advance online publication, January 28, 2008; doi:10.1038/sj.bjp.0707673

Asthma from a pharmacogenomic point of view

C Szalai, I Ungvári, L Pelyhe, G Tölgyesi and A Falus

Br J Pharmacol 153: 1602-1614; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.55

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Research Papers

Cardiovascular and pulmonary pharmacology

Lipoic acid significantly restores, in rats, the age-related decline in vasomotion

A R Smith, F Visioli, B Frei and T M Hagen

Br J Pharmacol 153: 1615-1622; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.28

See also: Commentary by Tardif & Rhéaume
The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways

M Iwasaki, Y Hayashi, T Kamibayashi, A Yamatodani and T Mashimo

Br J Pharmacol 153: 1623-1630; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.35

Indomethacin promotes nitric oxide function in the ductus arteriosus in the mouse

D Sodini, B Baragatti, S Barogi, V E Laubach and F Coceani

Br J Pharmacol 153: 1631-1640; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.36

Dose-dependent protective effect of propofol against mitochondrial dysfunction in ischaemic/reperfused rat heart: role of cardiolipin

H Shao, J Li, Y Zhou, Z Ge, J Fan, Z Shao and Y Zeng

Br J Pharmacol 153: 1641-1649; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.45

Gastrointestinal pharmacology

Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction

T D Barrett, W Yan, J M Freedman, G J Lagaud, J G Breitenbucher and N P Shankley

Br J Pharmacol 153: 1650-1658; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.44

Genitourinary, renal and endocrine pharmacology

Long-term nitric oxide deficiency causes muscarinic supersensitivity and reduces beta3-adrenoceptor-mediated relaxation, causing rat detrusor overactivity

F Z T Mónica, A A O Bricola, F R Báu, L L Lopes Freitas, S A Teixeira, M N Muscará, F M F Abdalla, C S Porto, G De Nucci, A Zanesco and E Antunes

Br J Pharmacol 153: 1659-1668; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.39

Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice

M H Mooney, S Fogarty, C Stevenson, A M Gallagher, P Palit, S A Hawley, D G Hardie, G D Coxon, R D Waigh, R J Tate, A L Harvey and B L Furman

Br J Pharmacol 153: 1669-1677; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.37

Immunopharmacology and inflammation

Sodium/hydrogen exchange inhibition with cariporide reduces leukocyte adhesion via P-selectin suppression during inflammation

U Buerke, D Pruefer, J M Carter, M Russ, A Schlitt, R Prondzinsky, J Makowski, S Rohrbach, B Niemann, C Schulze, M Dahm, C-F Vahl, K Werdan and M Buerke

Br J Pharmacol 153: 1678-1685; advance online publication, March 10, 2008; doi:10.1038/sj.bjp.0707647

Molecular and cellular mechanisms

Antimalarial drugs inhibit human 5-HT3 and GABAA but not GABAC receptors BJPOpen

A J Thompson and S C R Lummis

Br J Pharmacol 153: 1686-1696; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.34

9-Phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels

T Grand, M Demion, C Norez, Y Mettey, P Launay, F Becq, P Bois and R Guinamard

Br J Pharmacol 153: 1697-1705; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.38

A nitric oxide/Ca2+/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells

A Meini, C Sticozzi, L Massai and M Palmi

Br J Pharmacol 153: 1706-1717; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.40

Structural requirements for the cytoprotective actions of mono-unsaturated fatty acids in the pancreatic beta-cell line, BRIN-BD11

S Dhayal, H J Welters and N G Morgan

Br J Pharmacol 153: 1718-1727; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.43

Neuropharmacology

Cardiovascular effects of activation of central alpha7 and alpha4beta2 nAChRs: a role for vasopressin in anaesthetized rats

C Moore, Y Wang and A G Ramage

Br J Pharmacol 153: 1728-1738; advance online publication, February 25, 2008; doi:10.1038/bjp.2008.47

Thymol and related alkyl phenols activate the hTRPA1 channel

S P Lee, M T Buber, Q Yang, R Cerne, R Y Cortés, D G Sprous and R W Bryant

Br J Pharmacol 153: 1739-1749; advance online publication, March 10, 2008; doi:10.1038/bjp.2008.85

Pharmacokinetics, drug metabolism, toxicology

Influence of the metabolic profile on the in vivo antioxidant activity of quercetin under a low dosage oral regimen in rats

M R Santos, M J Rodríguez-Gómez, G C Justino, N Charro, M H Florencio and L Mira

Br J Pharmacol 153: 1750-1761; advance online publication, March 3, 2008; doi:10.1038/bjp.2008.46

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Corrigenda

Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats FREE

D R H Huntjens, A Strougo, A Chain, A Metcalf, S Summerfield, D J M Spalding, M Danhof and O Della Pasqua

Br J Pharmacol 153: 1762; doi:10.1038/bjp.2008.105

Antagonism of thromboxane receptors by diclofenac and lumiracoxib FREE

E Selg, C Buccellati, M Andersson, G E Rovati, M Ezinga, A Sala, A-K Larsson, E Ambrosio, L Låstbom, V Capra, B Dahlén, Å Ryrfeldt, G C Folco and S-E Dahlén

Br J Pharmacol 153: 1763; doi:10.1038/bjp.2008.106

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Errata

Sildenafil reduces the alcohol-induced gastric damage: just say 'NO' FREE

R Duffin, C A Shaw and A G Rossi

Br J Pharmacol 153: 1764; doi:10.1038/bjp.2008.103

Deciphering the beta-adrenergic response in human embryonic stem cell-derived-cardiac myocytes: closer to clinical use? FREE

D Catalucci, M L Bang and G Condorelli

Br J Pharmacol 153: 1765; doi:10.1038/bjp.2008.104

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