FIGURE 1

Endocannabinoid-like molecules (ECLs). In these structures, R1 is the hydrocarbon side chain, for example, C₁₉H₃₁ (generating arachidonyl/arachidonoyl), C₁₇H₃₃ (generating oleyl/oleoyl) and C₁₅H₃₁ (generating palmityl/palmitoyl). ECLs can be primary amides (a: for example, oleamide, ODA); N-acylethanolamides (b: for example, anandamide, AEA; N-oleoylethanolamide, OEA; N-palmitoylethanolamide, PEA); N-acylamino acids (c: for example, N-arachidonoylglycine, NAGly; N-arachidonoylGABA; N-arachidonoylalanine); N-acyldopamines (d: for example, N-arachidonoyldopamine, NADA; N-oleoyldopamine; N-stearoyldopamine; N-palmitoyldopamine), 2-acylglycerols (e: for example, 2-arachidonoylglycerol, 2AG), 2-alkylglycerols (f: for example, noladin ether-2-arachidonoylglyceryl ether) and O-acylethanolamines (g: for example, virodhamine).