TABLE OF CONTENTS

Volume 153, Issue 6 (March 2008)

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Commentaries

Commentary

Combining inhaled glucocorticoids and long acting beta2-adrenoceptor agonists in asthma and COPD FREE

A J Knox and K Mortimer

Br J Pharmacol 153: 1085-1086; advance online publication, January 28, 2008; doi:10.1038/bjp.2008.4

See also: Review by Giembycz et al.
cAMP: fuel for extracellular adenosine formation? FREE

A Gödecke

Br J Pharmacol 153: 1087-1089; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.7

See also: Research Paper by Chiavegatti et al.
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Reviews

Review Article

A Holy Grail of asthma management: toward understanding how long-acting beta2-adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids FREE

M A Giembycz, M Kaur, R Leigh and R Newton

Br J Pharmacol 153: 1090-1104; advance online publication, December 10, 2007; doi:10.1038/sj.bjp.0707627

See also: Commentary by Knox & Mortimer
The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house? FREE

N S Kirkby, P W F Hadoke, A J Bagnall and D J Webb

Br J Pharmacol 153: 1105-1119; advance online publication, October 29, 2007; doi:10.1038/sj.bjp.0707516

Pharmacokinetics, efficacy, and safety of LMWHs in venous thrombosis and stroke in neonates, infants and children FREE

U Nowak-Göttl, C Bidlingmaier, A Krümpel, L Göttl and G Kenet

Br J Pharmacol 153: 1120-1127; advance online publication, October 1, 2007; doi:10.1038/sj.bjp.0707447

Frontiers in pharmacology

Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium FREE

J C Shryock and L Belardinelli

Br J Pharmacol 153: 1128-1132; advance online publication, December 10, 2007; doi:10.1038/sj.bjp.0707522

The cardiac persistent sodium current: an appealing therapeutic target? FREE

D A Saint

Br J Pharmacol 153: 1133-1142; advance online publication, December 10, 2007; doi:10.1038/sj.bjp.0707492

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Research Papers

Biopharmaceuticals

Comparative study on transduction and toxicity of protein transduction domains

T Sugita, T Yoshikawa, Y Mukai, N Yamanada, S Imai, K Nagano, Y Yoshida, H Shibata, Y Yoshioka, S Nakagawa, H Kamada, S-i Tsunoda and Y Tsutsumi

Br J Pharmacol 153: 1143-1152; advance online publication, January 28, 2008; doi:10.1038/sj.bjp.0707678

Cancer Pharmacology

Celecoxib modulates adhesion of HT29 colon cancer cells to vascular endothelial cells by inhibiting ICAM-1 and VCAM-1 expression

C Dianzani, L Brucato, M Gallicchio, A C Rosa, M Collino and R Fantozzi

Br J Pharmacol 153: 1153-1161; advance online publication, December 17, 2007; doi:10.1038/sj.bjp.0707636

Cardiovascular and pulmonary pharmacology

Flow-induced enhancement of vasoconstriction and blockade of endothelium-derived hyperpolarizing factor (EDHF) by ascorbate in the rat mesentery BJPOpen

A Stirrat, S Nelli, F J Dowell and W Martin

Br J Pharmacol 153: 1162-1168; advance online publication, October 8, 2007; doi:10.1038/sj.bjp.0707499

Dipyridamole enhances ischaemia-induced reactive hyperaemia by increased adenosine receptor stimulation

P Meijer, C W Wouters, P H H van den Broek, G J Scheffer, N P Riksen, P Smits and G A Rongen

Br J Pharmacol 153: 1169-1176; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.10

Enhanced antithrombotic effects of unfractionated heparin in rats after repeated oral doses and its relationship to endothelial heparin concentration

L M Hiebert, T Ping and S M Wice

Br J Pharmacol 153: 1177-1184; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.14

ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries

U Simonsen, B E Laursen and J S Petersen

Br J Pharmacol 153: 1185-1194; advance online publication, January 14, 2008; doi:10.1038/sj.bjp.0707688

Gastrointestinal pharmacology

The role of GABAA receptors in the control of transient lower oesophageal sphincter relaxations in the dog

H Beaumont, A-C Jönsson-Rylander, K Carlsson, S Pierrou, M Ahlefelt, L Brändén, J Jensen, G E Boeckxstaens and A Lehmann

