TABLE OF CONTENTS

Themed issue: CB2 Receptors

This issue has been edited by Ruth Ross and Ken Mackie and contains 16 review articles and 5 original articles which seek to give further insight into the function and role of the hitherto enigmatic CB2 receptor. The meeting "CB2 cannabinoid receptors: New vistas" was held in Banff, Canada in 2007 and was organized by Keith Sharkey, Ken Mackie, Betty Yao, Marnie Duncan and Ruth Ross. This meeting was designed to bring together scientists studying CB2 receptors from diverse perspectives, including those interested in the chemistry of CB2 ligands, the role of CB2 receptors in normal biological processes, and the involvement of CB2 receptors in pathological processes.


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Commentary

Good news for CB1 receptors: endogenous agonists are in the right place FREE

M Maccarrone

Br J Pharmacol 153: 179-181; advance online publication, November 12, 2007; doi:10.1038/sj.bjp.0707566

See also: Research Paper by Rimmerman et al.

Review Article

Cannabinoid receptors and the regulation of bone mass FREE

I Bab and A Zimmer

Br J Pharmacol 153: 182-188; advance online publication, December 10, 2007; doi:10.1038/sj.bjp.0707593

See also: Commentary by Mackie & Ross
CB2 receptors in reproduction FREE

M Maccarrone

Br J Pharmacol 153: 189-198; advance online publication, September 10, 2007; doi:10.1038/sj.bjp.0707444

See also: Commentary by Mackie & Ross
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and Delta9-tetrahydrocannabivarin FREE

R G Pertwee

Br J Pharmacol 153: 199-215; advance online publication, September 10, 2007; doi:10.1038/sj.bjp.0707442

See also: Commentary by Mackie & Ross
CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies FREE

Á Arévalo-Martín, D García-Ovejero, O Gómez, A Rubio-Araiz, B Navarro-Galve, C Guaza, E Molina-Holgado and F Molina-Holgado

Br J Pharmacol 153: 216-225; advance online publication, September 24, 2007; doi:10.1038/sj.bjp.0707466

See also: Commentary by Mackie & Ross
Biology and therapeutic potential of cannabinoid CB2 receptor inverse agonists

C A Lunn, E-P Reich, J S Fine, B Lavey, J A Kozlowski, R W Hipkin, D J Lundell and L Bober

Br J Pharmacol 153: 226-239; advance online publication, October 1, 2007; doi:10.1038/sj.bjp.0707480

See also: Commentary by Mackie & Ross
CB2 receptors in the brain: role in central immune function FREE

G A Cabral, E S Raborn, L Griffin, J Dennis and F Marciano-Cabral

Br J Pharmacol 153: 240-251; advance online publication, November 26, 2007; doi:10.1038/sj.bjp.0707584

See also: Commentary by Mackie & Ross
Endocannabinoids and cannabinoid receptors in ischaemia–reperfusion injury and preconditioning FREE

P Pacher and G Haskó

Br J Pharmacol 153: 252-262; advance online publication, November 19, 2007; doi:10.1038/sj.bjp.0707582

See also: Commentary by Mackie & Ross
Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation FREE

K L Wright, M Duncan and K A Sharkey

Br J Pharmacol 153: 263-270; advance online publication, October 1, 2007; doi:10.1038/sj.bjp.0707486

See also: Commentary by Mackie & Ross
Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor FREE

B N Dittel

Br J Pharmacol 153: 271-276; advance online publication, October 8, 2007; doi:10.1038/sj.bjp.0707493

See also: Commentary by Mackie & Ross
Cannabinoid CB2 receptors in human brain inflammation FREE

C Benito, R M Tolón, M R Pazos, E Núñez, A I Castillo and J Romero

Br J Pharmacol 153: 277-285; advance online publication, October 15, 2007; doi:10.1038/sj.bjp.0707505

See also: Commentary by Mackie & Ross
CB2 receptors as new therapeutic targets for liver diseases FREE

S Lotersztajn, F Teixeira-Clerc, B Julien, V Deveaux, Y Ichigotani, S Manin, J Tran-Van-Nhieu, M Karsak, A Zimmer and A Mallat

Br J Pharmacol 153: 286-289; advance online publication, October 22, 2007; doi:10.1038/sj.bjp.0707511

See also: Commentary by Mackie & Ross
Cannabinoid receptors in acute and chronic complications of atherosclerosis FREE

F Mach, F Montecucco and S Steffens

Br J Pharmacol 153: 290-298; advance online publication, October 29, 2007; doi:10.1038/sj.bjp.0707517

See also: Commentary by Mackie & Ross
CB2 receptor-mediated migration of immune cells: it can go either way FREE

A M Miller and N Stella

Br J Pharmacol 153: 299-308; advance online publication, November 5, 2007; doi:10.1038/sj.bjp.0707523

See also: Commentary by Mackie & Ross
The peripheral cannabinoid receptor knockout mice: an update FREE

N E Buckley

Br J Pharmacol 153: 309-318; advance online publication, October 29, 2007; doi:10.1038/sj.bjp.0707527

See also: Commentary by Mackie & Ross
Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain FREE

J Guindon and A G Hohmann

Br J Pharmacol 153: 319-334; advance online publication, November 12, 2007; doi:10.1038/sj.bjp.0707531

See also: Commentary by Mackie & Ross
Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands FREE

A Poso and J W Huffman

Br J Pharmacol 153: 335-346; advance online publication, November 5, 2007; doi:10.1038/sj.bjp.0707567

See also: Commentary by Mackie & Ross

Neuropharmacology

Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI

C-L Chin, A E Tovcimak, V P Hradil, T R Seifert, P R Hollingsworth, P Chandran, C Z Zhu, D Gauvin, M Pai, J Wetter, G C Hsieh, P Honore, J M Frost, M J Dart, M D Meyer, B B Yao, B F Cox and G B Fox

Br J Pharmacol 153: 367-379; advance online publication, October 29, 2007; doi:10.1038/sj.bjp.0707506

See also: Commentary by Mackie & Ross
Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line

N Rimmerman, H V Hughes, H B Bradshaw, M X Pazos, K Mackie, A L Prieto and J M Walker

Br J Pharmacol 153: 380-389; advance online publication, October 29, 2007; doi:10.1038/sj.bjp.0707561

See also: Commentary by MaccarroneSee also: Commentary by Mackie & Ross
In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models

B B Yao, G C Hsieh, J M Frost, Y Fan, T R Garrison, A V Daza, G K Grayson, C Z Zhu, M Pai, P Chandran, A K Salyers, E J Wensink, P Honore, J P Sullivan, M J Dart and M D Meyer

Br J Pharmacol 153: 390-401; advance online publication, November 12, 2007; doi:10.1038/sj.bjp.0707568

See also: Commentary by Mackie & Ross

Cardiovascular and pulmonary pharmacology

CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration

M Rajesh, P Mukhopadhyay, G Haskó, J W Huffman, K Mackie and P Pacher

Br J Pharmacol 153: 347-357; advance online publication, November 12, 2007; doi:10.1038/sj.bjp.0707569

See also: Commentary by Mackie & Ross

Immunopharmacology and inflammation

In vivo effects of CB2 receptor-selective cannabinoids on the vasculature of normal and arthritic rat knee joints

J J McDougall, V Yu and J Thomson

Br J Pharmacol 153: 358-366; advance online publication, November 5, 2007; doi:10.1038/sj.bjp.0707565

See also: Commentary by Mackie & Ross

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