British Journal of Pharmacology

FIGURE 3

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

S G Sydserff, A R Borelli, A R Green and A J Cross

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Figure 3.

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The effect of increasing doses of NXY-059 on the volume of ischaemic damage in (a) the cortex and (b) the sub-cortex following permanent MCA occlusion in rats. (c) Shows the effect of the drug on the total volume of damage and (d) the per cent protection against damage (using the total volume data) versus the dose of NXY-059 administered. The number of animals in each group=8. *Shows a significant difference from vehicle treatment at P<0.05 (ANOVA with Newman-Keuls post-hoc analysis).

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