Br J Pharmacol 153: 1195-1202; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707681

Palmatine, a protoberberine alkaloid, inhibits both Ca2+- and cAMP-activated Cl- secretion in isolated rat distal colon

D Z Wu, J Y Yuan, H L Shi and Z B Hu

Br J Pharmacol 153: 1203-1213; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707684

Contractile agonists attenuate cGMP levels by stimulating phosphorylation of cGMP-specific PDE5; an effect mediated by RhoA/PKC-dependent inhibition of protein phosphatase 1

K S Murthy

Br J Pharmacol 153: 1214-1224; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707686

Genitourinary, renal and endocrine pharmacology

Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy

K Tikoo, R L Meena, D G Kabra and A B Gaikwad

Br J Pharmacol 153: 1225-1231; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707666

Influence of combined hypertension and renal failure on functional alpha1-adrenoceptor subtypes in the rat kidney

M A Hye Khan, M A Sattar, N A Abdullah and E J Johns

Br J Pharmacol 153: 1232-1241; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.13

Evidence for the participation of calcium in non-genomic relaxations induced by androgenic steroids in rat vas deferens

S S L Lafayette, I Vladimirova, L Garcez-do-Carmo, P T Monteforte, A Caricati Neto and A Jurkiewicz

Br J Pharmacol 153: 1242-1250; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.18

Role of neuronal voltage-gated K+ channels in the modulation of the nitrergic neurotransmission of the pig urinary bladder neck

M Hernández, M V Barahona, P Recio, J Navarro-Dorado, S Bustamante, S Benedito, A García-Sacristán, D Prieto and L M Orensanz

Br J Pharmacol 153: 1251-1258; advance online publication, January 28, 2008; doi:10.1038/sj.bjp.0707669

Methionine and its derivatives increase bladder excitability by inhibiting stretch-dependent K+ channels

S A Baker, G W Hennig, J Han, F C Britton, T K Smith and S D Koh

Br J Pharmacol 153: 1259-1271; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707690

The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet

V Di Marzo, R Capasso, I Matias, G Aviello, S Petrosino, F Borrelli, B Romano, P Orlando, F Capasso and A A Izzo

Br J Pharmacol 153: 1272-1280; advance online publication, January 28, 2008; doi:10.1038/sj.bjp.0707682

Immunopharmacology and inflammation

Enhanced nitric oxide and cyclic GMP formation plays a role in the anti-platelet activity of simvastatin

T-C Chou, Y-F Lin, W-C Wu and K-M Chu

Br J Pharmacol 153: 1281-1287; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.19

Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: a rationale for use of low-dose colchicine

E W Chia, R Grainger and J L Harper

Br J Pharmacol 153: 1288-1295; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.20

Involvement of tumour necrosis factor-alpha in Clostridium perfringens beta-toxin-induced plasma extravasation in mice

M Nagahama, A Kihara, H Kintoh, M Oda and J Sakurai

Br J Pharmacol 153: 1296-1302; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.9

The new water-soluble artemisinin derivative SM905 ameliorates collagen-induced arthritis by suppression of inflammatory and Th17 responses

J-X Wang, W Tang, R Zhou, J Wan, L-P Shi, Y Zhang, Y-F Yang, Y Li and J-P Zuo

Br J Pharmacol 153: 1303-1310; advance online publication, February 11, 2008; doi:10.1038/bjp.2008.11

Molecular and cellular mechanisms

Prolonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator

A Schmidt, L K Hughes, Z Cai, F Mendes, H Li, D N Sheppard and M D Amaral

Br J Pharmacol 153: 1311-1323; advance online publication, January 28, 2008; doi:10.1038/sj.bjp.0707663

Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB)

K Togashi, H Inada and M Tominaga

Br J Pharmacol 153: 1324-1330; advance online publication, January 21, 2008; doi:10.1038/sj.bjp.0707675

Skeletal muscle expresses the extracellular cyclic AMP–adenosine pathway

T Chiavegatti, V L Costa Jr, M S Araújo and R O Godinho

Br J Pharmacol 153: 1331-1340; advance online publication, December 24, 2007; doi:10.1038/sj.bjp.0707648

See also: Commentary by Gödecke

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