FIGURE 3
FROM:
Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
Shuk Yin M Yeung and Iain A Greenwood
BACK TO ARTICLEFigure 3.
Dissection of the gross outward current into two components. (a) Concentration–response plot to XE991 at +20 mV for I
total, I
linear and I
out. I
linear can be defined as the instantaneously activated region and I
out as the slower activating component (see inset). Each point is the mean of 3–11 cells. IC50 values were 5.8, 1.2 and 16.0 
M, respectively. (b) XE991-sensitive current recordings at +20 mV determined with different concentrations of XE991. Currents were evoked by 200 ms depolarisations from -60 to +20 mV. Concentrations used were 0.1 (bi), 10 (bii) and 300
M (biii) XE991. (c) Bar chart illustrating XE991-sensitive current amplitudes of the I
total, I
linear and I
out components.