British Journal of Pharmacology

FIGURE 4

FROM:

TRPV1 activation results in disruption of the blood–brain barrier in the rat

De-En Hu, Alexander S Easton and Paul A Fraser

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Figure 4.

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Effect of capsazepine on the capsaicin-induced permeability increase. (a) The effect of the TRPV1 antagonist capsazepine on venular permeability was plotted against concentration; four vessels. (b) The effects of 1–1000 mu M capsazepine (CZP) on the permeability-increasing effect of 100 mu M capsaicin; ANOVA with Dunnett's multiple comparison test; four vessels, ** P<0.01. (c) Dose–effect curves produced by coapplication of capsazepine (1 mu M–1 mM) with capsaicin; each curve mean of four vessels from four rats: vessel diameters were between 8 and 15 mum.

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