British Journal of Pharmacology

FIGURE 1

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Effect of NXY-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

S G Sydserff, A R Borelli, A R Green and A J Cross

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Figure 1.

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The neurological deficit (a) and infarct volume (b) of groups of rats (n=9 − 10) administered various infusion doses of NXY-059 (3, 10 and 30 mg kg-1 h for 21.75 h) starting 2.25 h post-occlusion, together with the respective control groups. *Shows a significant difference from vehicle treatment at P<0.05 (ANOVA with Newman-Keuls post-hoc analysis).

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