Keyword Index

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Results 71 - 80 of 306 shown below

  • GDNF

    O Gimm, A Gössling, D J Marsh, P L M Dahia, L M Mulligan, A von Deimling and C Eng

    Mutation and deletion analysis of GFRalpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours

    doi:10.1038/sj.bjc.6690367

  • GDNFRalpha

    O Gimm, A Gössling, D J Marsh, P L M Dahia, L M Mulligan, A von Deimling and C Eng

    Mutation and deletion analysis of GFRalpha-1, encoding the co-receptor for the GDNF/RET complex, in human brain tumours

    doi:10.1038/sj.bjc.6690367

  • gef gene

    H Boulaiz, J Prados, C Melguizo, Á M García, J A Marchal, J L Ramos, E Carrillo, C Vélez and A Aranega

    Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene

    doi:10.1038/sj.bjc.6601064

  • gefitinib

    S Okubo, J Kurebayashi, T Otsuki, Y Yamamoto, K Tanaka and H Sonoo

    Additive antitumour effect of the epidermal growth factor receptor tyrosine kinase inhibitor gefitinib (Iressa, ZD1839) and the antioestrogen fulvestrant (Faslodex, ICI 182,780) in breast cancer cells

    doi:10.1038/sj.bjc.6601504

  • G Blackledge and S Averbuch

    Gefitinib ('Iressa', ZD1839) and new epidermal growth factor receptor inhibitors

    doi:10.1038/sj.bjc.6601550

  • J E Nutt, H P Lazarowicz, J K Mellon and J Lunec

    Gefitinib ('Iressa', ZD1839) inhibits the growth response of bladder tumour cell lines to epidermal growth factor and induces TIMP2

    advance online publication, 2004-04-06 00:00:00.000;

    doi:10.1038/sj.bjc.6601768

  • B F El-Rayes and P M LoRusso

    Targeting the epidermal growth factor receptor

    advance online publication, 2004-07-06 00:00:00.000;

    doi:10.1038/sj.bjc.6601921

  • G Giannelli, A Azzariti, E Fransvea, L Porcelli, S Antonaci and A Paradiso

    Laminin-5 offsets the efficacy of gefitinib ('Iressa') in hepatocellular carcinoma cells

    advance online publication, 2004-11-16 00:00:00.000;

    doi:10.1038/sj.bjc.6602231

  • N Giocanti, C Hennequin, D Rouillard, R Defrance and V Favaudon

    Additive interaction of gefitinib ('Iressa', ZD1839) and ionising radiation in human tumour cells in vitro

    advance online publication, 2004-11-16 00:00:00.000;

    doi:10.1038/sj.bjc.6602242

  • F Barlési, C Tchouhadjian, C Doddoli, J-P Torre, P Astoul and J-P Kleisbauer

    CYFRA 21-1 level predicts survival in non-small-cell lung cancer patients receiving gefitinib as third-line therapy

    advance online publication, 2004-12-14 00:00:00.000;

    doi:10.1038/sj.bjc.6602296

  • Y Nobuhara, N Onoda, Y Yamashita, M Yamasaki, K Ogisawa, T Takashima, T Ishikawa and K Hirakawa

    Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines

    advance online publication, 2005-03-22 00:00:00.000;

    doi:10.1038/sj.bjc.6602461

  • Y Ueno, H Sakurai, M Matsuo, M K Choo, K Koizumi and I Saiki

    Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib

    advance online publication, 2005-04-19 00:00:00.000;

    doi:10.1038/sj.bjc.6602548

  • Y Kokubo, A Gemma, R Noro, M Seike, K Kataoka, K Matsuda, T Okano, Y Minegishi, A Yoshimura, M Shibuya and S Kudoh

    Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)

    doi:10.1038/sj.bjc.6602559

  • M L Veronese, W Sun, B Giantonio, J Berlin, J Shults, L Davis, D G Haller and P J O'Dwyer

    A phase II trial of gefitinib with 5-fluorouracil, leucovorin, and irinotecan in patients with colorectal cancer

    advance online publication, 2005-05-03 00:00:00.000;

    doi:10.1038/sj.bjc.6602569

  • S-T Lim, E-H Wong, K-L Chuah, S-S Leong, W-T Lim, M-H Tay, C-K Toh and E-H Tan

    Gefitinib is more effective in never-smokers with non-small-cell lung cancer: experience among Asian patients

    advance online publication, 2005-06-07 00:00:00.000;

    doi:10.1038/sj.bjc.6602652

  • M W Pedersen, N Pedersen, L H Ottesen and H S Poulsen

    Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII

    advance online publication, 2005-09-27 00:00:00.000;

    doi:10.1038/sj.bjc.6602793

  • F Cappuzzo, L Toschi, I Domenichini, S Bartolini, G L Ceresoli, E Rossi, V Ludovini, A Cancellieri, E Magrini, L Bemis, W A Franklin, L Crino, P A Bunn, F R Hirsch and M Varella-Garcia

    HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients

    advance online publication, 2005-11-15 00:00:00.000;

    doi:10.1038/sj.bjc.6602865

  • I Laux, A Jain, S Singh and D B Agus

    Epidermal growth factor receptor dimerization status determines skin toxicity to HER-kinase targeted therapies

    advance online publication, 2005-11-22 00:00:00.000;

    doi:10.1038/sj.bjc.6602875

  • A M Kirby, R P A'hern, C D'ambrosio, M Tanay, K N Syrigos, S J Rogers, C Box, S A Eccles, C M Nutting and K J Harrington

    Gefitinib (ZD1839, Iressa™) as palliative treatment in recurrent or metastatic head and neck cancer

    advance online publication, 2006-02-21 00:00:00.000;

    doi:10.1038/sj.bjc.6602999

  • R Suzuki, Y Hasegawa, K Baba, H Saka, H Saito, H Taniguchi, M Yamamoto, S Matsumoto, K Kato, T Oishi, K Imaizumi and K Shimokata

    A phase II study of single-agent gefitinib as first-line therapy in patients with stage IV non-small-cell lung cancer

    advance online publication, 2006-05-02 00:00:00.000;

    doi:10.1038/sj.bjc.6603159

  • H E Jones, J M W Gee, D Barrow, D Tonge, B Holloway and R I Nicholson

    Inhibition of insulin receptor isoform-A signalling restores sensitivity to gefitinib in previously de novo resistant colon cancer cells

    advance online publication, 2006-07-04 00:00:00.000;

    doi:10.1038/sj.bjc.6603237

  • A Bozec, S Lassalle, J Gugenheim, J-L Fischel, P Formento, P Hofman and G Milano

    Enhanced tumour antiangiogenic effects when combining gefitinib with the antivascular agent ZD6126

    advance online publication, 2006-08-29 00:00:00.000;

    doi:10.1038/sj.bjc.6603308

  • C M McClelland and W J Gullick

    Proteomic identification of secreted proteins as surrogate markers for signal transduction inhibitor activity

    advance online publication, 2007-01-09 00:00:00.000;

    doi:10.1038/sj.bjc.6603544

  • J E Nutt, P A Foster, J K Mellon and J Lunec

    hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours

    advance online publication, 2007-02-20 00:00:00.000;

    doi:10.1038/sj.bjc.6603620

  • H Uramoto and T Mitsudomi

    Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?

    advance online publication, 2007-02-27 00:00:00.000;

    doi:10.1038/sj.bjc.6603665

  • E Franceschi, G Cavallo, S Lonardi, E Magrini, A Tosoni, D Grosso, L Scopece, V Blatt, B Urbini, A Pession, G Tallini, L Crinò and A A Brandes

    Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)

    advance online publication, 2007-03-13 00:00:00.000;

    doi:10.1038/sj.bjc.6603669

  • M Satouchi, S Negoro, Y Funada, Y Urata, T Shimada, S Yoshimura, Y Kotani, T Sakuma, H Watanabe, S Adachi, Y Takada, Y Yatabe and T Mitsudomi

    Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib

    advance online publication, 2007-03-27 00:00:00.000;

    doi:10.1038/sj.bjc.6603710

  • A Bozec, P Formento, S Lassalle, C Lippens, P Hofman and G Milano

    Dual inhibition of EGFR and VEGFR pathways in combination with irradiation: antitumour supra-additive effects on human head and neck cancer xenografts

    advance online publication, 2007-06-26 00:00:00.000;

    doi:10.1038/sj.bjc.6603791

  • G Lorch, J L Gilmore, P F Koltz, R M Gonterman, R Laughner, D A Lewis, R L Konger, K S Nadella, R E Toribio, T J Rosol and J Foley

    Inhibition of epidermal growth factor receptor signalling reduces hypercalcaemia induced by human lung squamous-cell carcinoma in athymic mice

    advance online publication, 2007-05-29 00:00:00.000;

    doi:10.1038/sj.bjc.6603828

  • H Kimura, M Suminoe, K Kasahara, T Sone, T Araya, S Tamori, F Koizumi, K Nishio, K Miyamoto, M Fujimura and S Nakao

    Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA)

    doi:10.1038/sj.bjc.6603949

  • A G Pallis, A Voutsina, Ar Kalikaki, J Souglakos, E Briasoulis, S Murray, A Koutsopoulos, M Tripaki, E Stathopoulos, D Mavroudis and V Georgoulias

