TABLE 1

FROM:

Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro

M K Robinson, K M Hodge, E Horak, Å L Sundberg, M Russeva, C C Shaller, M von Mehren, I Shchaveleva, H H Simmons, J D Marks and G P Adams

Table 1. Expression levels of ErbB2 and ErbB3 on cell lines

Cell line	ErbB2	ErbB3
SK-OV-3	9.6 105	3.0 103
BT-474	7.6 105	5.1 104
MDA-361/DYT2	2.9 105	2.2 104
MDA-MB-468	<1 102	1.6 104
MCF10a	3.5 104	5.0 103
T-47D	5.2 104	ND
MDA-MB-231	2.8 104	ND
MVM2	3.5 105	NA

 NA=not applicable, cell line is of murine origin and not expected to express human ErbB3; ND=not tested.

 Expression levels were determined by quantitative flow cytometry on the basis of the assumption that each antibody bound to two receptors.