FIGURE 6

The permeability response to capsaicin is inhibited by SDZ NKT 343. (a) The effect of the NK₁ antagonist SDZ NKT 343 on venular permeability was plotted against concentration. (b) The effects of SDZ NKT 343 (0.1–100  M) on the permeability response to capsaicin (100  M); ANOVA with Dunnett's multiple comparison test; four vessels, ^** P<0.01, four vessels from four rats. (c) Dose–effect curves produced by coapplication of SDZ NKT 343 (10–1000  M) with capsaicin; four vessels from four rats. (d) Dose–effect curves produced by coapplication of the enantiomer (R,R)-SDZ NKT 343 (0.1 and 1 mM) with capsaicin; each curve mean of four vessels from four rats. All vessel diameters were between 8 and 15 m.