    'Classical' but not 'other' mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer

    advance online publication, 2007-11-13 00:00:00.000;

    doi:10.1038/sj.bjc.6604068

  • S Cascinu, R Berardi, S Salvagni, G D Beretta, V Catalano, F Pucci, A Sobrero, P Tagliaferri, R Labianca, M Scartozzi, F Crocicchio, E Mari and A Ardizzoni

    A combination of gefitinib and FOLFOX-4 as first-line treatment in advanced colorectal cancer patients. A GISCAD multicentre phase II study including a biological analysis of EGFR overexpression, amplification and NF-kB activation

    advance online publication, 2007-12-04 00:00:00.000;

    doi:10.1038/sj.bjc.6604121

  • J Stebbing, M Harrison, R Glynne-Jones, J Bridgewater and D Propper

    A phase II study to determine the ability of gefitinib to reverse fluoropyrimidine resistance in metastatic colorectal cancer (the INFORM study)

    advance online publication, 2008-02-05 00:00:00.000;

    doi:10.1038/sj.bjc.6604232

  • K Tamura, I Okamoto, T Kashii, S Negoro, T Hirashima, S Kudoh, Y Ichinose, N Ebi, K Shibata, T Nishimura, N Katakami, T Sawa, E Shimizu, J Fukuoka, T Satoh and M Fukuoka

    Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403)

    advance online publication, 2008-02-19 00:00:00.000;

    doi:10.1038/sj.bjc.6604249

  • C Lemos, I Kathmann, E Giovannetti, C Calhau, G Jansen and G J Peters

    Impact of cellular folate status and epidermal growth factor receptor expression on BCRP/ABCG2-mediated resistance to gefitinib and erlotinib

    advance online publication, 2009-03-10 00:00:00.000;

    doi:10.1038/sj.bjc.6604980

  • gefitinib ('Iressa')

    A Onn, M Tsuboi and N Thatcher

    Treatment of non-small-cell lung cancer: a perspective on the recent advances and the experience with gefitinib

    doi:10.1038/sj.bjc.6602062

  • P Camus, S Kudoh and M Ebina

    Interstitial lung disease associated with drug therapy

    doi:10.1038/sj.bjc.6602063

  • T Higenbottam, K Kuwano, B Nemery and Y Fujita

    Understanding the mechanisms of drug-associated interstitial lung disease

    doi:10.1038/sj.bjc.6602065

  • gefitinib ('Iressa', ZD1839)

    H Cortes-Funes and H Soto Parra

    Extensive experience of disease control with gefitinib and the role of prognostic markers

    doi:10.1038/sj.bjc.6601476

  • N van Zandwijk

    Tolerability of gefitinib in patients receiving treatment in everyday clinical practice

    doi:10.1038/sj.bjc.6601477

  • A Katz and P Zalewski

    Quality-of-life benefits and evidence of antitumour activity for patients with brain metastases treated with gefitinib

    doi:10.1038/sj.bjc.6601478

  • R Stahel, A Rossi, L Petruzelka, P Kosimidis, F de Braud, M M Bernardo, P-J Souquet, H Soto Parra and C Gridelli

    Lessons from the 'Iressa' Expanded Access Programme: gefitinib in special non-small-cell lung cancer patient populations

    doi:10.1038/sj.bjc.6601479

  • gelatin zymography

    E T Waas, R M L M Lomme, J DeGroot, Th Wobbes and T Hendriks

    Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer

    doi:10.1038/sj.bjc.6600366

  • gelatinase

    K Airola, T Karonen, M Vaalamo, K Lehti, J Lohi, A-L Kariniemi, J Keski-Oja and U K Saarialho-Kere

    Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas

    doi:10.1038/sj.bjc.6690417

  • J Varani, Y Hattori, M K Dame, T Schmidt, H S Murphy, K J Johnson and K J Wojno

    Matrix metalloproteinases (MMPs) in fresh human prostate tumour tissue and organ-cultured prostate tissue: Levels of collagenolytic and gelatinolytic MMPs are low, variable and different in fresh tissue versus organ-cultured tissue

    doi:10.1054/bjoc.2000.1712

  • gelatinase A

    A Talvensaari-Mattila, P Pääkkö and T Turpeenniemi-Hujanen

    Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma

    doi:10.1038/sj.bjc.6601238

  • gelatinase activity assay

    E T Waas, R M L M Lomme, J DeGroot, Th Wobbes and T Hendriks

    Tissue levels of active matrix metalloproteinase-2 and -9 in colorectal cancer

    doi:10.1038/sj.bjc.6600366