PARP inhibitors in ovarian cancer

Guest editor: Jonathan A Ledermann

Volume 113, Issue S1, (S1-S21) Published online 15 December 2015

In this supplement, the authors comprehensively review molecular and clinical evidence underlying the evolution of poly (ADP-ribose) polymerase (PARP) inhibitors in a journey spanning 50 years, which culminates in the recent licensing approval of the first oral PARP inhibitor, olaparib (Lynparzat™), for BRCA-mutated high-grade serous ovarian cancer. In addition, it discusses current UK procedures for BRCA testing of at-risk women and considers BRCA mutation genetic testing models for patients with ovarian cancer.

Diagnosing Cancer Earlier: Reviewing the evidence for improving cancer survival

Guest editor: Sara Hiom

Volume 112, Issue S1, (S1-S136) Published online 31 March 2015

Occupational Cancer in Britain

Guest editors: Lesley Rushton and Gareth Evans
with the British Occupational Cancer Burden Study Group
Foreword by Kurt Straif

Volume 107, Issue S1, (S1-S108) Published online 19 June 2012

This study aims to provide an objective estimate of the burden of cancer in Britain due to occupation. It presents extensive analyses for all carcinogens and occupational circumstances defined as relevant by IARC. The results should help the development of an evidence-based approach for occupational cancer control.

The Fraction of Cancer Attributable to Lifestyle and Environmental Factors in the UK in 2010

D Max Parkin et al
with a foreword by Richard Peto

Volume 105, Issue S2, (S1-S81) Published online 6 December 2011

The papers in this supplement estimate the percentage of cancers occurring in the UK in 2010 that were the result of exposure to common and for the most part modifiable lifestyle, dietary and environmental factors, providing a firm background for making individual lifestyle and public health policy decisions.

The National Cancer Survivorship Initiative:
New and Emerging Evidence on the Ongoing Needs of Cancer Survivors

Guest Editors: Mike Richards, Jessica Corner and Jane Maher

Volume 105, Issue S1, (S1-S94) Published online 3 November 2011

This supplement brings together new research in the field of cancer survivorship, to address gaps in data and evidence and to stimulate evidence based research on the needs of cancer survivors and the most effective models of services, care and support to address their needs.

Prevention and Treatment of Cancer-Associated Thrombosis

Edited by: A K Kakkar and R Coleman

Volume 102, Issue S1, (S1-S129) Published online 13 April 2010

Venous thromboembolism (VTE) is an increasingly recognised complication of surgical treatments for cancer and also for some cancer patients receiving chemotherapy. This supplement provides a broad-based review of the prevention and treatment of VTE, and the impact of anticoagulants on prognosis and survival.

Diagnosing Cancer Earlier: Evidence for a National Awareness and Early Diagnosis Initiative

Edited by: Mike Richards and Sara Hiom

Volume 101, Issue S2, (S1-S129) Published online 3 December 2009

Late diagnosis is generally accepted as a key factor in poor cancer survival rates. Researchers from many disciplines here set out the evidence and the enormous potential benefits of further identifying and tackling the root causes.

Breast cancer: Improved care through effective management of febrile neutropenia

Guest Editors: Alison Jones and Robert Leonard

Volume 101, Issue S1, (S1-S26) Published online 15 September 2009

The articles in this supplement consider the burdens imposed by febrile neutropenia, and the strategies available for preventing as well as providing optimum management for this common side effect of many chemotherapy regimens.

Trends and inequalities in survival for 20 cancers in England and Wales 1986-2001: population-based analyses and clinical commentaries

Volume 99, Issue S1, (S1-S120) Published online 23 September 2008

The unique pairing of epidemiology and expert clinical analysis in this supplement provides a complete picture of the state of cancer survival and cancer care in England and Wales, focussing on the 20 most common cancers diagnosed in England and Wales over a 14-year period from 1986 to 1999. The analyses are based on data collected by cancer registries on 2.2 million cancer patients. The authors have assessed both trends in survival rates over time and inequalities in survival associated with deprivation.