British Journal of Pharmacology

TABLE 3

FROM:

Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences

J M McPartland, M Glass and R G Pertwee

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Table 3. Meta-analytic K i values for ligands at human (Hs) and rat (Rn) cannabinoid receptors

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Ligand HsCB1 RnCB1 HsCB2 RnCB2 HsCB1 HsCB2 RnCB1 RnCB2
 Kiplusminuss.e. Kiplusminuss.e. Kiplusminuss.e. Kiplusminuss.e. Kiplusminuss.e. Kiplusminuss.e. Kiplusminuss.e. Kdplusminuss.e.
THC 25.1plusminus5.54 (n=16) 42.6plusminus5.01 (n=18) 35.2plusminus5.86 (n=16)13.0plusminus7.70 (n=3) 25.1plusminus5.54 (n=16) 35.2plusminus5.86 (n=16) 42.6plusminus5.01 (n=18)13.0plusminus7.70 (n=3)
 Difference between species, P=0.010; K i ratio=0.59  No difference between CB1 and CB2, P=0.12; K i ratio=0.71  
         
CBDND2210.5plusminus558.08 (n=6)2860 (n=1)1000 (n=1)ND2860 (n=1)2210.5plusminus558.08 (n=6)1000 (n=1)
CBN525.3plusminus308.1 (n=3)368.0plusminus121.1 (n=8)168.2plusminus32.16 (n=7)ND525.3plusminus308.1 (n=3)168.2plusminus32.16 (n=7)368.0plusminus121.1 (n=8)ND
AEA 239.2plusminus61.77 (n=16) 87.7plusminus11.32 (n=26) 439.5plusminus95.89 (n=22)267.8plusminus67.94 (n=5) 239.2plusminus61.77 (n=16) 439.5plusminus95.89 (n=22) 87.7plusminus11.32 (n=26)267.8plusminus67.94 (n=5)
 No difference between species, P=0.23; K i ratio=2.7  No difference between CB1 and CB2, P=0.06; K i ratio=0.54  
         
2-AG3423.6plusminus3288.24 (n=3)1180.5plusminus538.59 (n=4)1193.8plusminus327.71 (n=9)1900.0plusminus1800.0 (n=2)3423.6plusminus3288.24 (n=3)1193.8plusminus327.71 (n=9)1180.5plusminus538.59 (n=4)1900.0plusminus1800.0 (n=2)
HU210 0.25plusminus0.069 (n=9) 0.34plusminus0.102 (n=7) 0.40plusminus0.095 (n=15)ND 0.25plusminus0.069 (n=9) 0.40plusminus0.095 (n=15) 0.34plusminus0.102 (n=7)ND
 No difference between species, P=0.49; K i ratio=0.74  No difference between CB1 and CB2, P=0.34; K i ratio=0.63  

 Abbreviations: AEA, anandamide; CB1, cannabinoid receptor subtype 1; CB2, cannabinoid receptor subtype 2; CBD, cannabidiol; cannabinol; Hs, Homo sapiens; Rn, Rattus norvegicus; 2-AG, sn-2 arachidonoyl glycerol.

 The results in the table are expressed as K iplusminuss.e. (nM) and the number of studies extracted for determination of pooled means. Means in bold typeface had their numerical validity confirmed by sensitivity analyses. Differences between validated means were tested for statistical significance with Mann–Whitney U-test (Systat; Evanston, IL, USA). ND=no K i data in Supplementary Table 1.

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