1. ¹Department of Clinical and Metabolic Genetics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
2. ²Women's College Research Institute, Women's College Hospital and the University of Toronto, Toronto, Ontario, Canada
3. ³Division of Respirology, Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada

Correspondence: Dr SA Narod, Women's College Research Institute, 7th Floor, 790 Bay Street, Toronto, Ontario M5G 1N8, Canada; E-mail: steven.narod@wchospital.ca

Received 18 May 2009; Revised 2 September 2009; Accepted 30 September 2009; Published online 3 November 2009.

Abstract

Both environmental and genetic factors have a role in the aetiology of gastric cancer. The nature of the genetic factors has not been well-studied and, outside of a few rare cancer syndromes, the genes involved have not been identified. Having a first-degree relative with gastric cancer is a consistent risk factor for gastric cancer, although the magnitude of the odds ratio (OR) associated with a positive family history varies with the ethnic group and with the geographic region. In published case–control studies, the odds ratio varies from approximately 2 to 10, depending on the country. Unlike other common adult cancers, the risk of gastric cancer in migrants is similar to that of the population of origin and does not approach that of the host population in the first generation post-migration. It is hoped that molecular studies, including genomewide association studies (GWAS), will illuminate the genetic factors underlying this important association.